Statistics did not prove that the Huanan Seafood Wholesale Market was the early epicentre of the COVID-19 pandemic

Dietrich Stoyan, Sung Nok Chiu
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Abstract In a recent prominent study, Worobey et al. (2022. The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic. Science, 377(6609), 951–959) purported to demonstrate statistically that the Huanan Seafood Wholesale Market was the epicentre of the early COVID-19 epidemic. We show that this statistical conclusion is invalid on two grounds: (a) The assumption that a centroid of early case locations or another simply constructed point is the origin of an epidemic is unproved. (b) A Monte Carlo test used to conclude that no other location than the seafood market can be the origin is flawed. Hence, the question of the origin of the pandemic has not been answered by their statistical analysis.
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统计数据无法证明华南海鲜批发市场是 COVID-19 大流行的早期震中
摘要 在最近的一项重要研究中,Worobey 等人(2022.武汉华南海鲜批发市场是 COVID-19 大流行的早期震中。Science,377(6609),951-959)声称从统计学角度证明华南海鲜批发市场是 COVID-19 早期流行的中心。我们的研究表明,这一统计结论是无效的,理由有二:(a) 假设早期病例地点的中心点或其他简单构建的点是疫情的起源点是不成立的。(b) Monte Carlo 检验得出的除海鲜市场外没有其他地点可能是疫源地的结论是有缺陷的。因此,他们的统计分析没有回答疫情起源的问题。
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On partial likelihood Using proxy pattern-mixture models to explain bias in estimates of COVID-19 vaccine uptake from two large surveys Relaxing the exclusion restriction in shift-share instrumental variable estimation Grace periods in comparative effectiveness studies of sustained treatments Statistics did not prove that the Huanan Seafood Wholesale Market was the early epicentre of the COVID-19 pandemic
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