Medication adherence halves COPD patients' hospitalization risk - evidence from Swiss health insurance data.

IF 3.1 3区医学 Q1 PRIMARY HEALTH CARE NPJ Primary Care Respiratory Medicine Pub Date : 2024-03-07 DOI:10.1038/s41533-024-00361-2

Anja Y Bischof, Johannes Cordier, Justus Vogel, Alexander Geissler

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Abstract

Medication adherence is vital for patients suffering from Chronic Obstructive Pulmonary Disease (COPD) to mitigate long-term consequences. The impact of poor medication adherence on inferior outcomes like exacerbations leading to hospital admissions is yet to be studied using real-world data. Using Swiss claims data from 2015-2020, we group patients into five categories according to their medication possession ratio. By employing a logistic regression, we quantify each category's average treatment effect of the medication possession ratio on hospitalized exacerbations. 13,557 COPD patients are included in the analysis. Patients with high medication adherence (daily medication reserve of 80% to 100%) are 51% less likely to incur exacerbation following a hospital stay than patients with the lowest medication adherence (daily medication reserve of 0% to 20%). The study shows that medication adherence varies strongly among Swiss COPD patients. Furthermore, high medication adherence immensely decreases the risk of hospitalized exacerbations.

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坚持用药可将慢性阻塞性肺病患者的住院风险减半--来自瑞士医疗保险数据的证据。

坚持用药对于慢性阻塞性肺病（COPD）患者减轻长期后果至关重要。关于用药依从性差对导致入院的病情恶化等不良后果的影响，目前尚未使用真实世界的数据进行研究。我们利用瑞士 2015-2020 年的理赔数据，根据患者的药物持有率将其分为五类。通过采用逻辑回归，我们量化了每个类别的药物持有率对住院加重的平均治疗效果。13,557 名慢性阻塞性肺病患者参与了分析。与用药依从性最低的患者（每日药物储备量为 0% 至 20%）相比，用药依从性高的患者（每日药物储备量为 80% 至 100%）住院后病情加重的可能性降低了 51%。研究表明，瑞士慢性阻塞性肺病患者的用药依从性差异很大。此外，用药依从性高可大大降低住院加重的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Primary Care Respiratory Medicine PRIMARY HEALTH CARE-RESPIRATORY SYSTEM

CiteScore

5.50

自引率

6.50%

发文量

审稿时长

10 weeks

期刊介绍： npj Primary Care Respiratory Medicine is an open access, online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the primary care management of respiratory and respiratory-related allergic diseases. Papers published by the journal represent important advances of significance to specialists within the fields of primary care and respiratory medicine. We are particularly interested in receiving papers in relation to the following aspects of respiratory medicine, respiratory-related allergic diseases and tobacco control: epidemiology prevention clinical care service delivery and organisation of healthcare (including implementation science) global health.