{"title":"Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing","authors":"Sara Abdel Azim , Cleo Whiting , Adam J. Friedman","doi":"10.1016/j.niox.2024.03.001","DOIUrl":null,"url":null,"abstract":"<div><p>Nitric oxide (NO) is produced in most cells in the skin and is an important regulator of essential cutaneous functions, including responses to UV irradiation, microbial defense, wound healing, melanogenesis and epidermal permeability barrier homeostasis. Harnessing the physiological activities of NO for therapeutic use is difficult because the molecule is highly reactive and unstable. A variety of exogenous NO delivery platforms have been developed and evaluated; however, they have limited clinical applications in dermatology due to instability and poor cutaneous penetration. NO-releasing nanomaterials overcome these limitations, providing targeted tissue delivery, and sustained and controlled NO release. This review provides a comprehensive and up-to-date evaluation of the use of NO-releasing nanomaterials in dermatology for the treatment of skin and soft tissue infections and wound healing.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"146 ","pages":"Pages 10-18"},"PeriodicalIF":3.2000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nitric oxide : biology and chemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1089860324000302","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
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Abstract
Nitric oxide (NO) is produced in most cells in the skin and is an important regulator of essential cutaneous functions, including responses to UV irradiation, microbial defense, wound healing, melanogenesis and epidermal permeability barrier homeostasis. Harnessing the physiological activities of NO for therapeutic use is difficult because the molecule is highly reactive and unstable. A variety of exogenous NO delivery platforms have been developed and evaluated; however, they have limited clinical applications in dermatology due to instability and poor cutaneous penetration. NO-releasing nanomaterials overcome these limitations, providing targeted tissue delivery, and sustained and controlled NO release. This review provides a comprehensive and up-to-date evaluation of the use of NO-releasing nanomaterials in dermatology for the treatment of skin and soft tissue infections and wound healing.
一氧化氮（NO）在皮肤的大多数细胞中产生，是皮肤基本功能的重要调节因子，包括对紫外线照射的反应、微生物防御、伤口愈合、黑色素生成和表皮渗透屏障的稳态。利用氮氧化物的生理活性进行治疗非常困难，因为这种分子具有高活性和不稳定性。目前已开发并评估了多种外源性 NO 释放平台，但由于其不稳定性和较差的皮肤渗透性，这些平台在皮肤科的临床应用非常有限。纳米技术是一种可以克服这些局限性的 NO 递送平台，可提供靶向组织递送以及持续、可控的 NO 释放。本综述对释放 NO 的纳米材料在皮肤科治疗皮肤和软组织感染、寻常痤疮和伤口愈合方面的应用进行了全面的最新评估。
期刊介绍：
Nitric Oxide includes original research, methodology papers and reviews relating to nitric oxide and other gasotransmitters such as hydrogen sulfide and carbon monoxide. Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.
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