Afferent Renal Denervation Attenuates Sympathetic Overactivation From the Paraventricular Nucleus in Spontaneously Hypertensive Rats.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-14 DOI:10.1093/ajh/hpae027

Kun-Hui Li, Jie-Min Lin, Si-Qi Luo, Min-Yan Li, Yi-Yong Yang, Meng-Meng Li, Pan-Yan Xia, Jin-Zi Su

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Abstract

Background: The effectiveness of renal denervation (RDN) in reducing blood pressure and systemic sympathetic activity in hypertensive patients has been established. However, the underlying central mechanism remains unknown. This study aimed to investigate the role of RDN in regulating cardiovascular function via the central renin-angiotensin system (RAS) pathway.

Methods: Ten-week-old spontaneously hypertensive rats (SHR) were subjected to selective afferent renal denervation (ADN) using capsaicin solution. We hypothesized that ADN would effectively reduce blood pressure and rebalance the RAS component of the paraventricular nucleus (PVN) in SHR.

Results: The experimental results show that the ADN group exhibited significantly lower blood pressure, reduced systemic sympathetic activity, decreased chronic neuronal activation marker C-FOS expression in the PVN, and improved arterial baroreflex function, compared with the Sham group. Furthermore, ACE and AT1 protein expression was reduced while ACE2 and MAS protein expression was increased in the PVN of SHR after ADN.

Conclusions: These findings suggest that RDN may exert these beneficial effects through modulating the central RAS pathway.

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自发性高血压大鼠的肾脏传入神经剥夺可减轻来自室旁核的交感神经过度激活。

肾脏去神经支配（RDN）在降低高血压患者血压和全身交感神经活动方面的效果已经得到证实。然而，其潜在的中枢机制仍然未知。本研究旨在探讨肾脏去神经节在通过中枢肾素-血管紧张素系统（RAS）途径调节心血管功能方面的作用。我们使用辣椒素溶液对十周大的自发性高血压大鼠（SHR）进行了选择性传入肾脏去神经支配（ADN）。我们假设 ADN 将有效降低 SHR 的血压并重新平衡 PVN 的 RAS 成分。实验结果表明，与 Sham 组相比，ADN 组血压明显降低，全身交感神经活性降低，下丘脑室旁核（PVN）慢性神经元活化标志物 C-FOS 表达减少，动脉气压反射功能改善。此外，ADN后，SHR下丘脑室旁核的ACE和AT1蛋白表达减少，而ACE2和MAS蛋白表达增加。这些研究结果表明，RDN 可能是通过调节中枢 RAS 通路来发挥这些有益作用的。

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