Effectiveness of onabotulinumtoxin A for refractory overactive bladder with cough-associated detrusor overactivity

Q4 Medicine IJU Case Reports Pub Date : 2024-03-03 DOI:10.1002/iju5.12716

Chie Nakai, Kosei Miwa, Akane Yamaguchi, Yasumichi Takeuchi, Masami Yamaguchi, Yasuhide Kitagawa, Takuya Koie

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Abstract

Introduction

We report a case of refractory overactive bladder with cough-associated detrusor overactivity treated by onabotulinumtoxin A.

Case presentation

A 79-year-old woman who underwent mid-urethral sling surgery 8 years ago complained mainly of urinary incontinence following abdominal pressure. Various medicines to treat overactive bladder symptoms were ineffective. Cystometry revealed cough-associated detrusor overactivity. Onabotulinumtoxin A injections in her bladder improved subjective symptoms, and cough-associated detrusor overactivity disappeared on cystometry.

Conclusions

Onabotulinumtoxin A injection effectively resolved refractory overactive bladder with urgency urinary incontinence due to cough-associated detrusor overactivity.

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奥诺布林毒素 A 治疗难治性膀胱过度活动症合并咳嗽相关性逼尿肌过度活动症的效果

我们报告了一例采用奥博毒素A治疗的难治性膀胱过度活动症合并咳嗽相关性逼尿肌过度活动症病例。一位79岁的妇女在8年前接受了尿道中段吊带手术，主要主诉为腹压后尿失禁。治疗膀胱过度活动症状的各种药物均无效。膀胱造影显示她患有咳嗽引起的逼尿肌过度活动症。在她的膀胱中注射奥诺布林毒素A后，主观症状得到了改善，膀胱测量结果显示咳嗽相关性逼尿肌过度活动消失了。奥诺布林毒素A注射液有效解决了因咳嗽相关性逼尿肌过度活动导致的难治性膀胱过度活动症和尿急尿失禁。

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