IJU Case Reports最新文献

Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Interstitial Lung Disease, Induced by Enfortumab Vedotin Plus Pembrolizumab for Advanced Urothelial Carcinoma 抗黑色素瘤分化相关基因5抗体阳性间质性肺疾病，由Enfortumab Vedotin联合派姆单抗治疗晚期尿路上皮癌

Q4 Medicine

IJU Case Reports

Pub Date : 2026-02-05 DOI: 10.1002/iju5.70148

Akira Saito, Hiroki Ishihara, Hanae Kondo, Toshio Takagi, Yasunobu Hashimoto

Introduction

Anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease is a rare but fatal adverse event following immune checkpoint inhibitor treatment for cancers. However, such cases have not been previously reported in patients with urothelial carcinoma.

Case Presentation

A 79-year-old Japanese woman with advanced unresectable bladder cancer was treated with first-line enfortumab vedotin plus pembrolizumab. During the second treatment cycle, interstitial lung disease developed, and the patient immediately received steroid pulse therapy. As interstitial lung disease rapidly progressed after the initiation of steroid pulse therapy, immunosuppressive treatment with cyclophosphamide and tacrolimus was added. However, interstitial lung disease did not improve, and the patient died on day 54 after initiating treatment. Detailed antibody examination revealed positive anti-melanoma differentiation-associated gene 5 antibodies.

Conclusion

We report the first case of anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease induced by enfortumab vedotin plus pembrolizumab in a patient with advanced urothelial carcinoma.

抗黑色素瘤分化相关基因5抗体阳性间质性肺疾病是免疫检查点抑制剂治疗癌症后罕见但致命的不良事件。然而，此类病例在尿路上皮癌患者中尚未报道。一名79岁的日本晚期不可切除膀胱癌妇女接受一线维多单抗联合派姆单抗治疗。在第二个治疗周期，间质性肺病发展，患者立即接受类固醇脉冲治疗。由于间质性肺疾病在类固醇脉冲治疗开始后迅速进展，添加了环磷酰胺和他克莫司的免疫抑制治疗。然而，间质性肺病没有改善，患者在开始治疗后的第54天死亡。详细抗体检查显示抗黑色素瘤分化相关基因5抗体阳性。结论：我们报告了第一例抗黑色素瘤分化相关基因5抗体阳性的间质性肺疾病，该疾病是由安替妥单抗和派姆单抗联合治疗的晚期尿路上皮癌患者。

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引用次数: 0

Robot-Assisted Radical Prostatectomy in a Patient With a Rectal Fistula Following Hydrogel Spacer Placement 机器人辅助根治性前列腺切除术治疗水凝胶垫片置入后直肠瘘患者。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-02-02 DOI: 10.1002/iju5.70147

Erika Ikezoe, Yasukazu Nakanishi, Gaku Okumura, Shu Gozu, Tomonori Kanagawa, Naoki Imasato, Kohei Hirose, Madoka Kataoka, Shugo Yajima, Hitoshi Masuda

Introduction

The polyethylene glycol-based hydrogel spacer (SpaceOAR; Boston Scientific, Marlborough, MA, USA) reduces the rectal dose during prostate radiotherapy and rarely leads to rectal ulceration or fistula formation. We report a case in which robot-assisted radical prostatectomy (RARP) was successfully performed following this rare complication.

Case Presentation

A 62-year-old man developed hematochezia after SpaceOAR placement. Magnetic resonance imaging (MRI) and colonoscopy revealed a rectal ulcer with a fistula. The patient initially received bowel rest and antibiotics, followed by an ileostomy. After endoscopic confirmation of reepithelialization and MRI evidence of hydrogel resorption, the stoma was closed. At his request, the patient subsequently underwent RARP, which was safely performed with transrectal ultrasound guidance.

Conclusion

RARP after a hydrogel-related rectal fistula is technically feasible; however, it should ideally be performed at an experienced center.

介绍：聚乙二醇基水凝胶间隔剂（SpaceOAR; Boston Scientific, Marlborough， MA， USA）在前列腺放疗期间减少直肠剂量，很少导致直肠溃疡或瘘管形成。我们报告一个病例，其中机器人辅助根治性前列腺切除术（RARP）成功执行后，这种罕见的并发症。病例介绍：一名62岁男性在放置space ear后出现便血。磁共振成像（MRI）和结肠镜检查显示直肠溃疡并瘘。患者最初接受肠道休息和抗生素治疗，随后进行回肠造口术。经内镜确认再上皮化和MRI证实水凝胶吸收后，关闭造口。在他的要求下，患者随后接受了RARP，并在经直肠超声引导下安全进行。结论：水凝胶相关性直肠瘘术后RARP技术可行；然而，最好是在有经验的中心进行。

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引用次数: 0

Primary Mucinous Borderline Tumor of the Testis: A Case Report 睾丸原发性黏液性交界性肿瘤1例。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-30 DOI: 10.1002/iju5.70139

Takeshi Shirota, Hiromi Nakanishi, Tomoaki Hakariya, Naoki Nishimura, Shunsuke Sato, Masahiro Nakashima

Introduction

Testicular mucinous borderline tumor is a rare primary testicular neoplasm with a generally favorable prognosis. Herein, we report a case diagnosed after high orchiectomy, with a brief literature review.

Case Presentation

A 77-year-old man presented with discomfort in the left scrotum. Computed tomography revealed enlargement and calcification of the left testis and indicated a testicular tumor. High orchiectomy was performed, and pathological examination revealed a mucinous borderline tumor. Postoperative upper and lower gastrointestinal endoscopy showed no abnormal findings, leading to the diagnosis of primary testicular mucinous borderline tumor. Twelve months postoperatively, no evidence of postoperative recurrence or metastasis was observed.

Conclusion

We presented a rare case of testicular mucinous borderline tumor. Considering the existence of a case with metastasis, long-term imaging follow-up is advised.

简介：睾丸黏液交界性肿瘤是一种罕见的原发性睾丸肿瘤，一般预后良好。在此，我们报告一例诊断后高位睾丸切除术，并简要的文献复习。病例介绍：一名77岁男性，表现为左阴囊不适。电脑断层显示左侧睾丸肿大及钙化，提示睾丸肿瘤。高位睾丸切除术，病理检查显示粘液性交界性肿瘤。术后上、下消化道内镜未见异常，诊断为原发性睾丸黏液交界性肿瘤。术后12个月，未见术后复发或转移迹象。结论：我们报告了一例罕见的睾丸黏液交界性肿瘤。考虑到存在转移病例，建议长期影像学随访。

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引用次数: 0

Drastic Response to Olaparib in a Patient With Metastatic Castration-Resistant Prostate Cancer Harboring BRCA2 Alterations and Near-Threshold Tumor Mutational Burden 转移性去势抵抗性前列腺癌患者对奥拉帕尼的剧烈反应携带BRCA2改变和近阈值肿瘤突变负担。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-28 DOI: 10.1002/iju5.70144

Kotaro Yokota, Takeo Kosaka, Tatsuaki Daimon, Shinnosuke Fujiwara, Kohei Nakamura, Hiroshi Nishihara, Mototsugu Oya

Introduction

BRCA2 alterations and high tumor mutational burden (TMB-H) are responsible for prostate cancer; however, their co-occurrence is uncommon, and evidence for PARP inhibition in the castration-sensitive setting remains limited. We describe a case of metastatic castration-resistant prostate cancer (CRPC) harboring both biomarkers, showing a marked response to olaparib.

Case Presentation

A 74-year-old man presented with urinary retention. Initial prostate-specific antigen (PSA) level was 11 ng/mL. Follow-up MRI revealed bilateral PI-RADS 5 lesions with seminal-vesicle invasion. Biopsy confirmed adenocarcinoma (Gleason score 5 + 5 = 10). Staging revealed osseous and 30-mm right internal iliac nodal metastasis. Genomic profiling identified a pathogenic BRCA2 mutation and near-threshold TMB. Chemohormonal therapy was discontinued early owing to severe infection, and olaparib was initiated. Over 3 months, MRI showed further regression of the primary lesion and nodal disease, and PSA and SCC decreased.

Conclusion

In metastatic CRPC harboring a BRCA2 mutation and near-threshold TMB, olaparib produced clear radiological and serological responses.

简介：BRCA2改变和高肿瘤突变负荷（TMB-H）是前列腺癌的原因；然而，它们的共存并不常见，并且在去势敏感的情况下PARP抑制的证据仍然有限。我们描述了一例转移性去势抵抗性前列腺癌（CRPC），其中包含两种生物标志物，显示对奥拉帕尼的显着反应。病例介绍：一名74岁男性，因尿潴留而就诊。前列腺特异性抗原（PSA）初始水平为11 ng/mL。后续MRI显示双侧PI-RADS 5病变伴精囊浸润。活检证实腺癌（Gleason评分5 + 5 = 10）。分期显示骨和30毫米右髂内淋巴结转移。基因组分析鉴定出致病性BRCA2突变和近阈值TMB。由于严重感染，化疗激素治疗早期停止，并开始使用奥拉帕尼。3个月后，MRI显示原发病变和淋巴结病变进一步消退，PSA和SCC下降。结论：在携带BRCA2突变和接近阈值TMB的转移性CRPC中，奥拉帕尼产生了明确的放射学和血清学反应。

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引用次数: 0

Non-Functional Paraganglioma of the Urinary Bladder: A Rare Cause of Bladder Tumor 膀胱非功能性副神经节瘤：一种罕见的膀胱肿瘤病因。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-27 DOI: 10.1002/iju5.70145

Matt Wainstein, Vivek Aslot, Faith Dennie, Mark Wainstein, Thenappan Chandrasekar

Introduction

Paragangliomas of the urinary bladder (PUBs) are rare neuroendocrine tumors, representing less than 0.06% of all bladder neoplasms. While most are functional and associated with catecholamine excess, approximately 15% are non-functional, often presenting asymptomatically and discovered incidentally. Due to their rarity, standardized management guidelines are lacking.

Case Presentation

We report a 57-year-old female evaluated for ureterolithiasis who was incidentally found to have a 1.5 cm posterior bladder lesion. Biopsy confirmed paraganglioma. Functional studies, including plasma and urinary metanephrines, were negative, establishing a non-functional tumor. DOTATATE PET/CT and genetic testing excluded metastasis and hereditary syndromes. At planned transurethral resection, no residual lesion was identified, and pathology was benign. The patient remains asymptomatic on follow-up.

Conclusion

This case illustrates the diagnostic challenges of non-functional PUBs and emphasizes the importance of multidisciplinary evaluation and vigilant follow-up in the absence of standardized management strategies.

膀胱副神经节瘤是一种罕见的神经内分泌肿瘤，在膀胱肿瘤中所占比例不到0.06%。虽然大多数是功能性的，与儿茶酚胺过量有关，但大约15%是非功能性的，通常是无症状的，偶然发现的。由于其稀缺性，缺乏标准化的管理指南。病例介绍：我们报告一名57岁女性，因输尿管结石而被检查，偶然发现膀胱后部有1.5厘米的病变。活检证实副神经节瘤。功能研究，包括血浆和尿肾上腺素，均为阴性，确定为非功能性肿瘤。DOTATATE PET/CT和基因检测排除转移和遗传性综合征。经尿道切除后，未发现残留病变，病理为良性。随访时患者仍无症状。结论：该病例说明了非功能性酒吧的诊断挑战，并强调了在缺乏标准化管理策略的情况下多学科评估和警惕随访的重要性。

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引用次数: 0

Testicular Ischaemia Following Diverticulitis Complicated by Colovesical Fistula: A Case Report 憩室炎并发膀胱瘘致睾丸缺血1例。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-22 DOI: 10.1002/iju5.70143

Kyle R. Joseph, Parul Garg, Romanthi Madawala, Bushra Othman, Femi E. Ayeni, Ewan MacDermid

Introduction

Colovesical fistula is a recognized complication of diverticulitis, but progression to testicular ischaemia is, to our knowledge, an unreported phenomenon. While colovesical fistulas occur in diverticular disease, the spread of infection to the testes is rare.

Case Presentation

A 47-year-old male with recurrent diverticulitis presented with abdominal pain and was found to have a pelvic abscess. Despite conservative management, the patient developed pneumaturia, dysuria, and right testicular pain. Preoperative scrotal ultrasonography with color Doppler demonstrated globally reduced but present intratesticular arterial flow; a decision was made to prioritize definitive source control of the colovesical fistula with laparoscopic anterior resection and defunctioning ileostomy. Repeat Doppler on Day 7 demonstrated complete absence of arterial flow to the right testis, necessitating orchiectomy for inflammatory necrosis.

Conclusion

We report what is, to our knowledge, the first documented case. This case highlights the need for vigilance for genitourinary symptoms in diverticulitis. Prompt recognition is vital to prevent irreversible testicular loss.

简介：膀胱瘘是憩室炎的一种公认的并发症，但据我们所知，进展为睾丸缺血是一种未报道的现象。虽然膀胱瘘发生在憩室疾病，但感染扩散到睾丸是罕见的。病例介绍：一名47岁男性复发性憩室炎，腹痛并发现盆腔脓肿。尽管进行了保守治疗，患者还是出现了肺炎、排尿困难和右侧睾丸疼痛。术前阴囊超声彩色多普勒显示睾丸内动脉血流整体减少但仍存在；我们决定优先采用腹腔镜前切除术和去功能回肠造口术来控制膀胱瘘的源头。第7天重复多普勒检查显示右侧睾丸完全没有动脉血流，需要切除睾丸以治疗炎症性坏死。结论：据我们所知，我们报告的是首例记录在案的病例。本病例强调需要警惕憩室炎的泌尿生殖系统症状。及时识别对于防止不可逆转的睾丸丧失至关重要。

{"title":"Testicular Ischaemia Following Diverticulitis Complicated by Colovesical Fistula: A Case Report","authors":"Kyle R. Joseph, Parul Garg, Romanthi Madawala, Bushra Othman, Femi E. Ayeni, Ewan MacDermid","doi":"10.1002/iju5.70143","DOIUrl":"10.1002/iju5.70143","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Colovesical fistula is a recognized complication of diverticulitis, but progression to testicular ischaemia is, to our knowledge, an unreported phenomenon. While colovesical fistulas occur in diverticular disease, the spread of infection to the testes is rare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 47-year-old male with recurrent diverticulitis presented with abdominal pain and was found to have a pelvic abscess. Despite conservative management, the patient developed pneumaturia, dysuria, and right testicular pain. Preoperative scrotal ultrasonography with color Doppler demonstrated globally reduced but present intratesticular arterial flow; a decision was made to prioritize definitive source control of the colovesical fistula with laparoscopic anterior resection and defunctioning ileostomy. Repeat Doppler on Day 7 demonstrated complete absence of arterial flow to the right testis, necessitating orchiectomy for inflammatory necrosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We report what is, to our knowledge, the first documented case. This case highlights the need for vigilance for genitourinary symptoms in diverticulitis. Prompt recognition is vital to prevent irreversible testicular loss.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12826882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PTHrP-Producing Renal Cell Carcinoma Presenting as Rapidly Progressive Cognitive Impairment: A Case Report 产生pthrp的肾细胞癌表现为快速进展性认知障碍1例报告。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-20 DOI: 10.1002/iju5.70142

Fumiakira Yano, Norifumi Sawada, Norikazu Tanaka, Koshiro Hikawa, Keiichiro Hirose, Yuko Ohtake, Takahiko Mitsui

Introduction

Humoral hypercalcemia of malignancy (HCM) caused by parathyroid hormone–related peptide (PTHrP) is a common paraneoplastic syndrome, and renal cell carcinoma (RCC) is one of the main causes. However, initial presentation with rapidly progressive cognitive decline is rare.

Case Presentation

A 68-year-old woman was presented with a rapidly progressive cognitive impairment. Laboratory tests revealed severe hypercalcemia with elevated PTHrP and suppressed parathyroid hormone levels. Thoracoabdominal computed tomography revealed an 8-cm left renal mass, which was pathologically diagnosed as a sarcomatoid RCC. She underwent left radical nephrectomy, after which serum calcium normalized and cognitive function improved markedly (Hasegawa Dementia Scale-Revised score 7→28).

Conclusion

This case demonstrates that an unexplained cognitive decline may be the first sign of PTHrP-producing RCC. Checking serum calcium levels is essential, and surgical removal of the tumor can reverse both metabolic and neurological symptoms.

由甲状旁腺激素相关肽（PTHrP）引起的恶性肿瘤体液性高钙血症（HCM）是一种常见的副肿瘤综合征，肾细胞癌（RCC）是其主要病因之一。然而，以快速进行性认知能力下降为首发表现是罕见的。病例介绍：一名68岁的女性表现为快速进行性认知障碍。实验室检查显示严重的高钙血症，PTHrP升高和甲状旁腺激素水平抑制。胸腹计算机断层扫描显示一个8厘米的左肾肿块，病理诊断为肉瘤样肾细胞癌。患者行左肾根治性切除术，术后血钙恢复正常，认知功能明显改善（Hasegawa痴呆量表-修订评分7→28分）。结论：本病例表明，不明原因的认知能力下降可能是产生pthrp的RCC的第一个征兆。检查血钙水平是必要的，手术切除肿瘤可以逆转代谢和神经症状。

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引用次数: 0

Renal Granuloma Distinct From the Renal Pelvis Following Bacillus Calmette–Guérin Treatment for Bladder Cancer: A Case Report 卡介苗-谷氨酰胺治疗膀胱癌致肾盂外肾肉芽肿1例。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-14 DOI: 10.1002/iju5.70141

Ryuji Oka, Yusuke Goto, Kosuke Mikami, Hiroto Kato, Ken Wakai, Kyokushin Hou, Kazuhiro Araki, Takashi Fujino, Kazuto Yamazaki, Yukio Naya

Introduction

The incidence of renal complication following BCG treatment is rare. Few previous studies have reported a solitary renal granuloma distinct from the renal pelvis following BCG treatment.

Case Presentation

An 85-year-old male underwent transurethral resection of the bladder tumor. A 6-week induction of intravesical BCG instillation therapy was planned; however, the sixth instillation was canceled owing to fever. Regular follow-up revealed no recurrence. However, 4 years later, CT revealed a right renal mass. With a clinical diagnosis of renal cell carcinoma, robot-assisted partial nephrectomy was performed. The pathological diagnosis was epithelioid cell granuloma with caseating necrosis. Stress cystography revealed no vesicoureteral reflux.

Conclusion

A renal granuloma caused by BCG is one of the differential diagnoses for solitary renal mass following BCG treatment, even if the mass is not adjacent to the renal pelvis.

简介：卡介苗治疗后肾脏并发症的发生率很低。以前很少有研究报道卡介苗治疗后出现与肾盂不同的孤立性肾肉芽肿。病例介绍：一位85岁男性接受经尿道膀胱肿瘤切除术。计划进行为期6周的膀胱内卡介苗灌注诱导治疗；然而，第六次注射因发烧而取消。定期随访未见复发。然而，4年后，CT显示右肾肿块。临床诊断为肾细胞癌，进行机器人辅助部分肾切除术。病理诊断为上皮样细胞肉芽肿伴干酪样坏死。应激性膀胱造影未见膀胱输尿管反流。结论：卡介苗引起的肾肉芽肿是卡介苗治疗后孤立性肾肿块的鉴别诊断之一，即使肿块不邻近肾盂。

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引用次数: 0

Administration of Desloratadine for Postorgasmic Illness Syndrome in a Japanese Teenager 地氯雷他定治疗日本青少年性高潮后疾病综合征。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-14 DOI: 10.1002/iju5.70128

Kaoru Ito, Ko Kobayashi, Kohei Hashimoto, Wakako Yorozuya, Ko Okabe, Seisuke Nofuji, Yasuyuki Sakai, Yuki Kyoda, Toshiaki Tanaka, Noaya Masumori

Introduction

Postorgasmic illness syndrome is a rare condition occurring after ejaculation. This syndrome can significantly affect the quality of life of patients.

Case Presentation

A 17-year-old boy suffered from annoying fatigue, headache, photophobia and the sensation of a flu-like state. He did not know the trigger of these symptoms. He visited a psychiatry clinic where he was diagnosed with depression. Although he received administration of selective serotonin reuptake inhibitors, his symptoms continued. Then he noticed that his symptoms occurred after ejaculation by masturbation or wet dreams. He visited our outpatient clinic when he was 19 years old. We administered desloratadine. One month later the general malaise after ejaculation improved. Thereafter, all symptoms after ejaculation disappeared.

Conclusions

A Japanese teenager suffering from postorgasmic illness syndrome was successfully treated with desloratadine. We believe that our experience will contribute to elucidating and treating this condition in the future.

简介：性高潮后疾病综合征是一种发生在射精后的罕见疾病。该综合征可显著影响患者的生活质量。病例介绍：一名17岁的男孩患有恼人的疲劳，头痛，畏光和流感样状态的感觉。他不知道引起这些症状的原因。他去了一家精神病诊所，在那里他被诊断出患有抑郁症。虽然他接受了选择性血清素再摄取抑制剂的治疗，但他的症状仍在继续。然后他注意到他的症状发生在手淫射精或梦遗之后。他19岁的时候来过我们的门诊。我们使用地氯雷他定。一个月后，射精后的全身不适有所改善。此后，射精后的所有症状消失。结论：地氯雷他定成功治疗了一名日本青少年性高潮后疾病综合征。我们相信，我们的经验将有助于阐明和治疗这种情况在未来。

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引用次数: 0

Neoadjuvant Avelumab Plus Axitinib Enabling Curative Resection of Renal Cell Carcinoma With Direct Liver Invasion: A Case Report 新辅助阿维单抗联合阿西替尼治疗直接侵犯肝脏的肾细胞癌1例报告。

Q4 Medicine

IJU Case Reports

Pub Date : 2026-01-08 DOI: 10.1002/iju5.70124

Fumihiro Ito, Koki Kobayashi, Gaku Hayashi, Shunsuke Kamijo, Takashi Fujita

Introduction

Direct liver invasion by renal cell carcinoma (RCC) is rare and often precludes margin-negative resection. Herein, we report a case where neoadjuvant treatment with avelumab plus axitinib downstaged the disease, enabling complete surgical resection.

Case Presentation

A 67-year-old woman presented with gross hematuria. Computed tomography revealed a 70-mm right renal mass with direct liver invasion. Core biopsy confirmed clear-cell RCC and clinical stage cT4N0M0. She received ten cycles of avelumab (10 mg/kg, biweekly) plus axitinib (10 mg/day), resulting in tumor shrinkage to 35 mm. She underwent open radical nephrectomy with partial hepatectomy, achieving negative surgical margins. Histological examination revealed hepatic parenchymal invasion, with no viable tumor at the inked hepatic margin. Adjuvant therapy was not administered. The patient has remained disease-free for 24 months.

Conclusion

In select cases of organ-invasive non-metastatic RCC, short-term neoadjuvant therapy with avelumab plus axitinib may allow for complete resection and prolonged disease control.

导言：肾细胞癌（RCC）直接侵犯肝脏是罕见的，通常排除边缘阴性切除。在此，我们报告了一个病例，其中新辅助治疗与阿维单抗加阿西替尼降低了疾病，使完全手术切除。病例介绍：一名67岁女性，表现为肉眼血尿。计算机断层扫描显示一个70毫米的右肾肿块，并直接侵犯肝脏。核心活检证实透明细胞RCC，临床分期为cT4N0M0。她接受了10个周期的avelumab （10mg /kg，双周）加阿西替尼（10mg /天）治疗，导致肿瘤缩小至35mm。她接受了开放性根治性肾切除术和部分肝切除术，手术切缘为阴性。组织学检查显示肝实质浸润，在浸润的肝边缘未见活的肿瘤。未给予辅助治疗。病人已无病24个月。结论：在特定的器官侵袭性非转移性RCC病例中，短期新辅助治疗联合阿维单抗和阿西替尼可能允许完全切除和延长疾病控制。

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引用次数: 0