Application of Aleppo pine extract for skin burn treatment.

IF 3.1 4区 医学 Q2 BIOPHYSICS Journal of Applied Biomaterials & Functional Materials Pub Date : 2024-01-01 DOI:10.1177/22808000241236020
Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah
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Abstract

Objective: To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns.

Methods: Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation.

Results: In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns.

Conclusion: This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.

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应用阿勒颇松提取物治疗皮肤烧伤。
目的研究欧洲赤松(Pinus halepensis)提取物,确定其愈合和抗菌效果,并评估其对皮肤烧伤的治疗效果:方法:制备水提取物、乙醇提取物和基于阿勒颇松植物提取物的外用药。用 30 只雄性和雌性 Wistar 大鼠研究阿勒颇松树皮提取物的皮肤毒性。此外,还通过评估伤口的临床和宏观方面,评估了提取物对烧伤伤口的愈合潜力。在这项研究中,验证了半枝莲粗萃取物的抗菌活性及其伤口愈合能力:结果:在急性皮肤中毒的动物中,没有出现与治疗相关的中毒或死亡迹象。这些植物的提取物可转化为治疗感染伤口的植物药。结果表明,配制的软膏能成功治疗大鼠的二度烧伤,可能适合二度烧伤的短期治疗:这项研究成功地回答了我们的问题,即我们的提取物对治疗大鼠二度烧伤的疗效。为了证实这些结果,还需要进行进一步的研究,确定这些活性的分子并研究其作用机制。
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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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