The Dynamics of Locomotor Neuromuscular Fatigue during Ramp-Incremental Cycling to Intolerance.

Abstract

Introduction: Traditional neuromuscular fatigue assessments are not task-specific and are unable to characterize neuromuscular performance decline during dynamic whole-body exercise. This study used interleaved maximal isokinetic cycling efforts to characterize the dynamics of the decline in neuromuscular performance during ramp-incremental (RI) cycle ergometry exercise to intolerance.

Methods: Eleven young healthy participants (10 male/1 female) performed two RI cycle ergometry exercise tests to intolerance: 1) RI exercise with peak isokinetic power (Piso) at 80 rpm measured at baseline and immediately at intolerance from a maximal ~6 s effort, and 2) RI exercise where additional Piso measurements were interleaved every 90 s to characterize the decline in neuromuscular performance during the RI test. Muscle excitation was measured using EMG during all Piso assessments, and pulmonary gas exchange was measured throughout.

Results: Baseline Piso was 832 ± 140 W and RI exercise reduced Piso to 349 ± 96 W at intolerance ( P = 0.001), which was not different from flywheel power at intolerance (303 ± 96 W; P = 0.292). There was no reduction in Piso between baseline cycling and gas exchange threshold (GET; baseline Piso vs mean Piso below GET: 828 ± 146 vs 815 ± 149 W; P = 1.00). Piso fell progressively above GET until intolerance (Piso every 90 s above GET: 759 ± 139, 684 ± 141, 535 ± 144, 374 ± 117 W; each P < 0.05 vs baseline and mean Piso below GET). Peak muscle excitation (EMG) was also reduced only above GET (73% ± 14% of baseline, at intolerance; P < 0.05). However, the reduction in peak Piso preceded the reduction in peak muscle excitation.

Conclusions: The dynamics of the decline in neuromuscular performance (reduction in Piso and EMG) during RI exercise are consistent with known intensity-dependent metabolic and traditional pre-post neuromuscular fatigue responses to discrete bouts of constant-power exercise.