{"title":"Structural Study of the Candida auris Ribosome","authors":"A. A. Atamas, A. I. Guskov, A. V. Rogachev","doi":"10.3103/s0096392523700220","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p><i>Candida auris</i> is a pathogenic fungus that causes infections in people with weakened immune systems. It is resistant to antimicrobial drugs, which complicates treatment. <i>C. auris</i> poses a serious threat to public health since it has high resistance and contagiousness. The ribosome plays an important role in the survival and development of this infection, and the search for inhibitors of the <i>C. auris</i> ribosome is of great importance. The authors used cryoelectron microscopy and single particle analysis to obtain the three-dimensional structure of the <i>C. auris</i> ribosome. Herein is described the architecture of the ribosome subunits and their interactions, providing valuable information for the development of novel antifungals against <i>C. auris</i>.</p>","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Biological Sciences Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3103/s0096392523700220","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
Candida auris is a pathogenic fungus that causes infections in people with weakened immune systems. It is resistant to antimicrobial drugs, which complicates treatment. C. auris poses a serious threat to public health since it has high resistance and contagiousness. The ribosome plays an important role in the survival and development of this infection, and the search for inhibitors of the C. auris ribosome is of great importance. The authors used cryoelectron microscopy and single particle analysis to obtain the three-dimensional structure of the C. auris ribosome. Herein is described the architecture of the ribosome subunits and their interactions, providing valuable information for the development of novel antifungals against C. auris.
摘要 念珠菌是一种致病真菌，会导致免疫力低下的人受到感染。它对抗菌药物具有抗药性，从而使治疗变得复杂。念珠菌具有很强的抗药性和传染性，对公共卫生构成严重威胁。核糖体在这种感染的生存和发展过程中起着重要作用，因此寻找 C. auris 核糖体的抑制剂非常重要。作者利用冷冻电子显微镜和单颗粒分析法获得了阿氏杆菌核糖体的三维结构。文中描述了核糖体亚基的结构及其相互作用，为开发新型抗真菌药提供了宝贵信息。
期刊介绍：
Moscow University Biological Sciences Bulletin is forum for research in all important areas of modern biology. It publishes original work on qualitative, analytical and experimental aspects of research. The scope of articles to be considered includes plant biology, zoology, ecology, evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, gerontology, developmental biology, bioinformatics, bioengineering, virology, and microbiology.
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