{"title":"Identification of Low Expression of GSN as a Key Prognosis Gene in Patients with Gastric Carcinoma","authors":"M. Hao, X. Zhang, Z. Li, S. Li, C. Li","doi":"10.1134/s1022795424020042","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Gelsolin (GSN) is an important actin-binding protein. The current studyidentified the potential role of GSN in Gastric cancer (GC) tumorigenesis and prognosis using bioinformatic analysis. The TCGA, GTEx, and GEO databases were used to gain clinicopathological data on GC patients. Expression of GSN across cancers was evaluated. Kaplan–Meier analyses were conducted to evaluatethe prognostic value of GSN, while the association between GSN expression and clinical characteristics in gastric carcinoma was evaluated using the UALCAN database. The potential diagnostic value of GSN was assessed by the construction of ROC curves. The putative underlying cellular mechanisms were investigated by GO and KEGG pathway enrichment analyses. The GSN mRNA was validated by RT-qPCR. GSN mRNA and protein expression were lower in gastric carcinoma tissue than in noncancerous tissue. GO and KEGG enrichment analyses revealed that GSN plays a key regulatory role in actin binding and capping and thec-erbB/EGFR and PI3K/Akt signaling pathways. GSN has a high diagnostic significance, and low GSN expression is associated with shorter overall survival (OS) in gastric carcinoma. GSN expression was a risk factor for the progression-free interval in patients with gastric carcinoma. We observed that the OS rate of patients with higher GSN expression levels was longer, and GSN had significant predictive value for the clinical outcome of GC. GSN expression is involved in the tumorigenesis of gastric carcinoma progression and may regard as a putative diagnostic and prognostic biomarker for gastric carcinoma.</p>","PeriodicalId":21441,"journal":{"name":"Russian Journal of Genetics","volume":"68 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s1022795424020042","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Gelsolin (GSN) is an important actin-binding protein. The current studyidentified the potential role of GSN in Gastric cancer (GC) tumorigenesis and prognosis using bioinformatic analysis. The TCGA, GTEx, and GEO databases were used to gain clinicopathological data on GC patients. Expression of GSN across cancers was evaluated. Kaplan–Meier analyses were conducted to evaluatethe prognostic value of GSN, while the association between GSN expression and clinical characteristics in gastric carcinoma was evaluated using the UALCAN database. The potential diagnostic value of GSN was assessed by the construction of ROC curves. The putative underlying cellular mechanisms were investigated by GO and KEGG pathway enrichment analyses. The GSN mRNA was validated by RT-qPCR. GSN mRNA and protein expression were lower in gastric carcinoma tissue than in noncancerous tissue. GO and KEGG enrichment analyses revealed that GSN plays a key regulatory role in actin binding and capping and thec-erbB/EGFR and PI3K/Akt signaling pathways. GSN has a high diagnostic significance, and low GSN expression is associated with shorter overall survival (OS) in gastric carcinoma. GSN expression was a risk factor for the progression-free interval in patients with gastric carcinoma. We observed that the OS rate of patients with higher GSN expression levels was longer, and GSN had significant predictive value for the clinical outcome of GC. GSN expression is involved in the tumorigenesis of gastric carcinoma progression and may regard as a putative diagnostic and prognostic biomarker for gastric carcinoma.
期刊介绍：
Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.
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