{"title":"Impact of [11C]methionine PET with Bayesian penalized likelihood reconstruction on glioma grades based on new WHO 2021 classification","authors":"Kei Wagatsuma, Kensuke Ikemoto, Motoki Inaji, Yuto Kamitaka, Shoko Hara, Kaoru Tamura, Kenta Miwa, Kaede Tsuzura, Taisei Tsuruki, Noriaki Miyaji, Kenji Ishibashi, Kenji Ishii","doi":"10.1007/s12149-024-01911-x","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The uptake of [<sup>11</sup>C]methionine in positron emission tomography (PET) imaging overlapped in earlier images of tumors. Bayesian penalized likelihood (BPL) reconstruction increases the quantitative values of tumors compared with conventional ordered subset-expectation maximization (OSEM). The present study aimed to grade glioma malignancy based on the new WHO 2021 classification using [<sup>11</sup>C]methionine PET images reconstructed using BPL.</p><h3>Methods</h3><p>We categorized 32 gliomas in 28 patients as grades 2/3 (<i>n</i> = 15) and 4 (<i>n</i> = 17) based on the WHO 2021 classification. All [<sup>11</sup>C]methionine images were reconstructed using OSEM + time-of-flight (TOF) and BPL + TOF (<i>β = </i>200). Maximum standardized uptake value (SUV<sub>max</sub>) and tumor-to-normal tissue ratio (T/N<sub>max</sub>) were measured at each lesion.</p><h3>Results</h3><p>The mean SUV<sub>max</sub> was 4.65 and 4.93 in grade 2/3 and 6.38 and 7.11 in grade 4, and the mean T/N<sub>max</sub> was 7.08 and 7.22 in grade 2/3 and 9.30 and 10.19 in grade 4 for OSEM and BPL, respectively. The BPL significantly increased these values in grade 4 gliomas. The area under the receiver operator characteristic (ROC) curve (AUC) for SUV<sub>max</sub> was the highest (0.792) using BPL.</p><h3>Conclusions</h3><p>The BPL increased mean SUV<sub>max</sub> and mean T/N<sub>max</sub> in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUV<sub>max</sub> was also increased using [<sup>11</sup>C]methionine PET images reconstructed with BPL.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-024-01911-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
The uptake of [11C]methionine in positron emission tomography (PET) imaging overlapped in earlier images of tumors. Bayesian penalized likelihood (BPL) reconstruction increases the quantitative values of tumors compared with conventional ordered subset-expectation maximization (OSEM). The present study aimed to grade glioma malignancy based on the new WHO 2021 classification using [11C]methionine PET images reconstructed using BPL.
Methods
We categorized 32 gliomas in 28 patients as grades 2/3 (n = 15) and 4 (n = 17) based on the WHO 2021 classification. All [11C]methionine images were reconstructed using OSEM + time-of-flight (TOF) and BPL + TOF (β = 200). Maximum standardized uptake value (SUVmax) and tumor-to-normal tissue ratio (T/Nmax) were measured at each lesion.
Results
The mean SUVmax was 4.65 and 4.93 in grade 2/3 and 6.38 and 7.11 in grade 4, and the mean T/Nmax was 7.08 and 7.22 in grade 2/3 and 9.30 and 10.19 in grade 4 for OSEM and BPL, respectively. The BPL significantly increased these values in grade 4 gliomas. The area under the receiver operator characteristic (ROC) curve (AUC) for SUVmax was the highest (0.792) using BPL.
Conclusions
The BPL increased mean SUVmax and mean T/Nmax in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUVmax was also increased using [11C]methionine PET images reconstructed with BPL.
期刊介绍:
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.