Exploration of the Clinical Effect of Different Autotransfusion Methods on Patients With Femoral Shaft Fracture Surgery

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY Journal of Clinical Laboratory Analysis Pub Date : 2024-03-11 DOI:10.1002/jcla.25018

Yujia Wang, Huan Wang, Jiaming Xu, Jinhuo Wang, Laiwei You, Yu Bai, Jianrong Guo

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Abstract

Objective

To explore the clinical effect of predeposit, salvage, and hemodilution autotransfusion on patients with femoral shaft fracture (FSF) surgery.

Methods

Selected patients with FSF were randomly divided into three groups: intraoperative blood salvage autotransfusion, preoperative hemodilution autohemotransfusion, and predeposit autotransfusion. Five days after the operation, the body temperature, heart rate, blood platelet (PLT), and hemoglobin (Hb) of patients were determined. The concentrations of EPO and GM-CSF in the three groups were calculated by ELISA. The content of CD14+ monocytes was calculated by FCM assay. The growth time and condition of the patient's callus were determined at the 30th, 45th, and 60th day after operation. Cox regression analysis was used to analyze the correlation between EPO, GM-CSF, CD14+ mononuclear content, callus growth, and autotransfusion methods.

Results

There were no statistically significant differences in body temperature and heart rate between the three groups (p > 0.05). PLT and Hb in the Predeposit group were markedly increased compared with that in the Salvage and Hemodilution groups. The concentrations of EPO and GM-CSF in the Predeposit group were markedly increased compared with that in the Salvage and Hemodilution groups. The content of CD14+ monocytes in the Predeposit group was significantly higher than that in the Salvage and Hemodilution groups. Predeposit autotransfusion promotes callus growth more quickly.

Conclusion

Predeposit autotransfusion promoted the recovery of patients with FSF after the operation more quickly than salvage autotransfusion and hemodilution autotransfusion.

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探讨不同自体输血方法对股骨柄骨折手术患者的临床效果。

目的探讨股骨干骨折（FSF）手术患者术前、术中、术后三组自体输血的临床效果：将选定的股骨干骨折患者随机分为三组：术中血液抢救性自体输血组、术前血液稀释性自体输血组和预存款自体输血组。术后五天，测定患者的体温、心率、血小板（PLT）和血红蛋白（Hb）。用酶联免疫吸附法计算三组患者体内 EPO 和 GM-CSF 的浓度。通过 FCM 检测法计算 CD14+ 单核细胞的含量。在术后第 30 天、第 45 天和第 60 天测定患者胼胝体的生长时间和状况。采用 Cox 回归分析法分析 EPO、GM-CSF、CD14+ 单核细胞含量、胼胝体生长和自体输血方法之间的相关性：三组体温和心率差异无统计学意义（P > 0.05）。与抢救组和血液稀释组相比，预存组的 PLT 和 Hb 明显增加。与抢救组和血液稀释组相比，预置组的 EPO 和 GM-CSF 浓度明显升高。预处理组 CD14+ 单核细胞的含量明显高于抢救组和血液稀释组。结论：结论：与抢救性自体输血和血液稀释性自体输血相比，预置自体输血能更快地促进FSF患者术后恢复。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.