The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice.

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Laboratory Animal Research Pub Date : 2024-03-11 DOI:10.1186/s42826-023-00187-y

Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain

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Abstract

Background: Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, oxidative stress and brain acetylcholine shortage are the key pathogenic causes.

Results: The current study shows that these derivatives have the potential to improve memory in mice by inhibiting scopolamine-induced acetylcholinesterase activity, oxidative and nitrosative stress, and improving locomotor activity and muscle grip strength in the rota rod test. When compared to the illness control, the memory-enhancing potential of novel N-benzyl pyridine-2-one derivatives was highly significant (P < 0.0001).

Conclusions: The observed memory ameliorating effect of novel N-benzyl pyridine-2-one makes them as a a good choice for treatment of individuals with cognitive impairment.

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新型 N-苄基吡啶-2-酮衍生物对东莨菪碱诱发的小鼠认知障碍的记忆改善作用。

背景：阿尔茨海默病（AD）是老年人最常见的进行性痴呆，是一种认知能力下降的慢性神经系统疾病。虽然阿尔茨海默病的根本原因尚不清楚，但氧化应激和脑乙酰胆碱缺乏是主要的致病原因：目前的研究表明，这些衍生物可抑制东莨菪碱诱导的乙酰胆碱酯酶活性、氧化应激和亚硝酸应激，改善小鼠的运动活性和rota棒试验中的肌肉握力，从而改善小鼠的记忆力。与疾病对照组相比，新型 N-苄基吡啶-2-酮衍生物的记忆增强潜力非常显著（P 结论）：观察到的新型 N-苄基吡啶-2-酮改善记忆的效果使其成为治疗认知障碍患者的良好选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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