Examining the interplay between cardiovascular disease and cancer incidence: Data from NHANES III and continuous

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS American heart journal plus : cardiology research and practice Pub Date : 2024-03-11 DOI:10.1016/j.ahjo.2024.100380

Omar M. Makram , Harikrishnan Hyma Kunhiraman , Ryan A. Harris , Catherine C. Hedrick , Khurram Nasir , Neal L. Weintraub , Xiaoling Wang , Avirup Guha

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Abstract

Introduction

This study aimed to investigate the relationship between risk factors of cancer among individuals with existing cardiovascular disease (CVD).

Methods

The analysis included 438 and 2100 CVD patients aged 65+ from NHANES-III and Continuous datasets, respectively. Competing risk models with subdistribution hazards ratio (aHR) were used to identify risk factors.

Results

Females in NHANES-III had lower cancer risk (aHR 0.39, P = 0.001) compared to males. Poor physical activity was associated with increased cancer risk in both datasets (aHR 2.59 in NHANES-III, aHR 1.59 in Continuous). In NHANES-Continuous, age (aHR 1.07, P < 0.001) and current smoking (aHR 2.55, P = 0.001) also showed a significant association with developing cancer. No other factors investigated showed significant associations.

Discussion

This study highlights the interplay between traditional risk factors and the elevated risk of cancer in CVD patients. Further research with larger samples and wider age ranges is needed to solidify these findings and inform intervention strategies.

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研究心血管疾病与癌症发病率之间的相互作用：来自 NHANES III 的数据和连续

导言本研究旨在调查患有心血管疾病（CVD）的人群中癌症风险因素之间的关系。方法分析对象包括分别来自 NHANES-III 和连续数据集的 438 名和 2100 名 65 岁以上的心血管疾病患者。结果与男性相比，NHANES-III 中的女性患癌风险较低（aHR 0.39，P = 0.001）。在这两个数据集中，体力活动不足与癌症风险增加有关（NHANES-III 中的 aHR 为 2.59，Continuous 中的 aHR 为 1.59）。在 NHANES-Continuous数据集中，年龄（aHR 1.07，P = 0.001）和目前吸烟（aHR 2.55，P = 0.001）也与罹患癌症有显著关联。本研究强调了传统风险因素与心血管疾病患者癌症风险升高之间的相互作用。要巩固这些发现并为干预策略提供依据，还需要对更大样本和更广年龄范围的人群进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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