American heart journal plus : cardiology research and practice最新文献

{"title":"Lived experience of people with hypertension in Ethiopia: A phenomenological study, 2025","authors":"Ousman Adal ,&nbsp;Mekides Misganaw ,&nbsp;Asnake Gashaw Belayneh ,&nbsp;Destaw Endeshaw ,&nbsp;Abebu Tegenaw Delie ,&nbsp;Yeshimebet Tamir Tsehay ,&nbsp;Tadele Fentabel Anagaw ,&nbsp;Eyob Ketema Bogale","doi":"10.1016/j.ahjo.2026.100729","DOIUrl":"10.1016/j.ahjo.2026.100729","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension poses a substantial and growing public health challenge in Ethiopia. Despite its increasing prevalence, significant knowledge gaps remain regarding how patients experience and manage the condition within their social, cultural, and economic contexts. This study aimed to explore the lived experiences of patients with hypertension in Ethiopia using a qualitative approach, contributing to improved understanding and supporting sustainable, equitable, and patient-centered care.</div></div><div><h3>Methods</h3><div>Data were collected from adults living with hypertension who were receiving treatment in tertiary hospitals in northwest Amhara, Ethiopia, in July 2025. Participants were selected using purposive and heterogeneous sampling to include both males and females across all age groups above 18 years. Data were collected in the local language (Amharic), translated into English, and imported into ATLAS.ti v7 for coding and analysis. A thematic analysis was conducted, and rigor was ensured by considering credibility, dependability, confirmability, and transferability.</div></div><div><h3>Results</h3><div>Eight themes emerged from the analysis: (1) emotional and cognitive responses to diagnosis; (2) health provider interaction and communication; (3) adaptation and self-management; (4) treatment challenges and complications; (5) social and family support; (6) impact on daily life; (7) perception and control of hypertension; and (8) healthcare system and access barriers. Participants highlighted the importance of tailored patient education, effective provider communication, and community engagement for improving adherence and health outcomes. While most participants accepted their condition calmly, prior knowledge and interactions with healthcare providers shaped understanding and coping strategies. Adaptation included lifestyle modification, dietary adherence, and treatment compliance, with some challenges such as transportation issues, medication shortages, and long waiting times noted.</div></div><div><h3>Conclusion</h3><div>Understanding patients lived experiences provides insights for designing culturally appropriate interventions, improving adherence, and enhancing overall management of hypertension in Ethiopia.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100729"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of pericardial incision on circulation and body oxygenation in pediatric patients with congenital heart disease","authors":"Takashi Sakamoto ,&nbsp;Naoki Matsumoto ,&nbsp;Satoko Yamazaki ,&nbsp;Ryota Mitsumori ,&nbsp;Takashi Suto ,&nbsp;Shigeru Saito","doi":"10.1016/j.ahjo.2026.100738","DOIUrl":"10.1016/j.ahjo.2026.100738","url":null,"abstract":"<div><h3>Study objective</h3><div>To evaluate the influence of pericardial incision (PI) on circulation and body oxygenation and identify factors influencing them in pediatric patients undergoing surgery for congenital heart disease (CHD).</div></div><div><h3>Design</h3><div>Prospective observational study.</div></div><div><h3>Setting</h3><div>Gunma Children's Medical Center from August 4, 2022 to May 30, 2025.</div></div><div><h3>Participants</h3><div>We evaluated 63 patients aged 0–18 years with CHD undergoing elective cardiovascular surgery.</div></div><div><h3>Main outcome measures</h3><div>Blood pressure (BP), central venous pressure (CVP), and tissue oxygenation index (TOI), representing systemic oxygenation, were measured before and after PI during surgery and compared between the pre- and post-incision periods. Univariate (logistic) regression analysis was performed with the age and type of disease set as explanatory variables.</div></div><div><h3>Results</h3><div>Systolic (sBP), diastolic (dBP), and mean blood pressure (mBP) significantly decreased after PI. CVP significantly increased from 4.93 (1.96) to 6.08 (2.47), <em>P</em> = 0.00005, CI = −1.6733 to −0.5889, ES = 0.53 (medium). TOI significantly decreased from 71.22 (7.25) to 70.41 (7.79), <em>P</em> = 0.00631, CI = 0.403–1.56, ES = 0.37 (small to medium). Age was the only significant explanatory variable to decrease the TOI value (coefficient (coef) = 0.0004, <em>P</em> = 0.0301, CI = 0.000113 to 0.0.000797).</div></div><div><h3>Conclusion</h3><div>PI increases venous congestion and reduces arterial pressure, leading to a decline in systemic oxygenation in patients with CHD. Therefore, age exhibits the most detrimental effect on this pathological condition.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100738"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel cholesterol lowering drugs: Can phase 2/3 clinical trial safety assessments predict cardiovascular event outcome trial efficacy?","authors":"Charles Shear ,&nbsp;Michael H. Davidson ,&nbsp;Marc Ditmarsch ,&nbsp;John J.P. Kastelein ,&nbsp;Michael Szarek","doi":"10.1016/j.ahjo.2026.100728","DOIUrl":"10.1016/j.ahjo.2026.100728","url":null,"abstract":"<div><h3>Setting</h3><div>Prior to a cardiovascular outcomes trial (CVOT), novel cholesterol-lowering therapies undergo phase 2/3 studies for their lipid and atherosclerotic effects and safety (non-CVOTs). Since the occurrence of major adverse cardiovascular events (MACE) is part of the safety assessment, nominal reductions or increases may be observed prior to definitive testing of the effect in a CVOT.</div></div><div><h3>Study objective</h3><div>To investigate if the observed MACE treatment effect in non-CVOT lipid-lowering registration studies holds value in predicting the outcome in a CVOT trial, typically reported later than the initial lipid-lowering studies.</div></div><div><h3>Design/participants/interventions</h3><div>We reviewed recent development programs for cholesterol-lowering drugs that had completed non-CVOT and CVOT studies. MACE data were compared for phase 2/3 non-CVOT versus pivotal CVOT results.</div></div><div><h3>Main outcome measures</h3><div>Our primary outcome was a qualitative comparison for directionally concordant consistency in MACE risk ratio treatment effects (harm, neutrality, or benefit). Correlation analysis was also performed.</div></div><div><h3>Results</h3><div>Seven drugs were reviewed in 3 cholesterol-lowering classes: CETP inhibitors, bempedoic acid, and PCSK9 inhibitors. Concordance in non-CVOT vs CVOT results was seen in 6 of 7 drugs. One drug (dalcetrapib) had a trend for benefit observed, albeit with very small numbers, in early development, but showed a neutral CVOT. There was a moderate correlation between the risk reductions or increases from the non-CVOTs and CVOTs: <em>r</em> = 0.69, <em>p</em> = 0.0893.</div></div><div><h3>Conclusion</h3><div>Within the limitations of the drugs studied and the variability in MACE definitions, there is value in the results of non-CVOTs to predict the CVOT outcome.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100728"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial adipose tissue in coronary microvascular disease","authors":"Veronika Gašpárková ,&nbsp;Bao Thai Tran ,&nbsp;Petr Ošťádal ,&nbsp;Lukáš Lambert ,&nbsp;Petr Hájek ,&nbsp;Petr Kala","doi":"10.1016/j.ahjo.2026.100734","DOIUrl":"10.1016/j.ahjo.2026.100734","url":null,"abstract":"<div><div>Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and visceral pericardium, characterized by direct microvascular, paracrine, and vasocrine continuity with the heart. Under physiological conditions, EAT exhibits beige- and brown-fat-like features that support myocardial energy homeostasis, thermoregulation, and local cardioprotection. In obesity, diabetes, and aging, EAT undergoes pathological remodeling toward a pro-inflammatory and profibrotic phenotype. Accumulating evidence implicates excess and dysfunctional EAT in the pathophysiology of multiple cardiovascular diseases, including coronary artery disease, coronary microvascular dysfunction (CMD), vasospastic angina, atrial fibrillation, and heart failure. Through inflammatory signaling, immune activation, extracellular matrix remodeling, autonomic dysregulation, and mechanical pericardial restraint, EAT contributes to myocardial fibrosis, impaired diastolic function, CMD, and reduced exercise capacity.</div><div>This review focuses on the biological characteristics of EAT, current imaging approaches for its detection and quantification using echocardiography, cardiac computed tomography, and cardiac magnetic resonance imaging, and the relationship between EAT, CMD, and other cardiovascular pathologies. We also summarize therapeutic strategies targeting EAT, including pharmacological interventions with established cardiometabolic benefit, such as glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, intensive lipid-lowering therapies, and lifestyle interventions. Finally, we highlight ongoing clinical studies investigating EAT as an imaging biomarker and a potential therapeutic target in cardiometabolic cardiovascular disease.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100734"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into SGLT2 inhibitor efficacy in heart failure: A meta-analysis employing win ratio, hazard ratio, and risk ratio","authors":"Amir Nasrollahizadeh ,&nbsp;Sepide Javankiani ,&nbsp;Soheil Rahmati ,&nbsp;Ali Nasrollahizadeh ,&nbsp;Diaa Hakim ,&nbsp;Daniel Modin ,&nbsp;Niklas Dyrby Johansen ,&nbsp;Tor Biering-Sørensen ,&nbsp;Kaveh Hosseini","doi":"10.1016/j.ahjo.2026.100718","DOIUrl":"10.1016/j.ahjo.2026.100718","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100718"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pacemaker with automatic activation of a magnetic resonance imaging mode: A single-center experience","authors":"Bridget McIlraith ,&nbsp;Justin A. Mariani ,&nbsp;Ross Downey ,&nbsp;Geoffrey Clare ,&nbsp;Matthew Daly ,&nbsp;Houda El Banna ,&nbsp;Ian Crozier","doi":"10.1016/j.ahjo.2026.100732","DOIUrl":"10.1016/j.ahjo.2026.100732","url":null,"abstract":"<div><h3>Introduction</h3><div>In patients with permanent pacemakers, magnetic resonance imaging (MRI) traditionally requires resource-intensive manual device reprogramming before and after the scan putting demands on clinical resources.</div></div><div><h3>Methods</h3><div>In this single-center case series, we report five MRI procedures in three patients with a pacemaker using an always-on MRI workflow facilitating feature (MRI Guard 24/7) that automatically detects MRI conditions and adjusts the pacing mode without the need for pre- or post-scan checks.</div></div><div><h3>Results</h3><div>All scans were completed successfully, with automatic switching into MRI mode and reverting to the permanent setting. No device reconfigurations were required pre- or post-scan.</div></div><div><h3>Discussion</h3><div>We discuss the potential of this feature to streamline MRI workflows, reduce staffing demands and improve access to timely imaging for patients with cardiac implantable electronic devices.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100732"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting complications in emergency department patients with acute coronary syndrome – Existing risk scores versus a new logistic regression model","authors":"T. Nilsson ,&nbsp;M. Strömfors ,&nbsp;A. Trägårdh ,&nbsp;A. Mokhtari ,&nbsp;A.M. Khoshnood ,&nbsp;U. Ekelund","doi":"10.1016/j.ahjo.2026.100736","DOIUrl":"10.1016/j.ahjo.2026.100736","url":null,"abstract":"<div><h3>Background</h3><div>Patients with acute coronary syndrome (ACS) are often admitted to monitored wards due to the risk of complications. Several risk prediction scores exist, but their use in the emergency department (ED) is limited. We aimed to compare the ability of existing risk scores with a new logistic regression model in predicting complications in ACS patients.</div></div><div><h3>Methods</h3><div>This was a secondary analysis of data from the ESC TROP trial (<span><span>NCT03421873</span><svg><path></path></svg></span>), including ACS patients from five EDs in Region Skåne, Sweden (2017–2018). Complications were identified via diagnosis and/or intervention codes and manual chart review. GRACE, GRACE FFE, TIMI, HEART, ACTION ICU, and CHA₂DS₂-VASc scores were calculated. A new logistic regression model was developed, and its predictive performance was assessed using the area under the ROC curve (AUROC) and a net reclassification improvement analysis (NRI).</div></div><div><h3>Results</h3><div>Among 2223 ACS patients, 164 (7.4%) experienced complications. Independent predictors for complications included age, STEMI, troponin and lactate at arrival, shock index, Killip class, and new ECG changes. The logistic regression model's AUROC 0.84 (95% CI 0.80–0.88) outperformed all known risk scores: GRACE FFE 0.79 (0.75–0.84), ACTION ICU 0.77 (0.72–0.82), GRACE 0.76 (0.70–0.81), TIMI 0.74 (0.68–0.79), HEART 0.69 (0.64–0.74), and CHA₂DS₂-VASc 0.64 (0.59–0.69). Logistic regression improved reclassification of non-events, with a positive non-event NRI compared with all other scores.</div></div><div><h3>Conclusions</h3><div>Serious complications occurred in 7% of ACS patients. A logistic regression model based on simple ED variables showed excellent predictive performance, surpassing existing risk scores. Improved risk stratification may optimize resource allocation while maintaining patient safety.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100736"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: data accuracy","authors":"Magdalini Manti ,&nbsp;Panagiotis-Anastasios Tsioufis","doi":"10.1016/j.ahjo.2026.100727","DOIUrl":"10.1016/j.ahjo.2026.100727","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100727"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity paradox in patients with non‐ST‐elevation myocardial infarction undergoing percutaneous coronary intervention: A nationwide retrospective observational study","authors":"Sean Moore ,&nbsp;Aditya Thakkar ,&nbsp;Shahnawaz Notta ,&nbsp;Jacob Snipp ,&nbsp;Colin McGuire ,&nbsp;Venkata Vedantam ,&nbsp;Manar H. Jbara","doi":"10.1016/j.ahjo.2026.100733","DOIUrl":"10.1016/j.ahjo.2026.100733","url":null,"abstract":"<div><h3>Introduction</h3><div>The prevalence of obesity in the United States is high, with over 35% of the population classified as obese. Obesity, along with the lifestyle factors contributing to it, is considered a major risk factor for heart disease. However, research studies have reported controversial findings regarding its impact on morbidity and mortality.</div></div><div><h3>Methods</h3><div>Data was obtained from the Nationwide Inpatient Sample database from January 2016 to December 2020. The study included adult patients with a principal discharge diagnosis of NSTEMI who underwent PCI during hospitalization. They were divided into obese (BMI &gt; 30) and not obese (BMI &lt; 30). The primary outcome was inpatient mortality. Secondary outcomes were cardiogenic shock, cardiac arrest, arrhythmias, and acute renal failure, as well as the need for transfusions, pressors, ventilators, and ECMO.</div></div><div><h3>Results</h3><div>We analyzed 448,424 hospitalizations for NSTEMI, of which 172,665 patients underwent PCI. Among these, 39,548 (22.9%) were obese (BMI &gt;30). Obesity was associated with lower in-hospital mortality compared to non-obese patients (1.2% vs. 1.8%; adjusted odds ratio [aOR]: 0.82; 95% CI: 0.74–0.90; <em>p</em> &lt; 0.001), after adjustment for age, sex, race, and Charlson Comorbidity Index. Obese patients also had lower rates of cardiogenic shock (2.7% vs. 3.3%; aOR: 0.84; 95% CI: 0.78–0.90; <em>p</em> &lt; 0.001), cardiac arrest (1.3% vs. 1.6%; aOR: 0.86; 95% CI: 0.78–0.95; <em>p</em> &lt; 0.005), and ventricular arrhythmias (5.2% vs. 5.7%; aOR: 0.93; 95% CI: 0.88–0.98; p &lt; 0.005). They also required fewer blood transfusions (1.9% vs. 2.3%; aOR: 0.90; 95% CI: 0.83–0.98; <em>p</em> &lt; 0.05) and mechanical ventilation (2.9% vs. 3.2%; aOR: 0.91; 95% CI: 0.85–0.98; p &lt; 0.05). No significant differences were observed in dialysis, vasopressor use, or ECMO. However, obese patients had higher rates of acute kidney injury (15.0% vs. 13.5%; aOR: 1.25; 95% CI: 1.21–1.29; <em>p</em> &lt; 0.001) and acute respiratory failure (9.1% vs. 8.2%; aOR: 1.17; 95% CI: 1.13–1.23; p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The “obesity paradox” suggests that despite obesity's role in cardiovascular disease risk, individuals with obesity may have a survival advantage during acute cardiovascular events and certain surgeries. Our study aligns with these findings, underscoring the need for further research to comprehend the underlying pathophysiological mechanisms.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100733"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health and hospitalization risk in heart failure: A Retrospective analysis","authors":"Alisha A. Crump ,&nbsp;Milan Bimali ,&nbsp;Sanchia McCall ,&nbsp;Pearman Parker ,&nbsp;Taren Massey-Swindle ,&nbsp;Kevin Wayne Sexton ,&nbsp;Emel Seker ,&nbsp;Maryam Y. Garza ,&nbsp;Tremaine B. Williams","doi":"10.1016/j.ahjo.2026.100731","DOIUrl":"10.1016/j.ahjo.2026.100731","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure affects over 6.5 million Americans and accounts for substantial healthcare utilization, with social determinants of health (SDOH) increasingly recognized as critical factors influencing patient outcomes. The present study aims to examine the relationships among specific SDOH (food insecurity risk, financial resource strain, and medical transportation needs) with subsequent hospitalization risk among patients with heart failure.</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study analyzed electronic health record data from the Arkansas Clinical Data Repository for 2494 patients with heart failure hospitalized between January 2014 and December 2023 at the University of Arkansas for Medical Sciences. Quantile regression on the median was used to analyze the data.</div></div><div><h3>Results</h3><div>Study population descriptive results demonstrated moderate hospitalization risk (average score 40.3). The population was predominantly older adults (mean age ∼ 65), female (55.8%), non-Hispanic (98.3%) and White (54.3%). In fully adjusted models, all three social determinants remained significant predictors of increased subsequent hospitalization risk: food insecurity was associated with a 9.37-point increase (95% CI: 4.83–13.90, <em>p</em> &lt; 0.01), high financial resource strain with a 13.13-point increase (95% CI: 8.50–17.76, p &lt; 0.01), and medical transportation needs with a 13.23-point increase (95% CI: 7.55–18.89, p &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Food insecurity risk, financial resource strain, and medical transportation needs are associated with increased future hospitalization risk among patients with heart failure. These findings support the integration of social determinant screening into clinical risk stratification and the development of targeted interventions addressing these modifiable social factors to potentially reduce healthcare utilization and improve outcomes for vulnerable populations with heart failure.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"63 ","pages":"Article 100731"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}