Disentangling shared and private latent factors in multimodal Variational Autoencoders

Kaspar Märtens, Christopher Yau
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Abstract

Generative models for multimodal data permit the identification of latent factors that may be associated with important determinants of observed data heterogeneity. Common or shared factors could be important for explaining variation across modalities whereas other factors may be private and important only for the explanation of a single modality. Multimodal Variational Autoencoders, such as MVAE and MMVAE, are a natural choice for inferring those underlying latent factors and separating shared variation from private. In this work, we investigate their capability to reliably perform this disentanglement. In particular, we highlight a challenging problem setting where modality-specific variation dominates the shared signal. Taking a cross-modal prediction perspective, we demonstrate limitations of existing models, and propose a modification how to make them more robust to modality-specific variation. Our findings are supported by experiments on synthetic as well as various real-world multi-omics data sets.
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在多模态变异自动编码器中分辨共享和私有潜在因素
多模态数据的生成模型允许识别可能与观察到的数据异质性的重要决定因素相关的潜在因素。共同的或共享的因素可能对解释不同模态的变化很重要,而其他因素可能是私有的,只对解释单一模态很重要。多模态变异自动编码器(如 MVAE 和 MMVAE)是推断潜在因素和区分共享变异与私人变异的自然选择。在这项工作中,我们研究了它们可靠地执行这种分离的能力。特别是,我们强调了一个具有挑战性的问题设置,即特定模态变异在共享信号中占主导地位。从跨模态预测的角度出发,我们展示了现有模型的局限性,并提出了如何使这些模型对特定模态变异更具鲁棒性的修改建议。我们的发现得到了合成数据集和各种真实世界多组学数据集实验的支持。
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