Rebecca Ssengonzi, Yuye Wang, Nobuyo Maeda-Smithies, Feng Li
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引用次数: 0
Abstract
Preeclampsia (PE) is a common pregnancy-related hypertensive disorder and is a leading cause of maternal and perinatal morbidity and mortality. The incidence of PE and its associated health care costs have been increasing in the United States over the past three decades. Pregnancies complicated by PE put both the mother and child at increased risk for chronic illnesses such as cardiovascular disease, cerebrovascular disease, and cognitive impairment later in life. To date, there is no effective treatment for PE and the etiology of PE is largely unknown. While human epidemiological studies have established an association between various genetic factors and PE, a causative link between genes associated with PE and PE development has been difficult to establish. Human studies have shown that variants in eNOS (endothelial nitric oxide synthase, also known as NOS3) gene are associated with PE, and animal experimental studies have provided evidence to show the potential functional connection between the eNOS gene and PE. Here we review several studies that investigated the role of eNOS in PE, as well as studies that described how manipulating the eNOS/NO pathway could aid in disease intervention.
子痫前期(PE)是一种常见的与妊娠有关的高血压疾病,是导致孕产妇和围产期发病和死亡的主要原因。在美国,子痫前期的发病率及其相关的医疗费用在过去三十年中不断上升。妊娠合并 PE 会增加母婴罹患心血管疾病、脑血管疾病和认知障碍等慢性疾病的风险。迄今为止,还没有治疗 PE 的有效方法,而 PE 的病因在很大程度上也是未知的。虽然人类流行病学研究已经确定了各种遗传因素与 PE 之间的关联,但与 PE 相关的基因与 PE 的发病之间的因果关系却难以确定。人类研究表明,eNOS(内皮一氧化氮合酶,又称 NOS3)基因变异与 PE 相关,动物实验研究也提供了证据,表明 eNOS 基因与 PE 之间存在潜在的功能性联系。在此,我们回顾了几项调查 eNOS 在 PE 中作用的研究,以及描述操纵 eNOS/NO 通路如何有助于疾病干预的研究。