Therapeutic Potential of Aloe vera and Aloe vera-Conjugated Silver Nanoparticles on Mice Exposed to Hexavalent Chromium.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-12-01 Epub Date: 2024-03-13 DOI:10.1007/s12011-024-04105-8
Tooba Nauroze, Shaukat Ali, Shagufta Andleeb, Chaman Ara, Iqra Liaqat, Hina Mushtaq, Samaira Mumtaz, Lubna Kanwal, Afshan Syed Abbas, Shumaila Mumtaz, Muhammad Adeel Farooq, Istaqlal Hussain Khan
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Abstract

Hexavalent chromium (Cr (VI)) is a hazardous heavy metal that induces hepatotoxicity and nephrotoxicity. Thus, this study was planned to explore the ameliorating capacity of Aloe vera leaf gel extract (AV) and their conjugated silver nanoparticles (AVNP) against Cr (VI) induced hepatotoxicity and renal toxicity. The organ indices, level of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, malondialdehyde, total protein, and creatinine in blood serum were measured. The histopathological and micrometric analysis of the hepatic and renal tissue sections were studied. The hepatosomatic index was raised significantly (0.098 ± 0.13 g) in Cr treated group. The blood serum level of AST (484 ± 10.7 U/L), ALT (163 ± 5.5 U/L), ALP (336.7 ± 9.5 U/L), MDA (642.3 ± 28.3 U/L), and creatinine (4.0 ± 0.1 mg/dL) were increased significantly, whereas total protein level was declined (2.8 ± 0.3 g/dL) significantly in Cr exposed group. In the histopathological study, necrosis, disturbed hepatic cords, impaired glomeruli, and Bowman's capsule were noted. Micrometric data from the liver and kidney revealed a significant surge in the size of hepatocytes and their nuclei (1188.2 ± 467.7 µ2 and 456.5 ± 205.6 µ2) and CSA of glomeruli and Bowman's capsule (9051.8 ± 249.8 µ2 and 11,835.5 ± 336.7 µ2) in Cr (VI) exposed group, whereas the brush border (10.2 ± 4.0 µ) size declined significantly. The administration of AV and AVNP reduced the oxidative stress induced by Cr (VI).

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芦荟和芦荟共轭银纳米粒子对暴露于六价铬的小鼠的治疗潜力
六价铬(Cr (VI))是一种有害重金属,会诱发肝毒性和肾毒性。因此,本研究计划探讨芦荟叶凝胶提取物(AV)及其共轭银纳米粒子(AVNP)对六价铬诱导的肝毒性和肾毒性的改善能力。实验测定了血清中的器官指数、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶、丙二醛、总蛋白和肌酐水平。研究了肝脏和肾脏组织切片的组织病理学和显微镜分析。铬治疗组的肝功能指数明显升高(0.098 ± 0.13 g)。铬暴露组的血清 AST (484 ± 10.7 U/L)、ALT (163 ± 5.5 U/L)、ALP (336.7 ± 9.5 U/L)、MDA (642.3 ± 28.3 U/L)和肌酐 (4.0 ± 0.1 mg/dL)水平显著升高,而总蛋白水平显著下降 (2.8 ± 0.3 g/dL)。在组织病理学研究中,发现了肝脏坏死、肝索紊乱、肾小球和鲍曼囊受损。肝脏和肾脏的显微测量数据显示,铬(Ⅵ)暴露组的肝细胞及其细胞核的大小(1188.2 ± 467.7 µ2 和 456.5 ± 205.6 µ2)以及肾小球和鲍曼囊的 CSA(9051.8 ± 249.8 µ2 和 11,835.5 ± 336.7 µ2)显著增加,而刷状边界的大小(10.2 ± 4.0 µ)则明显下降。服用 AV 和 AVNP 可减少六价铬引起的氧化应激。
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CiteScore
7.20
自引率
4.30%
发文量
567
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