Atherogenic Index as a Cardiovascular Biomarker in Mexican Workers from Marginalized Urban Areas Occupationally Exposed to Metals

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Archives of Medical Research Pub Date : 2024-03-13 DOI:10.1016/j.arcmed.2024.102984
Juan Carlos Fernández-Macías , Laura Sherell Marín-Jauregui , Karen Beatriz Méndez-Rodríguez , Ana Patricia Huerta-Rodríguez , Francisco Javier Pérez-Vázquez
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Abstract

Background

Cardiovascular disease (CVD) is one of the main causes of death and disability worldwide. The etiology of CVD is often associated with multiple risk factors, with environmental factors receiving considerable attention. Individuals with precarious jobs are among the groups most affected by chronic exposure to environmental pollutants.

Aim

This study aimed to evaluate occupational exposure to heavy metals among individuals in precarious job settings and investigate atherogenic indices as biomarkers of cardiovascular risk.

Methods

A total of 137 workers participated in this cross-sectional study conducted in three work environments in San Luis Potosi, Mexico. Urine and blood samples were collected to assess metal exposure and biochemical profiles, including atherogenic indices.

Results

The results showed that workers in the brick sector exhibited the highest levels of metal exposure, particularly arsenic (44.06 µg/L), followed by stonecutters and garbage collectors (24.7 and 16.9 µg/L, respectively). Similarly, Castelli risk index (CRI) and the atherogenic index of plasma (AIP) were higher in brickmakers (3.883 and 0.499) compared to stonecutters (3.285 and 0.386) and garbage collectors (3.329 and 0.367).

Conclusions

Evidence of exposure to heavy metals was observed in the three populations, in addition to the fact that individuals with greater exposure to arsenic also exhibited higher CRI and AIP.

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作为心血管生物标志物的致动脉粥样硬化指数--来自城市边缘地区的墨西哥工人的职业接触金属情况
背景心血管疾病(CVD)是导致全球死亡和残疾的主要原因之一。心血管疾病的病因通常与多种风险因素有关,其中环境因素备受关注。本研究旨在评估工作环境不稳定人群的重金属职业暴露情况,并调查作为心血管风险生物标志物的致动脉粥样硬化指数。方法共有 137 名工人参加了这项横断面研究,研究在墨西哥圣路易斯波托西的三个工作环境中进行。结果表明,砖厂工人的金属暴露水平最高,尤其是砷(44.06 微克/升),其次是石匠和垃圾收集工(分别为 24.7 微克/升和 16.9 微克/升)。同样,制砖工人的卡斯泰利风险指数(CRI)和血浆致动脉粥样硬化指数(AIP)(3.883 和 0.499)也高于石工(3.285 和 0.386)和垃圾收集工(3.329 和 0.367)。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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