Antibiotic pollution and associated antimicrobial resistance in the environment

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL Journal of hazardous materials letters Pub Date : 2024-03-08 DOI:10.1016/j.hazl.2024.100105
Pramod Barathe , Kawaljeet Kaur , Sagar Reddy , Varsha Shriram , Vinay Kumar
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Abstract

The widespread and injudicious usage of antibiotics to contain pathogenic microbial infections, coupled with inadequate treatment of wastes containing non-metabolized antibiotics and their residues is resulting in rising environmental antibiotic concentrations, leading to ‘antibiotic pollution’. Antibiotic pollution is an emerging global challenge as it is proving a major driver for antibiotic- or antimicrobial-resistance (ABR/ AMR) with escalating ramifications worldwide, precipitating a surge in human morbidity. The extensive administration of antibiotics across domains such as human healthcare settings, agriculture, and aquaculture farming endangers the presence of antibiotics in diverse matrices including water, soil, and air. As a result, this dissemination significantly leads to the development of antibiotic resistance in the profuse sectors of the environment further provoking consequential health implications at different trophic levels. Owing to its significance, and to mitigate antibiotic pollution and its subsequential AMR, governmental guidelines and regulations are implemented across the globe to cultivate public awareness as concerted efforts for addressing this global predicament. Given the insufficient attention to the growing antibiotic pollution issues, prompt efforts must be taken to contemplate current circumstances and the rigor of the ongoing research. In this review, we endeavor to elucidate the escalation of antibiotic concentration and antibiotic-driven AMR in water, air, and soil environments with potential public health threats. Further, it focuses on various strategies and interventions to attenuate antibiotic pollution and mitigate its adverse impacts on the healthcare infrastructure, highlighting the success stories, challenges, and future directions.

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环境中的抗生素污染和相关抗生素耐药性
为遏制病原微生物感染而大量滥用抗生素,再加上对含有未代谢抗生素及其残留物的废物处理不当,导致环境中的抗生素浓度不断上升,造成 "抗生素污染"。抗生素污染是一个新出现的全球性挑战,因为它已被证明是抗生素或抗菌素耐药性(ABR/ AMR)的主要驱动因素,其后果在全球范围内不断升级,导致人类发病率激增。抗生素在人类医疗机构、农业和水产养殖业等领域的广泛使用危及到抗生素在水、土壤和空气等各种基质中的存在。因此,这种传播极大地导致了抗生素耐药性在环境各领域的发展,进一步引发了不同营养级的健康问题。鉴于抗生素污染的重要性,为了缓解抗生素污染及其引发的 AMR,全球各地都在实施政府指导方针和法规,以培养公众意识,共同努力应对这一全球性困境。鉴于人们对日益严重的抗生素污染问题关注不够,我们必须立即努力思考当前的情况和正在进行的研究的严谨性。在这篇综述中,我们试图阐明水、空气和土壤环境中抗生素浓度的上升以及抗生素驱动的 AMR 对公共健康的潜在威胁。此外,本综述还重点介绍了各种策略和干预措施,以减轻抗生素污染并减轻其对医疗保健基础设施的不利影响,同时强调了成功案例、挑战和未来方向。
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来源期刊
Journal of hazardous materials letters
Journal of hazardous materials letters Pollution, Health, Toxicology and Mutagenesis, Environmental Chemistry, Waste Management and Disposal, Environmental Engineering
CiteScore
10.30
自引率
0.00%
发文量
0
审稿时长
20 days
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