Current Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options.

IF 7.4 2区 医学 Q1 CLINICAL NEUROLOGY CNS drugs Pub Date : 2024-04-01 Epub Date: 2024-03-14 DOI:10.1007/s40263-024-01075-2
Gemma Mestre-Bach, Marc N Potenza
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Abstract

Compulsive sexual behavior disorder (CSBD) has recently been recognized as a psychiatric disorder. Pharmacological treatments for CSBD have received little study and thus have limited empirical support. The main objective of the present work is to review existing literature on the efficacy of different drugs on the symptomatology of CSBD, including the subtype of problematic pornography use (PPU). The main pharmacological approaches to treating CSBD have included opioid antagonists (naltrexone and nalmefene), selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, and sertraline), mood stabilizers (topiramate), tricyclic antidepressants (clomipramine), serotonin antagonist and reuptake inhibitors (nefazodone), and N-acetylcysteine. Since people with CSBD may experience different co-occurring disorders, these should be considered when choosing the best pharmacological treatment. Pharmacological therapy for CSBD/PPU has been suggested as an adjunct to psychological therapies, which, for the moment, have the most empirical evidence. However, to evaluate the efficacy of most of the drugs presented in this narrative review, data to date have only been available from case studies. Thus, empirical support is scant and generalizability of results is limited, highlighting the need for more research in this area.

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目前对强迫性性行为障碍和并发症的认识:临床医生应了解的药理选择。
强迫性性行为障碍(CSBD)最近被认定为一种精神疾病。针对 CSBD 的药物治疗研究很少,因此得到的经验支持有限。本研究的主要目的是回顾现有文献中不同药物对 CSBD 症状的疗效,包括对问题性色情使用(PPU)亚型的疗效。治疗 CSBD 的主要药物疗法包括阿片类拮抗剂(纳曲酮和纳美芬)、选择性血清素再摄取抑制剂(帕罗西汀、西酞普兰、氟西汀和舍曲林)、情绪稳定剂(托吡酯)、三环类抗抑郁剂(氯米帕明)、血清素拮抗剂和再摄取抑制剂(奈法唑酮)以及 N-乙酰半胱氨酸。由于 CSBD 患者可能同时患有不同的并发症,因此在选择最佳药物治疗时应考虑到这些并发症。有人建议将 CSBD/PPU 的药物疗法作为心理疗法的辅助疗法,目前,心理疗法拥有最多的实证证据。然而,要评估本综述中介绍的大多数药物的疗效,迄今为止只能从病例研究中获得数据。因此,实证支持很少,结果的推广性也很有限,这凸显了在这一领域开展更多研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CNS drugs
CNS drugs 医学-精神病学
CiteScore
12.00
自引率
3.30%
发文量
82
审稿时长
6-12 weeks
期刊介绍: CNS Drugs promotes rational pharmacotherapy within the disciplines of clinical psychiatry and neurology. The Journal includes: - Overviews of contentious or emerging issues. - Comprehensive narrative reviews that provide an authoritative source of information on pharmacological approaches to managing neurological and psychiatric illnesses. - Systematic reviews that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. - Adis Drug Reviews of the properties and place in therapy of both newer and established drugs in neurology and psychiatry. - Original research articles reporting the results of well-designed studies with a strong link to clinical practice, such as clinical pharmacodynamic and pharmacokinetic studies, clinical trials, meta-analyses, outcomes research, and pharmacoeconomic and pharmacoepidemiological studies. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in CNS Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.
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