Moringa oleifera leaf extract promotes the healing of critical sized bone defects in the mandibles of rabbits.

IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE BDJ Open Pub Date : 2024-03-14 DOI:10.1038/s41405-024-00201-y

Nouran A Elsadek, Maha A Aboukhadr, Fatma R Kamel, Hossam M Mostafa, Gillan I El-Kimary

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Abstract

Objective: The search for an osteopromotive material that enhances the efficacy of alloplasts in reconstructive surgeries has been going on for years. This study aimed to histologically and histomorphometrically evaluate the efficiency of Moringa oleifera leaf extract as an osteopromotive biomaterial.

Design: The study is a prospective randomized controlled animal study. 24 adult male New Zealand rabbits were equally allocated into test and control groups. Critical-sized bone defects were created in the edentulous areas of the mandibles of rabbits. The defects of the control group were filled with Beta-tricalcium Phosphate, while the defects of the test group were filled with Beta-tricalcium Phosphate combined with Moringa oleifera leaf extract. The results were evaluated histologically and histomorphometrically.

Results: Histological and histomorphometric analysis showed a significant increase in the surface area of bone and the number of osteoblasts in test groups compared to those in the control groups.

Conclusion: Moringa oleifera leaf extract has a positive effect on bone regeneration in critical-sized bone defects.

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油辣木叶提取物可促进兔子下颌骨临界大小骨缺损的愈合。

目的：多年来，人们一直在寻找一种骨动力材料，以增强异体材料在整形手术中的功效。本研究旨在从组织学和组织形态计量学角度评估辣木叶提取物作为骨促进生物材料的功效：本研究是一项前瞻性随机对照动物研究。将 24 只成年雄性新西兰兔平均分为试验组和对照组。试验组在兔子下颌无牙区创建临界大小的骨缺损。对照组的缺损用 Beta 磷酸三钙填充，而试验组的缺损用 Beta 磷酸三钙和辣木叶提取物混合填充。对结果进行了组织学和组织形态计量学评估：结果：组织学和组织形态计量学分析表明，与对照组相比，试验组的骨表面积和成骨细胞数量显著增加：结论：油辣木叶提取物对临界大小骨缺损的骨再生有积极作用。

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