Invade to evade: E. coli's gutsy survival strategies.

IF 18.7 Cell host & microbe Pub Date : 2024-03-13 DOI:10.1016/j.chom.2024.02.006
Yuval Mulla, Tobias Bollenbach
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Abstract

Antibiotic resistance is often studied in vitro, limiting the understanding of in vivo mechanisms that affect antibiotic treatment. In this issue of Cell Host & Microbe, Rodrigues et al. show that specific mutations allow bacteria to invade intestinal cells in a mouse model, thereby evading antibiotic treatment.

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入侵以逃避:大肠杆菌狡猾的生存策略
抗生素耐药性通常在体外进行研究,这限制了对影响抗生素治疗的体内机制的了解。在本期《细胞宿主与微生物》(Cell Host & Microbe)杂志上,Rodrigues 等人的研究表明,特定突变可使细菌入侵小鼠模型的肠道细胞,从而逃避抗生素治疗。
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