IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells

IF 0.7 Q4 HEMATOLOGY Leukemia Research Reports Pub Date : 2024-01-01 DOI:10.1016/j.lrr.2024.100454
Kazunori Nakase , Kenkichi Kita
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引用次数: 0

Abstract

Although the expression of interleukin-2 receptor α-chain (IL-2Rα, CD25) has been provided prognostic significance independent of known biomarkers in acute myeloid leukemia (AML), the functional role of CD25 molecule remains unknown. Since IL-2 can be trans-presented via CD25 to another cell, CD25+AML cells may deliver environmental IL-2 to surrounding immune cells to produce myeloid growth factors for their proliferation. We hypothesize that cellular interactions via IL-2/CD25 axis in the bone marrow microenvironment contributes to the growth advantage of these AML cells and affects the clinical outcome of those AML patients.

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IL-2/CD25 轴介导促进 CD25+ 急性髓性白血病细胞生长的细胞网络
虽然白细胞介素-2受体α-链(IL-2Rα,CD25)的表达在急性髓性白血病(AML)中具有独立于已知生物标志物的预后意义,但CD25分子的功能作用仍然未知。由于IL-2可通过CD25转呈到另一个细胞,CD25+AML细胞可能将环境中的IL-2传递给周围的免疫细胞,以产生髓系生长因子促进其增殖。我们推测,骨髓微环境中通过 IL-2/CD25 轴的细胞相互作用促成了这些急性髓细胞白血病细胞的生长优势,并影响了这些急性髓细胞白血病患者的临床预后。
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来源期刊
Leukemia Research Reports
Leukemia Research Reports Medicine-Oncology
CiteScore
1.70
自引率
0.00%
发文量
70
审稿时长
23 weeks
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