A novel fluffy PLGA/HA composite scaffold for bone defect repair

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-03-15 DOI:10.1007/s10856-024-06782-2
Yuan Tao, Meng Jia, Yang Shao-Qiang, Cheng-Teng Lai, Qian Hong, Yu Xin, Jiang Hui, Cao Qing-Gang, Xu Jian-Da, Bao Ni-Rong
{"title":"A novel fluffy PLGA/HA composite scaffold for bone defect repair","authors":"Yuan Tao,&nbsp;Meng Jia,&nbsp;Yang Shao-Qiang,&nbsp;Cheng-Teng Lai,&nbsp;Qian Hong,&nbsp;Yu Xin,&nbsp;Jiang Hui,&nbsp;Cao Qing-Gang,&nbsp;Xu Jian-Da,&nbsp;Bao Ni-Rong","doi":"10.1007/s10856-024-06782-2","DOIUrl":null,"url":null,"abstract":"<div><p>Treatment of bone defects remains crucial challenge for successful bone healing, which arouses great interests in designing and fabricating ideal biomaterials. In this regard, the present study focuses on developing a novel fluffy scaffold of poly Lactide-co-glycolide (PLGA) composites with hydroxyapatite (HA) scaffold used in bone defect repair in rabbits. This fluffy PLGA/HA composite scaffold was fabricated by using multi-electro-spinning combined with biomineralization technology. In vitro analysis of human bone marrow mesenchymal stem cells (BMSCs) seeded onto fluffy PLGA/HA composite scaffold showed their ability to adhere, proliferate and cell viability. Transplant of fluffy PLGA/HA composite scaffold in a rabbit model showed a significant increase in mineralized tissue production compared to conventional and fluffy PLGA/HA composite scaffold. These findings are promising for fluffy PLGA/HA composite scaffolds used in bone defects.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10943150/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Science: Materials in Medicine","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10856-024-06782-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Treatment of bone defects remains crucial challenge for successful bone healing, which arouses great interests in designing and fabricating ideal biomaterials. In this regard, the present study focuses on developing a novel fluffy scaffold of poly Lactide-co-glycolide (PLGA) composites with hydroxyapatite (HA) scaffold used in bone defect repair in rabbits. This fluffy PLGA/HA composite scaffold was fabricated by using multi-electro-spinning combined with biomineralization technology. In vitro analysis of human bone marrow mesenchymal stem cells (BMSCs) seeded onto fluffy PLGA/HA composite scaffold showed their ability to adhere, proliferate and cell viability. Transplant of fluffy PLGA/HA composite scaffold in a rabbit model showed a significant increase in mineralized tissue production compared to conventional and fluffy PLGA/HA composite scaffold. These findings are promising for fluffy PLGA/HA composite scaffolds used in bone defects.

Graphical Abstract

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
用于骨缺损修复的新型绒毛状 PLGA/HA 复合支架。
骨缺损治疗仍然是成功实现骨愈合的关键挑战,这引起了人们对设计和制造理想生物材料的极大兴趣。在这方面,本研究的重点是开发一种新型的聚乳酸-聚乙二醇(PLGA)与羟基磷灰石(HA)复合绒毛支架,用于兔子的骨缺损修复。这种蓬松的 PLGA/HA 复合支架是通过多电纺结合生物矿化技术制成的。体外分析表明,将人骨髓间充质干细胞(BMSCs)播种到蓬松的PLGA/HA复合支架上后,它们具有粘附、增殖和细胞存活能力。在兔子模型中移植蓬松的PLGA/HA复合支架后,矿化组织的生成量比传统和蓬松的PLGA/HA复合支架显著增加。这些发现为蓬松的 PLGA/HA 复合支架用于骨缺损带来了希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
期刊最新文献
Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality Enhancing osteogenesis and mandibular defect repair with magnesium-modified acellular bovine bone matrix Shear bond strength between dental adhesive systems and an experimental niobium-based implant material Tauroursodeoxycholic acid combined with selenium accelerates bone regeneration in ovariectomized rats A particle-filled hydrogel based on alginate and calcium phosphate nanoparticles as bone adhesive
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1