A novel fluffy PLGA/HA composite scaffold for bone defect repair

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-03-15 DOI:10.1007/s10856-024-06782-2

Yuan Tao, Meng Jia, Yang Shao-Qiang, Cheng-Teng Lai, Qian Hong, Yu Xin, Jiang Hui, Cao Qing-Gang, Xu Jian-Da, Bao Ni-Rong

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Abstract

Treatment of bone defects remains crucial challenge for successful bone healing, which arouses great interests in designing and fabricating ideal biomaterials. In this regard, the present study focuses on developing a novel fluffy scaffold of poly Lactide-co-glycolide (PLGA) composites with hydroxyapatite (HA) scaffold used in bone defect repair in rabbits. This fluffy PLGA/HA composite scaffold was fabricated by using multi-electro-spinning combined with biomineralization technology. In vitro analysis of human bone marrow mesenchymal stem cells (BMSCs) seeded onto fluffy PLGA/HA composite scaffold showed their ability to adhere, proliferate and cell viability. Transplant of fluffy PLGA/HA composite scaffold in a rabbit model showed a significant increase in mineralized tissue production compared to conventional and fluffy PLGA/HA composite scaffold. These findings are promising for fluffy PLGA/HA composite scaffolds used in bone defects.

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用于骨缺损修复的新型绒毛状 PLGA/HA 复合支架。

骨缺损治疗仍然是成功实现骨愈合的关键挑战，这引起了人们对设计和制造理想生物材料的极大兴趣。在这方面，本研究的重点是开发一种新型的聚乳酸-聚乙二醇（PLGA）与羟基磷灰石（HA）复合绒毛支架，用于兔子的骨缺损修复。这种蓬松的 PLGA/HA 复合支架是通过多电纺结合生物矿化技术制成的。体外分析表明，将人骨髓间充质干细胞（BMSCs）播种到蓬松的PLGA/HA复合支架上后，它们具有粘附、增殖和细胞存活能力。在兔子模型中移植蓬松的PLGA/HA复合支架后，矿化组织的生成量比传统和蓬松的PLGA/HA复合支架显著增加。这些发现为蓬松的 PLGA/HA 复合支架用于骨缺损带来了希望。

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.