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Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability. 姜黄素的智能纳米颗粒输送系统:提高抗癌功效和生物利用度的靶向策略。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-02-09 DOI: 10.1007/s10856-026-07012-7
Yang Fu, Yuanxin Ge, Shixiong Yi, Qifeng Peng, Heng Jiang, Jie Zhou

Curcumin, a natural polyphenol derived from Curcuma longa, exhibits potent multimodal anticancer activity by modulating critical oncogenic pathways (e.g., NF-κB, STAT3, PI3K/Akt/mTOR), inducing apoptosis, suppressing angiogenesis, and reversing multidrug resistance (MDR). However, its clinical translation is severely hindered by poor aqueous solubility, rapid metabolism, and negligible oral bioavailability (typically <1% in serum), which result in subtherapeutic concentrations at tumor sites. Smart nanoparticle delivery systems have emerged as a transformative strategy to overcome these limitations, enabling enhanced solubility, controlled release, and targeted accumulation in tumors. This review comprehensively summarizes the advancements in curcumin-loaded nanocarriers, including polymeric nanoparticles (e.g., PLGA, chitosan), lipid-based systems (e.g., liposomes, NLCs), inorganic nanoparticles (e.g., mesoporous silica, gold nanoparticles), and stimuli-responsive platforms (pH-, redox-, enzyme-sensitive). These nanosystems leverage passive targeting via the enhanced permeability and retention (EPR) effect and active targeting through ligand conjugation (e.g., folate, transferrin, hyaluronic acid), significantly improving tumor-specific delivery and curcumin's bioavailability-exemplified by a 178-fold increase in plasma AUC in healthy human volunteers following oral administration of the co-grinding formulation CUMINUP60® compared to standard crystalline curcumin. Preclinical and clinical studies demonstrate that nanoformulated curcumin synergizes with conventional chemo/radiotherapy, sensitizes resistant cancers, and modulates the immunosuppressive tumor microenvironment. For instance, Phase I/II trials indicate that formulations like nanomicellar curcumin (Sinacurcumin®) can modulate inflammatory cytokines, while liposomal variants (Lipocur™) have shown target engagement in metastatic cancers, albeit with the need for dose optimization. Hybrid nanocarriers co-delivering curcumin with chemotherapeutics or siRNA further augment therapeutic outcomes in models of colorectal, breast, pancreatic, and glioblastoma cancers. Despite these progresses, the gap between preclinical success and clinical translation remains significant. This review critically analyzes the barriers impeding commercialization, specifically highlighting the heterogeneity of the EPR effect, the lack of scalable GMP-compliant manufacturing for complex nanocarriers, and the regulatory hurdles regarding long-term biocompatibility and safety assessments.

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引用次数: 0
Magnetic nanoparticles as promising materials for the future of medicine. 磁性纳米颗粒是未来医学中很有前途的材料。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-02-09 DOI: 10.1007/s10856-025-06981-5
Fatemeh Najafi, Arezoo Maleki-Hajiagha, Nasim Kaveh Farsani, Majed Tavakkol, Akansha Sharma, Seyedeh Elaheh Sheykholeslami, Faranak Farahmand, Zahra Kazemi, Asal Katebi, Ahmad Reza Farmani, Tamim Chalati

Over the past few decades, magnetic nanoparticles (MNPs) have emerged as a focal point of research due to their versatility and diverse applications across biomedical and technological domains. The rapid advancement in nanotechnology has enabled MNPs to be utilized in drug delivery, magnetic resonance imaging (MRI), and cancer therapy. In biomedical applications, MNPs are valued for their small size, biocompatibility, and responsiveness to external magnetic fields, facilitating targeted drug delivery, cell tracking, and magnetic hyperthermia. MNPs can be functionalized with therapeutic agents for precision-targeted delivery and magneto-mechanical activation at the cellular level. This review explores the synthesis and characterization of MNPs, focusing on their therapeutic potential in cancer treatment. Iron oxide nanoparticles have been studied for their ability to target tumors through passive and active mechanisms, allowing controlled drug release within the tumor microenvironment. Coating MNPs with biocompatible materials enhances their stability and drug loading capacity while reducing toxicity. MNPs are also integrated with other nanotechnologies to create multifunctional theranostic platforms combining treatment and imaging capabilities. Despite promising preclinical results, clinical translation requires further optimization to address challenges like targeting efficiency and regulatory approval. Continued research and interdisciplinary collaboration are essential to fully realize the potential of MNPs in advancing precision medicine and improving patient outcomes.

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引用次数: 0
Fullerene C60 in dental materials: a comprehensive review of carbon nanotechnology applications and future prospects. 富勒烯C60在牙科材料中的应用:碳纳米技术的综合综述及未来展望。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-02-09 DOI: 10.1007/s10856-026-07009-2
Razieh Ghanipour, Hadi Zare-Zardini, Hossein Eslami

Teeth and dental materials are very noteworthy because of their important role in digestion and facial beauty. It is necessary to develop dental materials with suitable physical, chemical and biological properties to improve the quality and beauty of teeth. Fullerene, as a spherical allotrope of carbon, has potent properties for medical applications. In this combinatorial review article, we focus on the application of fullerene C60 in dentistry. By searching the database for suitable keywords ("fullerene", "dental" and "dentistry"), 12 related articles were found. The data extracted from these articles showed that fullerene C60 can improve the mechanical properties of dental materials, prevent bacterial and fungal infections in the mouth, reduce frictional forces during orthodontic tooth movement, reduce the oxidation of orthodontic wires, improve surface topography, and adjust the roughness of dental implants in cell proliferation and connections, reduce the overall roughness of dental implants, increase the biocompatibility of dental materials, improve osteonectography by inducing biomineralization and differentiation of osteoblasts, act as alkaline phosphatase-like catalysts and increase the concentration of phosphate ions, improve the longevity and quality of implants, reduce worn teeth and corrosion, and prevent prosthetic stomatitis and inflammation. One related study showed that the designed fullerene-based system can be used as a probe to evaluate alpha-amylase activity and serve as an alternative analytical method for caries detection. Based on this article, the future of dentistry and dental materials is bright due to the spherical nanostructure of fullerene and the development of research in the field of its use in dentistry.

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引用次数: 0
Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity. 具有多酶模拟活性的不同形态氧化铈纳米酶的抗氧化和抗炎性能研究。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-02-04 DOI: 10.1007/s10856-025-06989-x
Ziyu Song, Yuan Lu, Meihua Xiang, Ke Wen, Qian Liu

Cerium dioxide (CeO₂) nanozymes are capable of mimicking the activities of superoxide dismutase (SOD) and catalase (CAT), thereby facilitating the scavenging of reactive oxygen species (ROS). This study aims to synthesize CeO₂ nanozymes with different morphologies by controlling reaction conditions and to elucidate the relationship between morphology and antioxidant and anti-inflammatory activities of the same material. The successful preparation of CeO₂ nanozymes with different morphologies was confirmed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Our findings revealed that CeO₂ nanotubes exhibited the strongest total antioxidant capacity. More importantly, all CeO₂ nanozymes with different morphologies demonstrated excellent ROS scavenging abilities and effectively inhibited the activation of the NF-κB signaling pathway, reduced phosphorylated p65 (P-p65) protein levels, and consequently decreased the release of pro-inflammatory cytokines such as IL-6. This study not only elucidates the structure-activity-anti-inflammatory efficacy relationship of CeO₂ nanozymes but also provides a significant theoretical basis for the development of novel anti-inflammatory nanomedicines.

二氧化铈(ceo2)纳米酶能够模拟超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活性,从而促进活性氧(ROS)的清除。本研究旨在通过控制反应条件合成不同形态的CeO 2纳米酶,并阐明同种材料的形态与抗氧化、抗炎活性的关系。通过扫描电镜(SEM)、傅里叶变换红外光谱(FT-IR)和x射线衍射(XRD)等手段证实了不同形貌的CeO 2纳米酶的成功制备。我们的研究结果表明,CeO₂纳米管具有最强的总抗氧化能力。更重要的是,所有不同形态的CeO 2纳米酶都表现出优异的ROS清除能力,并能有效抑制NF-κB信号通路的激活,降低磷酸化p65 (P-p65)蛋白水平,从而减少IL-6等促炎细胞因子的释放。本研究不仅阐明了CeO 2纳米酶的结构-活性-抗炎功效关系,而且为新型抗炎纳米药物的开发提供了重要的理论依据。
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引用次数: 0
Exosome-loaded hydrogel systems for spinal cord injury repair: mechanisms, advancements, and future directions. 外泌体负载水凝胶系统用于脊髓损伤修复:机制,进展和未来方向。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-02-04 DOI: 10.1007/s10856-025-06931-1
Lang Wu, Yu Zhu, Qing Meng

Despite ongoing research efforts, spinal cord injury (SCI) remains one of the most disabling neurological disorders where current therapies provide limited solutions that mostly address symptoms rather than true regeneration. The latest research indicates that exosome-loaded hydrogel systems could function as a dual-purpose treatment for spinal cord injury in regenerative medicine. Exosomes are tiny membrane-enclosed extracellular vesicles that carry multiple therapeutic biomolecules which help control inflammation while delivering neuroprotective and tissue regenerative properties. The structural support and controlled release capabilities of hydrogels allow them to encapsulate exosomes which leads to their stable and bioactive delivery to the injury site. This study evaluates recent progress in exosome-loaded hydrogel technology for spinal cord injury repair by examining SCI mechanisms and the advantages of combining exosomes with hydrogels to develop optimized delivery systems. Our discussion will cover both the challenges of standardizing exosome production and hydrogel formulation as well as the scalability of these systems for in vivo applications. The following review will provide a summary of this novel SCI treatment approach and set out research directions to develop a therapy that is efficient, scalable, and translatable to humans.

尽管正在进行研究,脊髓损伤(SCI)仍然是最致残的神经系统疾病之一,目前的治疗方法提供的解决方案有限,主要是解决症状,而不是真正的再生。最新研究表明,外泌体负载水凝胶系统可作为再生医学中脊髓损伤的双重治疗手段。外泌体是微小的膜封闭细胞外囊泡,携带多种治疗性生物分子,有助于控制炎症,同时提供神经保护和组织再生特性。水凝胶的结构支持和控制释放能力使它们能够包裹外泌体,从而导致它们稳定和生物活性地递送到损伤部位。本研究通过考察脊髓损伤机制以及外泌体与水凝胶结合开发优化递送系统的优势,评估了外泌体负载水凝胶技术用于脊髓损伤修复的最新进展。我们的讨论将涵盖标准化外泌体生产和水凝胶配方的挑战,以及这些系统在体内应用的可扩展性。下面的综述将对这种新颖的脊髓损伤治疗方法进行总结,并提出研究方向,以开发一种高效、可扩展、可转化为人类的治疗方法。
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引用次数: 0
Efficacy and safety of a novel ab interno supraciliary HA-Mg biodegradable glaucoma drainage plate implantation in rabbit eyes. 一种新型眼睫上HA-Mg可生物降解青光眼引流板植入兔眼的疗效和安全性。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-01-29 DOI: 10.1007/s10856-026-07008-3
Yujie Rao, Minghe Xiao, Wangdu Luo, Kevin Feng, Junlong Yu, Yi Chen, Xiaomin Zhu, Shicui Xu, Shuang Yuan, Hong Liu, Cindy Hutnik, Yong Wang, Xiangji Li, Lin Xie

The uveoscleral outflow pathway is one of the important pathways for aqueous humor outflow. Implanting ab interno glaucoma drainage devices through this pathway does not require conjunctival filtering bleb formation, thereby avoiding bleb-related complications. However, permanent drainage devices can easily cause damage to the corneal endothelium. We hypothesize that a novel ab interno supraciliary HA-Mg biodegradable glaucoma drainage plate through the uveoscleral pathway can reduce corneal endothelial cell damage, demonstrate an IOP-lowering effect, and form and maintain a physiological aqueous outflow pathway after complete degradation and absorption. Sixteen New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (10 right eyes), trabeculectomy group (6 right eyes), and control group (16 left eyes). Results showed that the intraocular pressure (IOP) in the ab interno plate group was significantly lower than in the other two groups within the first 20 weeks after surgery (P < 0.0001). After 21 weeks, the IOP in the ab interno plate group gradually returned to the levels of the other two groups. Within 5 months after surgery, the plate was completely degraded and absorbed, the aqueous humor drainage pathway extended to the supraciliary space at the anterior chamber angle, and a water sac-like gap formed above the ciliary body. At the 6th month postoperatively, the number of corneal endothelial cells in the ab interno supraciliary HA-Mg drainage plate group was 2446.0 ± 104.3, and in the control group was 2391.67 ± 49.6, revealing no statistically significant difference (t = -1.611, P = 0.168). In summary, the HA-Mg biodegradable glaucoma drainage plate placement in rabbits was well fixed in the supraciliary space. After 5 months of implantation, the internal drainage plate was completely absorbed, and the implantation procedure and degradation process did not cause damage to the corneal endothelial cells. Compared with the trabeculectomy group, the ab interno plate group maintained a significantly lower IOP for a longer period in this normotensive rabbit model. Although an aqueous humor drainage channel was formed after degradation, the IOP gradually returned to the levels of the control group.

巩膜流出通道是房水流出的重要通道之一。通过该途径植入眼间青光眼引流装置不需要结膜滤过泡形成,从而避免了与泡相关的并发症。然而,永久性引流装置容易造成角膜内皮的损伤。我们假设一种新型的经巩膜通路的眼上HA-Mg可生物降解青光眼引流板可以减轻角膜内皮细胞损伤,显示出降低眼压的作用,并在完全降解吸收后形成并维持生理性的水流出通道。选取16只新西兰大白兔,随机分为三组:HA-Mg引流板组(右眼10只)、小梁切除术组(右眼6只)和对照组(左眼16只)。结果显示,术后20周内,腹板间板组眼压明显低于其他两组(P
{"title":"Efficacy and safety of a novel ab interno supraciliary HA-Mg biodegradable glaucoma drainage plate implantation in rabbit eyes.","authors":"Yujie Rao, Minghe Xiao, Wangdu Luo, Kevin Feng, Junlong Yu, Yi Chen, Xiaomin Zhu, Shicui Xu, Shuang Yuan, Hong Liu, Cindy Hutnik, Yong Wang, Xiangji Li, Lin Xie","doi":"10.1007/s10856-026-07008-3","DOIUrl":"10.1007/s10856-026-07008-3","url":null,"abstract":"<p><p>The uveoscleral outflow pathway is one of the important pathways for aqueous humor outflow. Implanting ab interno glaucoma drainage devices through this pathway does not require conjunctival filtering bleb formation, thereby avoiding bleb-related complications. However, permanent drainage devices can easily cause damage to the corneal endothelium. We hypothesize that a novel ab interno supraciliary HA-Mg biodegradable glaucoma drainage plate through the uveoscleral pathway can reduce corneal endothelial cell damage, demonstrate an IOP-lowering effect, and form and maintain a physiological aqueous outflow pathway after complete degradation and absorption. Sixteen New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (10 right eyes), trabeculectomy group (6 right eyes), and control group (16 left eyes). Results showed that the intraocular pressure (IOP) in the ab interno plate group was significantly lower than in the other two groups within the first 20 weeks after surgery (P < 0.0001). After 21 weeks, the IOP in the ab interno plate group gradually returned to the levels of the other two groups. Within 5 months after surgery, the plate was completely degraded and absorbed, the aqueous humor drainage pathway extended to the supraciliary space at the anterior chamber angle, and a water sac-like gap formed above the ciliary body. At the 6th month postoperatively, the number of corneal endothelial cells in the ab interno supraciliary HA-Mg drainage plate group was 2446.0 ± 104.3, and in the control group was 2391.67 ± 49.6, revealing no statistically significant difference (t = -1.611, P = 0.168). In summary, the HA-Mg biodegradable glaucoma drainage plate placement in rabbits was well fixed in the supraciliary space. After 5 months of implantation, the internal drainage plate was completely absorbed, and the implantation procedure and degradation process did not cause damage to the corneal endothelial cells. Compared with the trabeculectomy group, the ab interno plate group maintained a significantly lower IOP for a longer period in this normotensive rabbit model. Although an aqueous humor drainage channel was formed after degradation, the IOP gradually returned to the levels of the control group.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":"33"},"PeriodicalIF":4.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication and characterization of biodegradable Zn-Ni spinel ferrite/ β-TCP composite ceramics exhibiting enhanced cell colonization. 生物可降解锌镍尖晶石铁氧体/ β-TCP复合陶瓷的制备与表征
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-01-29 DOI: 10.1007/s10856-026-07004-7
Piyapong Pankaew, Poomirat Nawarat, Jaroenporn Chokboribal

Via a solid-state reaction route, magnetic composites of chicken eggshell-derived β-tricalcium phosphate (β-TCP, referred to as TCP in the composite system) and zinc-nickel spinel ferrite (ZNF; ZnxNi1‒xFe2O4, x = 0.2, 0.4, 0.6, or 0.8) were successfully fabricated. Discs were prepared by uniaxial pressing of milled ZNF/TCP powders and sintered at 1200 °C. Cytocompatibility of all composites was confirmed by SEM observations of human osteoblasts (h-OBs) and MTT assays. At 4-wt% ZNF addition, the composites containing Zn0.8Ni0.2Fe2O4 (Z8NF) exhibited the greatest extent of early cell spreading and were selected for further investigation. For Z8NF/TCP composites containing 4-12 wt% Z8NF, the 8-12 wt% samples demonstrated the highest levels of cell colonization, while MTT assays suggested non-cytotoxic behavior, with cell viabilities comparable to β-TCP. High-temperature sintering induced partial transformation of β-TCP to β-calcium pyrophosphate (β-CPP), as evidenced by XRD and Rietveld refinement. Increasing Z8NF content promoted β-CPP formation and increased composite porosity, whereas densification and Vickers hardness decreased accordingly. Rietveld refinement further indicated that the detectable crystalline Z8NF phase persisted as a minor yet stable secondary phase ( < 2 wt%) and did not participate in Ca-P lattice substitution. For the 8-12 wt% composites, saturation magnetization decreased with increasing Z8NF because of higher porosity and dilution by the non-magnetic β-TCP/β-CPP matrix, while coercivity increased owing to enhanced effective magnetic anisotropy in the more porous microstructure. Overall, the Z8NF/TCP composites combined biodegradability, bioactivity, and tunable soft-magnetic properties, suggesting their potential for bone repair and bone tissue engineering applications.

通过固相反应途径,成功制备了由鸡蛋壳衍生的β-磷酸三钙(β-TCP,复合体系中简称TCP)与锌镍尖晶石铁素体(ZNF; ZnxNi1-xFe2O4, x = 0.2、0.4、0.6或0.8)组成的磁性复合材料。采用单轴挤压法制备ZNF/TCP粉,并在1200℃下烧结。所有复合材料的细胞相容性通过人成骨细胞扫描电镜观察(h-OBs)和MTT测定证实。当ZNF添加量为4 wt%时,Zn0.8Ni0.2Fe2O4 (Z8NF)的复合材料表现出最大程度的早期细胞扩散,并被选作进一步研究。对于含有4-12 wt% Z8NF的Z8NF/TCP复合材料,8-12 wt%的样品显示出最高水平的细胞定植,而MTT试验显示无细胞毒性行为,细胞存活率与β-TCP相当。高温烧结诱导β-TCP部分转变为β-焦磷酸钙(β-CPP), XRD和Rietveld细化证实了这一点。Z8NF含量的增加促进了β-CPP的形成,提高了复合材料孔隙率,致密化程度和维氏硬度相应降低。Rietveld细化进一步表明,可检测到的结晶Z8NF相作为次要但稳定的二次相存在(
{"title":"Fabrication and characterization of biodegradable Zn-Ni spinel ferrite/ β-TCP composite ceramics exhibiting enhanced cell colonization.","authors":"Piyapong Pankaew, Poomirat Nawarat, Jaroenporn Chokboribal","doi":"10.1007/s10856-026-07004-7","DOIUrl":"10.1007/s10856-026-07004-7","url":null,"abstract":"<p><p>Via a solid-state reaction route, magnetic composites of chicken eggshell-derived β-tricalcium phosphate (β-TCP, referred to as TCP in the composite system) and zinc-nickel spinel ferrite (ZNF; Zn<sub>x</sub>Ni<sub>1‒x</sub>Fe<sub>2</sub>O<sub>4</sub>, x = 0.2, 0.4, 0.6, or 0.8) were successfully fabricated. Discs were prepared by uniaxial pressing of milled ZNF/TCP powders and sintered at 1200 °C. Cytocompatibility of all composites was confirmed by SEM observations of human osteoblasts (h-OBs) and MTT assays. At 4-wt% ZNF addition, the composites containing Zn<sub>0.8</sub>Ni<sub>0.2</sub>Fe<sub>2</sub>O<sub>4</sub> (Z8NF) exhibited the greatest extent of early cell spreading and were selected for further investigation. For Z8NF/TCP composites containing 4-12 wt% Z8NF, the 8-12 wt% samples demonstrated the highest levels of cell colonization, while MTT assays suggested non-cytotoxic behavior, with cell viabilities comparable to β-TCP. High-temperature sintering induced partial transformation of β-TCP to β-calcium pyrophosphate (β-CPP), as evidenced by XRD and Rietveld refinement. Increasing Z8NF content promoted β-CPP formation and increased composite porosity, whereas densification and Vickers hardness decreased accordingly. Rietveld refinement further indicated that the detectable crystalline Z8NF phase persisted as a minor yet stable secondary phase ( < 2 wt%) and did not participate in Ca-P lattice substitution. For the 8-12 wt% composites, saturation magnetization decreased with increasing Z8NF because of higher porosity and dilution by the non-magnetic β-TCP/β-CPP matrix, while coercivity increased owing to enhanced effective magnetic anisotropy in the more porous microstructure. Overall, the Z8NF/TCP composites combined biodegradability, bioactivity, and tunable soft-magnetic properties, suggesting their potential for bone repair and bone tissue engineering applications.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":"31"},"PeriodicalIF":4.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing bone repair ability of 3D-printed PLLA scaffolds via N-methyl-2-pyrrolidone etching. n -甲基-2-吡咯烷酮蚀刻增强3d打印PLLA支架骨修复能力。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-01-28 DOI: 10.1007/s10856-026-07005-6
Wang Yuanzheng, Jiang Qilin, Huang Xin, Wu Shaohong, Li Jinlong, Cao Jian, Liu Zhongxing

The development of bone repair scaffolds has long been a research hotspot in tissue engineering. Owing to its unique capability for personalized customization of scaffold geometry and microstructure, 3D printing technology has been extensively adopted for fabricating bone repair scaffolds. Poly-L-lactic acid (PLLA), endowed with favorable biodegradability, excellent biocompatibility, and reliable in vivo safety, is widely used as a matrix material for 3D printed bone repair scaffolds. PLLA is a bioinert polymer characterized by inferior cell adhesion and osteogenic differentiation capabilities. To mitigate this bioinertness limitation, the present study employed N-methylpyrrolidone (NMP) etching to modify the surface of 3D-printed PLLA bone repair scaffolds. Following NMP etching for 1-24 h, the originally smooth scaffold surface evolved into a hierarchical, petal-like gradient microstructure, accompanied by a marked increase in surface roughness. Correspondingly, the hydrophilicity of the treated scaffolds was also enhanced. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses further confirmed that the crystallinity of PLLA in the scaffolds was significantly enhanced. Concomitantly, the modified scaffolds exhibited a marked improvement in adsorption capacity for green fluorescent protein (GFP), while the adhesion and proliferation of MC3T3-E1 on their surface were also significantly promoted. In vivo animal experiments demonstrated that the NMP-etched scaffolds could accelerate the process of bone defect repair. Collectively, surface modification of 3D-printed PLLA bone scaffolds via NMP etching enables precise modulation of their physicochemical properties, thereby effectively mitigating the inherent bioinertness limitation of PLLA scaffolds.

骨修复支架的开发一直是组织工程领域的研究热点。3D打印技术由于其独特的对支架几何形状和微观结构进行个性化定制的能力,已被广泛应用于骨修复支架的制造。聚l -乳酸(PLLA)具有良好的生物可降解性、优异的生物相容性和可靠的体内安全性,被广泛用作3D打印骨修复支架的基质材料。聚乳酸是一种生物惰性聚合物,其特点是细胞粘附能力和成骨分化能力较差。为了减轻这种生物惰性的限制,本研究采用n -甲基吡咯烷酮(NMP)蚀刻来修饰3d打印PLLA骨修复支架的表面。在NMP蚀刻1-24小时后,原本光滑的支架表面演变成层次化的花瓣状梯度微观结构,同时表面粗糙度显著增加。相应的,处理后的支架的亲水性也增强了。差示扫描量热法(DSC)和x射线衍射(XRD)分析进一步证实了支架中PLLA的结晶度明显增强。同时,修饰后的支架对绿色荧光蛋白(GFP)的吸附能力显著提高,MC3T3-E1在其表面的粘附和增殖能力也显著增强。体内动物实验表明,nmp刻蚀支架可以加速骨缺损的修复过程。总之,通过NMP蚀刻对3d打印PLLA骨支架进行表面修饰,可以精确调节其物理化学性质,从而有效减轻PLLA支架固有的生物惰性限制。
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引用次数: 0
Correction to : Synthesis, and evaluation of photophysical properties of a potential DPP-derived photosensitizer for photodynamic therapy with D-A-D architecture 修正:一种潜在的dpp衍生光敏剂的合成和光物理性质的评价,用于D-A-D结构的光动力治疗。
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-01-27 DOI: 10.1007/s10856-025-06873-8
Vanessa Escalona Hernández, Itzia Irene Padilla-Martínez, Rosa Angeles Vázquez García, María Aurora Veloz Rodríguez, Oscar Javier Hernández-Ortiz
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引用次数: 0
The effect of nitrogen atmosphere during post-curing on cytotoxicity, polishability, flexural strength, and surface hardness of 3D-printed denture bases: an in vitro study 后固化过程中氮气气氛对3d打印义齿基托细胞毒性、可抛光性、抗弯强度和表面硬度的影响:一项体外研究
IF 4.5 3区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2026-01-26 DOI: 10.1007/s10856-026-07006-5
Karoline Gladrow, Alexey Unkovskiy, Jamila Yassine, Nora Gaertner, Ievgeniia Topolniak, Nico Henning, Franziska Schmidt

3D printing is increasingly utilized in dentistry. Compared to traditional manufacturing methods, 3D printing provides advantages such as faster production times and the ability to create complex structures. Although biocompatible materials are available, many are only suitable for temporary applications. This study examines the impact of nitrogen-aided post-processing on the mechanical properties and cytotoxicity of 3D-printed denture bases, with the hypothesis that this post-processing will enhance material properties and decrease cytotoxicity. Specimens were fabricated from V-print dentbase (Voco GmbH, Cuxhaven, Germany) and post-processed either in nitrogen or air. The specimens were categorized into aged and non-aged groups. For comparison, specimens made from milled material were utilized. Vickers hardness, flexural strength, polishability, cytotoxicity, and degree of conversion were then assessed for all groups. The data were analyzed using a one-way ANOVA and Tukey HSD test for multiple comparisons, with a significance threshold of p < 0.05. Post-curing with nitrogen improved the degree of conversion, surface hardness, and biocompatibility of 3D-printed dental materials, confirming reduced cytotoxicity without impairing mechanical properties. Nitrogen increased polymerization and decreased harmful monomers, making it ideal for clinical applications in contact with the oral mucosa. Optimizing post-processing steps, such as curing in nitrogen, enhances biocompatibility while maintaining strength and hardness, ensuring better patient care in dental applications.

3D打印越来越多地应用于牙科。与传统制造方法相比,3D打印具有更快的生产时间和创建复杂结构的能力等优势。虽然生物相容性材料是可用的,但许多只适合临时应用。本研究考察了氮辅助后处理对3d打印义齿基托机械性能和细胞毒性的影响,并假设这种后处理将提高材料性能并降低细胞毒性。样品由V-print牙基(Voco GmbH, Cuxhaven, Germany)制成,并在氮气或空气中进行后处理。标本分为老年组和非老年组。为了进行比较,使用了由铣削材料制成的标本。然后对所有组进行维氏硬度、抗弯强度、抛光性、细胞毒性和转化程度的评估。数据分析采用单因素方差分析和多重比较的Tukey HSD检验,显著性阈值为p
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引用次数: 0
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