Medication-associated orbital inflammation: A systematic review

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY Survey of ophthalmology Pub Date : 2024-03-13 DOI:10.1016/j.survophthal.2024.03.003
Terence Ang MBBS , Viraj Chaggar , Jessica Y. Tong FRANZCO , Dinesh Selva DHSc FRANZCO FRACS
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Abstract

We performed a comprehensive systematic review to identify medication-associated orbital inflammation and to characterize its clinico-radiological features. We reviewed English-language articles describing medication-associated orbital inflammation (i.e., orbital myositis, dacryoadenitis and orbital fat) published to June, 2023. Isolated inflammation of the intraocular structures or globe alone (i.e. uveitis, scleritis, optic neuritis and perineuritis) were excluded. In medication-associated orbital inflammation, the extraocular muscles are preferentially affected, occurring in isolation or in combination with other orbital and/or intraocular structures. Clinico-radiological manifestations may be non-specific; however, certain medications may be distinguished according to the presence of systemic prodrome, laterality, associated intraocular inflammation, and predisposition to involve certain orbital structures. Rapid identification, discontinuation of the provoking medication, and systemic corticosteroid therapy (if appropriate) typically achieves a favorable visual prognosis. As new medications become adopted by clinicians, rare adverse effects will be further delineated.Medication-associated orbital inflammation is an important diagnostic consideration in orbital inflammatory disease. A careful medication history and clinical assessment may be revealing, permitting timely discontinuation of the offending agent and initiation of appropriate management.

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我们进行了一项全面的系统性综述,以确定药物相关性眼眶炎症并描述其临床放射学特征。我们回顾了截至 2023 年 6 月发表的描述药物相关眼眶炎症(即眼眶肌炎、泪腺炎和眼眶脂肪)的英文文章。眼内结构或眼球的单独炎症(即葡萄膜炎)、巩膜炎、视神经炎和神经周围炎均被排除在外。在药物相关性眼眶炎症中,眼外肌优先受到影响,可单独发生,也可与其他眼眶和/或眼内结构同时发生。临床放射学表现可能是非特异性的;然而,某些药物可根据是否存在全身性前驱症状、偏侧性、相关眼内炎症以及累及某些眼眶结构的易感性加以区分。快速识别、停用诱发药物和全身性皮质类固醇治疗(如果合适)通常可以获得良好的视觉预后。随着新药物被临床医生所采用,罕见的不良反应也将被进一步描述。与药物相关的眼眶炎症是眼眶炎症性疾病诊断的一个重要考虑因素。仔细的用药史和临床评估可能会有所启发,从而及时停用违规药物并采取适当的治疗措施。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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