Survey of ophthalmology最新文献

{"title":"The downside of tamponade: Silicone oil emulsification and its ocular impact","authors":"Chaitra Jayadev,&nbsp;Karishma Tendulkar,&nbsp;Shruthi Vidyasagar,&nbsp;Vedant Gambhir,&nbsp;Vishma Prabhu,&nbsp;Prathibha Hande,&nbsp;Ramesh Venkatesh","doi":"10.1016/j.survophthal.2025.12.001","DOIUrl":"10.1016/j.survophthal.2025.12.001","url":null,"abstract":"<div><div>Silicone oil (SO) remains an essential intraocular tamponade in vitreoretinal surgery, particularly for complex retinal detachments; however, its long-term use is associated with significant complications, of which emulsification is the most clinically impactful. We offer a comprehensive synthesis of the pathophysiology, clinical presentation, imaging features, and management of SO emulsification. We begin by outlining the chemical structure and biophysical properties of SO, emphasizing the role of viscosity, interfacial tension, and molecular purity in emulsification resistance. The manufacturing process and its relevance to residual impurities, including surfactant-like components, are highlighted as critical contributors to emulsification risk. Clinical risk factors spanning preoperative inflammation, intraoperative techniques, and postoperative dynamics are detailed. Multimodal imaging including optical coherence tomography, ultrasound biomicroscopy, and fundus autofluorescence provides diagnostic insight into emulsified SO, while standardized grading systems offer a framework for clinical assessment. We also address pharmacokinetic alterations in SO-filled and emulsified eyes, impacting drug distribution and efficacy of anti-vascular endothelial growth factor agents, steroids, and antimicrobials. Management strategies include individualized algorithmic decision-making approach regarding the timing and technique of SO removal, acknowledging the challenges in achieving complete elimination of microdroplets. Emerging innovations in SO formulations, surface modifications, fluorinated oils, and AI-driven imaging tools are discussed as future solutions. Ultimately, our review underscores the need for an integrative approach combining material science, surgical expertise, and personalized care to mitigate the complications of SO emulsification and optimize long-term outcomes in retinal surgery.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 803-816"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective validation of deep-learning algorithms for diabetic retinopathy screening: A systematic review and meta-analysis","authors":"Ting-Wei Wang ,&nbsp;Wei-Ting Luo ,&nbsp;Yu-Kang Tu ,&nbsp;Yu-Bai Chou ,&nbsp;Yu-Te Wu","doi":"10.1016/j.survophthal.2025.11.012","DOIUrl":"10.1016/j.survophthal.2025.11.012","url":null,"abstract":"<div><div>Deep-learning (DL) algorithms are widely promoted for diabetic-retinopathy (DR) screening, yet their prospective diagnostic accuracy is not well defined. PubMed, EMBASE and ClinicalTrials.gov were searched to April, 2025, for prospective evaluations of DL systems using color-fundus images. Two reviewers screened records, extracted data, and applied QUADAS-2. Hierarchical bivariate random-effects models produced pooled sensitivity and specificity for referable and vision-threatening DR), analyzed separately at patient and eye level. Twenty-one prespecified moderators were explored with uni- and multi-variate meta-regression; publication bias was assessed with Deeks’ test Seventy-three studies from 23 countries (255,330 examinations) met the criteria. Pooled patient-level sensitivity was 0.94 (95 % CI 0.92–0.95) and specificity 0.90 (95 % CI 0.87–0.93); eye-level values were 0.93 (95 % CI 0.91–0.95) and 0.94 (95 % CI 0.92–0.96). DR subtype, retinal-field strategy, camera form factor, and prevalence independently explained heterogeneity (p &lt; 0.05). Performance matched or exceeded pivotal FDA trials (IDx-DR, EyeArt). AI gradability was ≥ 95 % in 60 % of cohorts, including handheld and smartphone systems. DL-based DR screening achieves consistent, high accuracy across devices and care settings, enabling scalable deployment in primary care, pharmacies, and mobile clinics. Quality assurance and ongoing monitoring are essential to maximize population-level benefits.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 827-846"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness and safety of intra-arterial chemotherapy and intravenous chemotherapy for retinoblastoma: A systematic review and meta-analysis","authors":"Kai-Yang Chen ,&nbsp;Hoi-Chun Chan ,&nbsp;Chi-Ming Chan MD, PhD","doi":"10.1016/j.survophthal.2025.12.009","DOIUrl":"10.1016/j.survophthal.2025.12.009","url":null,"abstract":"<div><div>Intra-arterial chemotherapy (IAC) has emerged as a targeted alternative to intravenous chemotherapy (IVC) for retinoblastoma; however, the comparative effectiveness and safety of these approaches remain incompletely defined. We performed a systematic review and meta-analysis to evaluate whether IAC-based regimens are associated with improved clinical outcomes compared with IVC in pediatric retinoblastoma. Twelve studies were included. Comparative studies contributed to the quantitative synthesis, whereas selected non comparative IAC series were summarized qualitatively to provide contextual evidence. Overall survival demonstrated a consistent association favoring IAC across both early and advanced disease categories, with a pooled effect estimate of OR 4.72 (95% CI 2.69–8.28). In early-stage disease, the pooled OR was 12.61 (95% CI 3.82–41.58), while advanced-stage disease showed a pooled OR of 3.56 (95% CI 1.88–6.74). Heterogeneity was negligible within subgroups (I² = 0%). Event-free survival favored IAC-based treatment overall with a pooled RR of 1.36 (95% CI 1.13–1.62). When stratified by treatment approach, IAC alone showed a pooled RR of 1.30 (95% CI 1.01–1.66) with moderate heterogeneity (I² = 61%), whereas IAC combined with IVC sequencing demonstrated a pooled RR of 1.43 (95% CI 1.10–1.86) with no heterogeneity (I² = 0%). Globe salvage outcomes were improved with IAC, with a pooled RR of 1.33 (95% CI 1.23–1.42; I² = 9%). Avoidance of enucleation also favored IAC overall, with a pooled RR of 1.69 (95% CI 1.34–2.12). Subgroup analyses indicated a modest and non-significant effect in early-stage disease (RR 1.27, 95% CI 0.89–1.80) and a clearer effect in advanced-stage disease (RR 2.08, 95% CI 1.54–2.80), with minimal heterogeneity (I² = 0%). Metastatic events were rare across studies; nevertheless, pooled analysis suggested lower odds of metastasis in IAC-based regimens compared with IVC (OR 0.42, 95% CI 0.19–0.91; I² = 0%), with no evidence of subgroup differences between IAC alone and IAC plus IVC sequencing. In conclusion, IAC-based strategies were associated with favorable outcomes in survival, disease control, globe salvage, and avoidance of enucleation compared with IVC, with consistently low heterogeneity across major endpoints and metastatic events remaining uncommon in both arms. These findings support the role of IAC as an important component of contemporary retinoblastoma management, particularly in settings with appropriate technical expertise and multidisciplinary resources.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 878-891"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography angiogropahy changes in patients with diabetic retinopathy treated with panretinal photocoagulation: A systematic review and meta-analysis","authors":"Chang Zhang ,&nbsp;Zhe Xia ,&nbsp;Wenxuan Mao ,&nbsp;Zushun Lin ,&nbsp;Wei Lin ,&nbsp;Jiayu Zhang ,&nbsp;Zhong Lin","doi":"10.1016/j.survophthal.2025.11.005","DOIUrl":"10.1016/j.survophthal.2025.11.005","url":null,"abstract":"<div><div>We evaluated retinal microvascular changes in patients with diabetic retinopathy (DR) treated with panretinal photocoagulation (PRP), using optical coherence tomography angiography (OCTA). Nineteen studies were included that assess changes in vessel density (VD) within the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the foveal avascular zone (FAZ) area. PRP was associated with a significant increase in VD in the SCP, particularly in the foveal region, with greater improvements observed during long-term follow-up. In contrast, changes in the DCP were less consistent; however, a mild increase in foveal VD was noted over time. Additionally, a borderline reduction in FAZ area was observed after PRP, suggesting enhanced macular perfusion. These findings highlight the localized and time-dependent vascular effects of PRP and support the use of OCTA as a non-invasive, layer-specific tool for monitoring treatment outcomes in DR.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 847-857"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudophakic macular edema: Review and new insights on treatment and prophylaxis","authors":"António Campos ,&nbsp;Carolina Mota ,&nbsp;Henrique Cruz ,&nbsp;João Paulo Sousa","doi":"10.1016/j.survophthal.2025.11.001","DOIUrl":"10.1016/j.survophthal.2025.11.001","url":null,"abstract":"<div><div>Pseudophakic cystoid macular edema (PCME) is a common complication of cataract surgery that may rarely result in vision loss. In most cases PCME resolves spontaneously, which makes it challenging to establish the efficacy of therapeutic and prophylactic interventions. Although no consensus exists regarding management or prevention, most surgeons advocate prophylaxis primarily for high-risk eyes. Nevertheless, the costs associated with preventive measures have risen substantially in recent years. In this review, we summarize the current evidence on the epidemiology, pathogenesis, diagnosis, risk factors, treatment, and prophylaxis of PCME, to provide a comprehensive understanding of its clinical indications and the cost-effectiveness of available strategies.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 817-826"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and clinical utility of ultrasound biomicroscopy in extraocular muscle imaging: A systematic review and meta-analysis","authors":"Arash Mirmohammadsadeghi ,&nbsp;Erfan Sadeghi ,&nbsp;Mohammad Reza Akbari ,&nbsp;Motahhareh Sadeghi ,&nbsp;Babak Masoomian ,&nbsp;Raziyeh Farrokhi ,&nbsp;Alireza Sahraian","doi":"10.1016/j.survophthal.2025.11.011","DOIUrl":"10.1016/j.survophthal.2025.11.011","url":null,"abstract":"<div><div>We evaluate the accuracy of ultrasound biomicroscopy (UBM) for localizing extraocular muscle (EOM) insertions and factors affecting its diagnostic performance. We conducted a systematic search across 5 databases from January, 2000, to December, 2024, identifying studies that compared UBM measurements with intraoperative caliper measurements in strabismus surgery. Pooled accuracy was defined as the proportion of UBM measurements within 1 mm of the intraoperative reference measurements. Pooled accuracy and 95 % confidence interval were estimated using a random-effects model, with between-study variance (τ²) calculated via the restricted maximum likelihood method. Subgroup analyses and meta-regression were performed to investigate sources of heterogeneity, including population characteristics, imaging timing, surgery type, and muscle type. Eleven studies (616 measurements) met inclusion criteria. The pooled accuracy of UBM was 79 % (95 % CI: 70–87 %), with substantial heterogeneity (I² = 83.8 %). Preoperative imaging showed significantly higher accuracy (83 %) than postoperative (62 %; p = 0.0018). UBM achieved 82 % accuracy in primary surgeries and 69 % in reoperations (p = 0.0173). In pediatric populations, accuracy reached 88 % (95 % CI: 63–100 %), but subgroup differences were not statistically significant (p = 0.3355). Meta-regression analysis indicated that population, imaging timing, and surgery type collectively explained 41 % of the variability in UBM accuracy. Nevertheless, substantial heterogeneity remained unexplained. UBM demonstrates context-dependent accuracy for EOM localization, with reduced performance in reoperations and postoperative settings. Selective use is recommended, potentially in combination with anterior segment optical coherence tomography for reoperations. Persistent heterogeneity and methodological variations highlight the need for standardized protocols and further research.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 951-959"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the 3 pillars of housing for eye and vision health outcomes: A scoping review","authors":"Sofia E. Parellada MS ,&nbsp;Kishan Avaiya BS ,&nbsp;Khawla M. Elnour BS ,&nbsp;Mikhayla L. Armstrong BA ,&nbsp;Tiffani R. Spaulding MD MPH ,&nbsp;Kate M. Saylor MSI ,&nbsp;Maria A. Woodward MD MS ,&nbsp;Angela R. Elam MD MPH ,&nbsp;Roshanak Mehdipanah PhD MS ,&nbsp;Paula Anne Newman-Casey MD MS ,&nbsp;Patrice M. Hicks PhD MPH","doi":"10.1016/j.survophthal.2025.12.008","DOIUrl":"10.1016/j.survophthal.2025.12.008","url":null,"abstract":"<div><div>In this scoping review, we examine the implications of 3 pillars (housing conditions and quality, residential consistency, and housing affordability) of healthy housing on vision health outcomes. We examine barriers based on geographical locations of the studies and World Health Organization income levels. We identified 11,190 abstracts, with 10,996 articles retrieved. Sixty-three met inclusion criteria. Among these, housing conditions emerged as the most frequently observed housing pillar associated with adverse vision health outcomes, cited in 62.1 % of the studies. Environmental pollution, particularly indoor air quality and exposure to harmful substances, was the most common condition associated with poor vision outcomes.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 997-1005"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal nerve fiber layer thickness as a biomarker of uveitis activity: A systematic review","authors":"Amin Nabavi MD, FICO ,&nbsp;Luis J. Haddock MD ,&nbsp;Alireza Mahmoudi MD ,&nbsp;Mirataollah Salabati MD ,&nbsp;Siamak Yousefi PhD, FARVO","doi":"10.1016/j.survophthal.2025.12.002","DOIUrl":"10.1016/j.survophthal.2025.12.002","url":null,"abstract":"<div><div>Optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer thickness (pRNFL) has emerged as a promising surrogate for inflammatory activity in uveitis. We conducted a PRISMA-compliant systematic search of PubMed and Embase to identify studies that measured pRNFL in infectious and noninfectious uveitis. Twenty-three studies comprising 2632 eyes met our criteria. Risk of bias was appraised with the ROBINS-I tool and ranged from low to serious, predominantly moderate (13/23) and serious (9/23). Between study heterogeneity was substantial across OCT platforms, anatomic locations, and etiologies. In cross-sectional cohorts, eyes with active uveitis demonstrated an average pRNFL thickening ranging from + 12 to + 44 µm in adults and 8–25 µm in children, when compared with inactive, fellow, or healthy control eyes. Optic discs with angiographic leakage had greater pRNFL thickness, and in one pediatric series, a pRNFL threshold of 130 µm achieved 79 % sensitivity and 85 % specificity for detecting optic disc leakage. Longitudinal analyses demonstrated reversibility of pRNFL thickening, with reductions ranging from approximately 6–47 % of baseline values as inflammation subsided over 1–12 months. Thickening was most pronounced in intermediate, posterior, and panuveitic eyes and least pronounced in isolated anterior uveitis, whereas Fuchs uveitis syndrome showed little or no change. These findings indicate that pRNFL thickening may reflect uveitic activity and warrant further validation.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 858-867"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out of sight, hiding in plain clues","authors":"Laia Peraferrer-Montesinos ,&nbsp;Silvia Susin-Calle ,&nbsp;Jose E. Martínez-Rodríguez ,&nbsp;Marta Saint-Gerons ,&nbsp;John J. Chen","doi":"10.1016/j.survophthal.2025.11.006","DOIUrl":"10.1016/j.survophthal.2025.11.006","url":null,"abstract":"<div><div>A 76-year-old man with advanced non-small cell lung carcinoma undergoing treatment with carboplatin and paclitaxel plus pembrolizumab presented to the emergency department with a one-week history of rapidly progressive, severe bilateral visual loss and pain on eye movement. Ocular movements were full, with no other neurological deficits noted. Visual acuity was reduced bilaterally: 20/63 right eye, 20/200 left eye. Color vision testing was borderline normal, bilateral visual fields were constricted, while both funduscopy and optical coherence tomography were unremarkable. Urgent magnetic resonance imaging of the brain revealed patchy FLAIR hyperintensities in both optic nerves and faint post-contrast enhancement. By the time of neurological assessment one week later, the patient had experienced partial spontaneous improvement in vision. A comprehensive neuro-oncological differential diagnosis was performed, prompting the request for further diagnostic tests. This case illustrates the evolving landscape of neuro-oncology, where advances in diagnostic approaches and the use of immunotherapies such as pembrolizumab may alter immune tolerance, leading to immune-related adverse events such as myelin oligodendrocyte glycoporotein antibody-associated disease.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 1006-1009"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on surgical and nonsurgical innovations for macular hole treatment","authors":"Giulia Grieco MD, FEBO ,&nbsp;Matteo Mario Carlà MD, FEBO ,&nbsp;Gaetano Di Stefano MD, FEBO ,&nbsp;Alessandra Scampoli MD ,&nbsp;Lorenzo Governatori MD ,&nbsp;Beatrice Tombolini MD, FEBO ,&nbsp;Paolo Radice MD ,&nbsp;Stanislao Rizzo MD, PhD ,&nbsp;Tomaso Caporossi MD, PhD","doi":"10.1016/j.survophthal.2025.11.008","DOIUrl":"10.1016/j.survophthal.2025.11.008","url":null,"abstract":"<div><div>We explore the evolving landscape of macular hole (MH) management, highlighting key advancements in surgical and nonsurgical treatments. While pars plana vitrectomy with internal limiting membrane (ILM) peeling remains the gold standard for MH less than 500 μm in width and in chronic or highly myopic cases, novel techniques have expanded treatment options, including ILM flap approaches, biomaterial grafts, and regenerative therapies. Additionally, emerging nonsurgical modalities, such as pharmacological agents and stem cell-based therapies, present promising alternatives. We synthesize the current evidence in MH management, focusing on clinical implications and limitations of each technique. Furthermore, we discuss future directions to optimize anatomical and functional outcomes of complex and refractory MHs.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"71 3","pages":"Pages 793-802"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145522875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}