Suppression of P2X4 and P2X7 by Lactobacillus rhamnosus vitaP1: effects on hangover symptoms.

IF 3.5 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY AMB Express Pub Date : 2024-03-15 DOI:10.1186/s13568-024-01685-5

Jeong Eun Kwon, Woojae Hong, Hyelin Jeon, Cha Soon Kim, Hyunggun Kim, Se Chan Kang

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Abstract

This study aimed to identify substances including Lactobacillus rhamnosus vitaP1 (KACC 92054P) that alleviate hangover-induced emotional anxiety and liver damage. The association between emotional anxiety caused by hangover and the genes P2X4, P2X7, SLC6A4 was investigated. In vitro and in vivo analyses were conducted to assess the influence of free-panica on alcohol-induced upregulated gene expression. Additionally, the concentration of AST, ALT, alcohol, and acetaldehyde in blood was measured. Free-panica, consisting of five natural products (Phyllanthus amarus, Phoenix dactylifera, Vitis vinifera, Zingiber officinale, and Lactobacillus rhamnosus), were evaluated for their regulatory effects on genes involved in alcohol-induced emotional anxiety and liver damage. The combination of these natural products in free-panica successfully restored emotional anxiety, and the concentration of AST, ALT, alcohol, and acetaldehyde in blood to those of the normal control group. These findings support the potential development of free-panica as a health functional food or medicinal intervention for relieving hangover symptoms and protecting liver from alcohol consumption.

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鼠李糖乳杆菌 vitaP1 对 P2X4 和 P2X7 的抑制：对宿醉症状的影响。

本研究旨在找出包括鼠李糖乳杆菌 vitaP1（KACC 92054P）在内的物质，以缓解宿醉引起的情绪焦虑和肝损伤。研究调查了宿醉引起的情绪焦虑与基因 P2X4、P2X7 和 SLC6A4 之间的关联。研究人员进行了体外和体内分析，以评估自由泛酸对酒精诱导的上调基因表达的影响。此外，还测定了血液中谷草转氨酶（AST）、谷丙转氨酶（ALT）、酒精和乙醛的浓度。Free-panica 由五种天然产品（Phyllanthus amarus、Phoenix dactylifera、Vitis vinifera、Zingiber officinale 和 Lactobacillus rhamnosus）组成，评估了它们对酒精诱导的情绪焦虑和肝损伤相关基因的调节作用。这些天然产品在自由盘尼卡中的组合成功地恢复了情绪焦虑，血液中的 AST、ALT、酒精和乙醛浓度也恢复到正常对照组的水平。这些研究结果支持将小茴香开发成一种保健功能食品或药物干预措施，以缓解宿醉症状并保护肝脏免受酒精伤害。

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来源期刊

AMB Express BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

7.20

自引率

2.70%

发文量

141

审稿时长

13 weeks

期刊介绍： AMB Express is a high quality journal that brings together research in the area of Applied and Industrial Microbiology with a particular interest in ''White Biotechnology'' and ''Red Biotechnology''. The emphasis is on processes employing microorganisms, eukaryotic cell cultures or enzymes for the biosynthesis, transformation and degradation of compounds. This includes fine and bulk chemicals, polymeric compounds and enzymes or other proteins. Downstream processes are also considered. Integrated processes combining biochemical and chemical processes are also published.