Cerebral vasculitis as a clinical manifestation of neurosarcoidosis: A scoping review

IF 9.2 1区 医学 Q1 IMMUNOLOGY Autoimmunity reviews Pub Date : 2024-03-16 DOI:10.1016/j.autrev.2024.103528
Yaroslav Winter , Sergiu Groppa , Timo Uphaus , Erik Ellwardt , Sven Fuest , Sven Meuth , Stefan Bittner , Eyad Hayani
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Abstract

The occurrence of cerebral vasculitis in individuals with neurosarcoidosis (NS) is considered to be rare. Although the number of relevant publications has increased in recent years, evidence is mostly limited to case reports. To obtain a better understanding of this rare and severe manifestation of disease, we carried out a scoping review on cerebral vasculitis in patients diagnosed with NS. The results of the review indicate that the diagnosis of cerebral vasculitis in patients with NS is made especially in patients with systemic sarcoidosis. However, recurrent strokes in patients with NS remains the main indicator of cerebral vasculitis. A tissue biopsy is considered the gold standard to confirm the diagnosis despite occasional false-negative results. Glucocorticoids and steroid-sparing agents are the most successful current treatments. Favorable outcomes were observed with strategies targeting TNFα and B cells. The goal of this review is to summarize the current literature and treatment options for cerebral vasculitis in patients with NS.

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作为神经肉芽肿病临床表现的脑血管炎:范围综述。
神经肉芽肿病(NS)患者发生脑血管炎被认为是罕见的。尽管近年来相关文献的数量有所增加,但证据大多仅限于病例报告。为了更好地了解这种罕见而严重的疾病表现,我们对确诊为神经肉芽肿病(NS)患者的脑血管炎进行了一次范围界定综述。综述结果表明,NS 患者中脑血管炎的诊断尤其适用于全身性肉样瘤病患者。然而,NS 患者反复中风仍是脑血管炎的主要指标。组织活检被认为是确诊的金标准,尽管有时会出现假阴性结果。糖皮质激素和节省类固醇的药物是目前最成功的治疗方法。针对 TNFα 和 B 细胞的治疗策略也取得了良好的疗效。本综述旨在总结目前的文献和治疗NS患者脑血管炎的方案。
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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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