Feliks Kogan, Daehyun Yoon, Matthew G Teeter, Abhijit J Chaudhari, Laurel Hales, Marco Barbieri, Garry E Gold, Yael Vainberg, Ananya Goyal, Lauren Watkins
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引用次数: 0
Abstract
Musculoskeletal (MSK) disorders are associated with large impacts on patient's pain and quality of life. Conventional morphological imaging of tissue structure is limited in its ability to detect pain generators, early MSK disease, and rapidly assess treatment efficacy. Positron emission tomography (PET), which offers unique capabilities to evaluate molecular and metabolic processes, can provide novel information about early pathophysiologic changes that occur before structural or even microstructural changes can be detected. This sensitivity not only makes it a powerful tool for detection and characterization of disease, but also a tool able to rapidly assess the efficacy of therapies. These benefits have garnered more attention to PET imaging of MSK disorders in recent years. In this narrative review, we discuss several applications of multimodal PET imaging in non-oncologic MSK diseases including arthritis, osteoporosis, and sources of pain and inflammation. We also describe technical considerations and recent advancements in technology and radiotracers as well as areas of emerging interest for future applications of multimodal PET imaging of MSK conditions. Overall, we present evidence that the incorporation of PET through multimodal imaging offers an exciting addition to the field of MSK radiology and will likely prove valuable in the transition to an era of precision medicine.
肌肉骨骼(MSK)疾病对患者的疼痛和生活质量有很大影响。传统的组织结构形态学成像在检测疼痛发生器、早期 MSK 疾病和快速评估治疗效果方面能力有限。正电子发射断层扫描(PET)具有评估分子和新陈代谢过程的独特功能,可提供有关早期病理生理变化的新信息,这些变化发生在结构甚至微观结构变化被检测到之前。这种灵敏度不仅使其成为检测和描述疾病的有力工具,还能快速评估治疗效果。近年来,这些优点使 MSK 疾病的 PET 成像受到更多关注。在这篇叙述性综述中,我们将讨论多模态 PET 成像在非肿瘤性 MSK 疾病中的几种应用,包括关节炎、骨质疏松症以及疼痛和炎症源。我们还介绍了技术考虑因素、技术和放射性核素的最新进展,以及 MSK 疾病多模式 PET 成像未来应用的新兴趣领域。总之,我们提出的证据表明,通过多模态成像结合 PET 为 MSK 放射学领域增添了令人兴奋的内容,在向精准医学时代过渡的过程中很可能被证明是有价值的。
期刊介绍:
Skeletal Radiology provides a forum for the dissemination of current knowledge and information dealing with disorders of the musculoskeletal system including the spine. While emphasizing the radiological aspects of the many varied skeletal abnormalities, the journal also adopts an interdisciplinary approach, reflecting the membership of the International Skeletal Society. Thus, the anatomical, pathological, physiological, clinical, metabolic and epidemiological aspects of the many entities affecting the skeleton receive appropriate consideration.
This is the Journal of the International Skeletal Society and the Official Journal of the Society of Skeletal Radiology and the Australasian Musculoskelelal Imaging Group.