An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY The Protein Journal Pub Date : 2024-03-16 DOI:10.1007/s10930-024-10190-4

Seyyedeh Mina Hejazian, Saeed Pirmoradi, Sepideh Zununi Vahed, Ripon Kumar Roy, Seyed Mahdi Hosseiniyan Khatibi

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Abstract

The hydrolysis of deacylated glycerophospholipids into sn-glycerol 3-phosphate and alcohol is facilitated by evolutionarily conserved proteins known as glycerophosphodiester phosphodiesterases (GDPDs). These proteins are crucial for the pathogenicity of bacteria and for bioremediation processes aimed at degrading organophosphorus esters that pose a hazard to both humans and the environment. Additionally, GDPDs are enzymes that respond to multiple nutrients and could potentially serve as candidate genes for addressing deficiencies in zinc, iron, potassium, and especially phosphate in important plants like rice. In mammals, glycerophosphodiesterases (GDEs) play a role in regulating osmolytes, facilitating the biosynthesis of anandamine, contributing to the development of skeletal muscle, promoting the differentiation of neurons and osteoblasts, and influencing pathological states. Due to their capacity to enhance a plant's ability to tolerate various nutrient deficiencies and their potential as pharmaceutical targets in humans, GDPDs have received increased attention in recent times. This review provides an overview of the functions of GDPD families as vital and resilient enzymes that regulate various pathways in bacteria, plants, and humans.

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甘油磷酸二酯磷酸二酯酶的最新进展；从细菌到人类。

称为甘油磷酸二酯磷酸二酯酶（GDPDs）的进化保守蛋白促进了脱乙酰甘油磷脂水解为 sn-甘油-3-磷酸酯和醇的过程。这些蛋白质对细菌的致病性以及旨在降解对人类和环境造成危害的有机磷酯的生物修复过程至关重要。此外，GDPDs 是对多种营养物质做出反应的酶，有可能成为解决水稻等重要植物中锌、铁、钾，特别是磷酸盐缺乏问题的候选基因。在哺乳动物中，甘油磷酸二酯酶（GDEs）在调节渗透压、促进安乃近的生物合成、促进骨骼肌的发育、促进神经元和成骨细胞的分化以及影响病理状态等方面发挥作用。由于 GDPDs 能够增强植物耐受各种营养素缺乏的能力，并有可能成为人类的药物靶标，因此近来受到越来越多的关注。本综述概述了 GDPD 家族的功能，它们是调控细菌、植物和人类各种途径的重要而顽强的酶。

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来源期刊

The Protein Journal 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

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审稿时长

12 months

期刊介绍： The Protein Journal (formerly the Journal of Protein Chemistry) publishes original research work on all aspects of proteins and peptides. These include studies concerned with covalent or three-dimensional structure determination (X-ray, NMR, cryoEM, EPR/ESR, optical methods, etc.), computational aspects of protein structure and function, protein folding and misfolding, assembly, genetics, evolution, proteomics, molecular biology, protein engineering, protein nanotechnology, protein purification and analysis and peptide synthesis, as well as the elucidation and interpretation of the molecular bases of biological activities of proteins and peptides. We accept original research papers, reviews, mini-reviews, hypotheses, opinion papers, and letters to the editor.