Reevaluating elevated HDL cholesterol levels in healthy older persons as a risk factor for various disease states.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2024-02-25 eCollection Date: 2024-01-01
Ren-Xin Ji, Zhou-Ying Duan
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Abstract

This article reviews the role of high-density lipoprotein cholesterol (HDL-C) in the elderly population, questioning the established view that advocates the ubiquitous health benefits of HDL cholesterol. High levels of HDL-C have been found to be associated with an increased risk of debilitating fractures, dementia, and cardiovascular disease, predominantly affecting older men, through the use of large population-based studies such as the ASPREE trial and the UK Biobank. Possible mechanisms are closely linked to cholesterol crystallization and altered HDL particle function. These findings call for a refinement of the understanding of high-density lipoprotein cholesterol (HDL-C), which implies adjustments to clinical guidelines and risk assessment strategies in older populations.

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重新评估健康老年人高密度脂蛋白胆固醇水平升高作为各种疾病风险因素的情况。
本文回顾了高密度脂蛋白胆固醇(HDL-C)在老年人群中的作用,对鼓吹高密度脂蛋白胆固醇无处不在的健康益处的既定观点提出了质疑。通过使用大型人群研究(如 ASPREE 试验和英国生物库)发现,高密度脂蛋白胆固醇水平与骨折、痴呆症和心血管疾病的风险增加有关,这些疾病主要影响老年男性。可能的机制与胆固醇结晶和高密度脂蛋白颗粒功能的改变密切相关。这些发现要求完善对高密度脂蛋白胆固醇(HDL-C)的认识,这意味着要调整老年人群的临床指南和风险评估策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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