Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals

The Journal of Physiological Sciences Pub Date : 2024-03-18 DOI:10.1186/s12576-024-00909-4

Keisho Katayama, Kana Shiozawa, Jordan B. Lee, Natsuki Seo, Haruna Kondo, Mitsuru Saito, Koji Ishida, Philip J. Millar, Ryoichi Banno, Shigehiko Ogoh

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Abstract

The purpose of this study was to clarify sex differences in the inhibition of sympathetic vasomotor outflow which is caused by the loading of cardiopulmonary baroreceptors. Ten young males and ten age-matched females participated. The participants underwent a passive leg raising (PLR) test wherein they were positioned supine (baseline, 0º), and their lower limbs were lifted passively at 10º, 20º, 30º, and 40º. Each angle lasted for 3 min. Muscle sympathetic nerve activity (MSNA) was recorded via microneurography of the left radial nerve. Baseline MSNA was lower in females compared to males. MSNA burst frequency was decreased during the PLR in both males (− 6.2 ± 0.4 bursts/min at 40º) and females (− 6.5 ± 0.4 bursts/min at 40º), but no significant difference was detected between the two groups (P = 0.61). These results suggest that sex has minimal influence on the inhibition of sympathetic vasomotor outflow during the loading of cardiopulmonary baroreceptors in young individuals.

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性别对年轻人被动抬腿时交感血管运动外流反应的影响

本研究的目的是阐明心肺气压感受器负荷导致的交感血管运动外流抑制的性别差异。十名年轻男性和十名年龄匹配的女性参加了这项研究。他们接受了被动抬腿（PLR）测试，测试中他们仰卧（基线，0º），下肢被动抬起 10º、20º、30º 和 40º。每个角度持续 3 分钟。肌肉交感神经活动（MSNA）通过左侧桡神经的微神经电图进行记录。与男性相比，女性的基线 MSNA 较低。在 PLR 期间，男性和女性的 MSNA 爆发频率均有所下降（40º 时为 - 6.2 ± 0.4 爆发/分钟），但两组之间未发现显著差异（P = 0.61）。这些结果表明，在年轻人的心肺气压感受器负荷期间，性别对交感血管运动外流的抑制影响很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journal of Physiological Sciences

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