Intra-bin correction and inter-bin compensation of respiratory motion in free-running five-dimensional whole-heart magnetic resonance imaging.

IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-03-16 DOI:10.1016/j.jocmr.2024.101037
Christopher W Roy, Bastien Milani, Jérôme Yerly, Salim Si-Mohamed, Ludovica Romanin, Aurélien Bustin, Estelle Tenisch, Tobias Rutz, Milan Prsa, Matthias Stuber
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Abstract

Background: Free-running cardiac and respiratory motion-resolved whole-heart five-dimensional (5D) cardiovascular magnetic resonance (CMR) can reduce scan planning and provide a means of evaluating respiratory-driven changes in clinical parameters of interest. However, respiratory-resolved imaging can be limited by user-defined parameters which create trade-offs between residual artifact and motion blur. In this work, we develop and validate strategies for both correction of intra-bin and compensation of inter-bin respiratory motion to improve the quality of 5D CMR.

Methods: Each component of the reconstruction framework was systematically validated and compared to the previously established 5D approach using simulated free-running data (N = 50) and a cohort of 32 patients with congenital heart disease. The impact of intra-bin respiratory motion correction was evaluated in terms of image sharpness while inter-bin respiratory motion compensation was evaluated in terms of reconstruction error, compression of respiratory motion, and image sharpness. The full reconstruction framework (intra-acquisition correction and inter-acquisition compensation of respiratory motion [IIMC] 5D) was evaluated in terms of image sharpness and scoring of image quality by expert reviewers.

Results: Intra-bin motion correction provides significantly (p < 0.001) sharper images for both simulated and patient data. Inter-bin motion compensation results in significant (p < 0.001) lower reconstruction error, lower motion compression, and higher sharpness in both simulated (10/11) and patient (9/11) data. The combined framework resulted in significantly (p < 0.001) sharper IIMC 5D reconstructions (End-expiration (End-Exp): 0.45 ± 0.09, End-inspiration (End-Ins): 0.46 ± 0.10) relative to the previously established 5D implementation (End-Exp: 0.43 ± 0.08, End-Ins: 0.39 ± 0.09). Similarly, image scoring by three expert reviewers was significantly (p < 0.001) higher using IIMC 5D (End-Exp: 3.39 ± 0.44, End-Ins: 3.32 ± 0.45) relative to 5D images (End-Exp: 3.02 ± 0.54, End-Ins: 2.45 ± 0.52).

Conclusion: The proposed IIMC reconstruction significantly improves the quality of 5D whole-heart MRI. This may be exploited for higher resolution or abbreviated scanning. Further investigation of the diagnostic impact of this framework and comparison to gold standards is needed to understand its full clinical utility, including exploration of respiratory-driven changes in physiological measurements of interest.

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在自由运行的 5D 全心磁共振成像中对呼吸运动进行区间校正和区间补偿。
背景:自由运行的心脏和呼吸运动分辨全心 5D MRI 可减少扫描计划,并提供一种评估呼吸驱动的临床相关参数变化的方法。然而,呼吸分辨成像可能会受到用户定义参数的限制,这些参数会在残留伪影和运动模糊之间产生权衡。在这项工作中,我们开发并验证了校正双腔内呼吸运动和补偿双腔间呼吸运动的策略,以提高 5D MRI 的质量:方法:使用模拟自由运行数据(N=50)和一组 32 名先天性心脏病患者,对重建框架的每个组件进行了系统验证,并与之前建立的 5D 方法进行了比较。从图像清晰度的角度评估了双腔内呼吸运动校正的影响,同时从重建误差、呼吸运动压缩和图像清晰度的角度评估了双腔间呼吸运动补偿的影响。整个重建框架(IIMC 5D)在图像清晰度方面进行了评估,并由专家评审员对图像质量进行评分:结果:在模拟数据和患者数据中,箱内运动校正可显著提高图像清晰度(p < 10-3)。在模拟数据(10/11)和患者数据(9/11)中,层间运动补偿可显著(p < 10-3)降低重建误差、减少运动压缩和提高清晰度。相对于之前建立的 5D 实施方案(End-Exp:0.43±0.08,End-Ins:0.39±0.09),组合框架使 IIMC 5D 重建图像清晰度明显提高(p < 10-3)(End-Exp:0.45±0.09,End-Ins:0.46±0.10)。同样,相对于 5D 图像(End-Exp:3.02±0.54,End-Ins:2.45±0.52),IIMC 5D 图像(End-Exp:3.39±0.44,End-Ins:3.32±0.45)的三位专家评审的评分显著提高(P < 10-3):结论:所提出的 IIMC 重建能显著提高 5D 全心磁共振成像的质量。结论:建议的 IIMC 重构能明显改善 5D 全心磁共振成像的质量,可用于更高分辨率或更简短的扫描。需要进一步研究该框架对诊断的影响,并与黄金标准进行比较,以了解其全部临床用途,包括探索呼吸驱动的相关生理测量变化。
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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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