Advancement in the development of gene/protein-based vaccines against African swine fever virus

IF 4.8 Q1 MICROBIOLOGY Current Research in Microbial Sciences Pub Date : 2024-01-01 DOI:10.1016/j.crmicr.2024.100232

Ning Wang , Pan Huang , Jun Zhang , Minqi Lin , Xiaoru Lai , Jianwen Chen , Chungen Pan

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Abstract

African swine fever (ASF) is a highly contagious acute hemorrhagic viral disease, with the mortality rate of up to 100 % in domestic pigs. In recent years, ASF outbreaks have caused huge economic losses in numerous countries and regions, especially in Asia. Therefore, there is a pressing need to develop safe and effective vaccines against infection of the causative pathogen, African swine fever virus (ASFV). ASFV contains a large genome composed of double-stranded DNA with a size of 170–194 kb, which encodes nearly 200 viral proteins. Understanding the function of these complex genes/proteins and their roles in the generation of protective immunity will help in the development of ASFV vaccines. In this article, the gene/protein-based vaccine candidate are summarized, and the structural proteins which have been previously reported to protect animals from the virus challenge were emphatically described.

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开发基于基因/蛋白质的非洲猪瘟病毒疫苗的进展情况

非洲猪瘟（ASF）是一种传染性极强的急性出血性病毒病，家猪死亡率高达 100%。近年来，非洲猪瘟疫情在许多国家和地区造成了巨大的经济损失，尤其是在亚洲。因此，迫切需要开发安全有效的疫苗来预防致病病原体非洲猪瘟病毒（ASFV）的感染。非洲猪瘟病毒包含一个由双链 DNA 组成的大型基因组，大小为 170-194 kb，其中编码近 200 种病毒蛋白。了解这些复杂基因/蛋白的功能及其在产生保护性免疫中的作用将有助于开发 ASFV 疫苗。本文对基于基因/蛋白的候选疫苗进行了总结，并重点描述了之前报道的能保护动物免受病毒挑战的结构蛋白。

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