Liposomic nano particles in the treatment of colorectal and ovarian cancer

Sheikh Rezzak Ali , Chinmoyee Deori , Gaurab Kr Gogoi , Naba Jyoti Borah , Prajnyan Prasad Kalita , Rubina Chowdhury , Simran Kaur , Bibhuti Bhusan Kakoti
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Abstract

Cancer is an expansionist disease, it invades through tissues, sets up colonies in hostile landscapes, seeking “sanctuary” in one organ and then immigrating to another. Ovarian and colorectal cancer has high mortality rates in India. Colorectal cancer typically begins in the gut lining and can spread through the colon wall and beneath the muscular layers, and is a significant source of morbidity. Ovarian cancer has the highest recurrence rate of all gynaecologic cancers and has high mortality because of late diagnosis brought on by vague symptoms. In this review article, we have discussed that apart from the conventional ways of treatment, how nanoparticles has the potential to improve the detection, diagnosis, and treatment of these cancers. Liposomal nanoparticles are lipid-based vesicles that can encapsulate drugs and deliver them to specific targets in the body, potentially improving the effectiveness and reducing the side effects of the treatment. This article also provides an insight on the fact that while liposomal nanoparticles show promising effect, there are challenges to be addressed, including optimizing drug release rates, and ensuring effective targeting.

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纳米脂质体颗粒在结直肠癌和卵巢癌治疗中的应用
癌症是一种扩张性疾病,它通过组织入侵,在充满敌意的环境中建立殖民地,在一个器官中寻找 "避难所",然后移民到另一个器官。在印度,卵巢癌和结肠直肠癌的死亡率很高。结肠直肠癌通常始于肠道内壁,可通过结肠壁和肌肉层下方扩散,是发病率的重要来源。在所有妇科癌症中,卵巢癌的复发率最高,而且由于症状模糊导致诊断较晚,因此死亡率很高。在这篇综述文章中,我们讨论了除了传统的治疗方法外,纳米粒子如何具有改善这些癌症的检测、诊断和治疗的潜力。脂质体纳米粒子是一种基于脂质的囊泡,可以封装药物并将其输送到体内的特定靶点,从而有可能提高疗效并减少副作用。本文还深入探讨了脂质体纳米粒子虽然显示出良好的效果,但仍有一些挑战需要解决,包括优化药物释放率和确保有效靶向。
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