{"title":"Base-mediated Transition-metal Free Regiospecific Substitution with Nitroarenes: Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes","authors":"","doi":"10.1134/s263482762360024x","DOIUrl":null,"url":null,"abstract":"<span> <h3>Abstract</h3> <p>Direct transition-metal free bond activation and bond formation reaction are central to the development of a sustainable and effective strategy for the synthesis of organic molecules. Facile, aerobic, regiospecific, base-mediated transition metal-free, and direct arylation reactions with inexpensive nitroarenes are need to explore. The use of strong base, promotes the vicarious nucleophilic substitution in nitroarenes. Moreover, functional group modification of synthesized nitroarenes compounds can open myriad applications in pharmaceutical and material industries. In this review, we summarize the recent progress achieved in the transition metal-free, base-mediated methodology has been employed for mono arylation, di-arylation, acylation, and aroylation reactions and we cover the research literature from 2013 to 2022. This review article presents the advantages, limitations, mechanistic rationalization, and future perspectives associated with synthetic methodologies.</p> </span>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews and Advances in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s263482762360024x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Direct transition-metal free bond activation and bond formation reaction are central to the development of a sustainable and effective strategy for the synthesis of organic molecules. Facile, aerobic, regiospecific, base-mediated transition metal-free, and direct arylation reactions with inexpensive nitroarenes are need to explore. The use of strong base, promotes the vicarious nucleophilic substitution in nitroarenes. Moreover, functional group modification of synthesized nitroarenes compounds can open myriad applications in pharmaceutical and material industries. In this review, we summarize the recent progress achieved in the transition metal-free, base-mediated methodology has been employed for mono arylation, di-arylation, acylation, and aroylation reactions and we cover the research literature from 2013 to 2022. This review article presents the advantages, limitations, mechanistic rationalization, and future perspectives associated with synthetic methodologies.
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