Preparation of Substituted gem-Dichlorocyclopropanes and 1,3-Dioxacycloalkanes and Their Biological Activity: A Review

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Abstract

Abstract―

This work generalizes methods for preparation of basic platform compounds, namely, hem-dichlorocyclopropanes and 1,3-dioxacycloalkanes with various substituents. On their basis, the synthesis of carbo- and heterocyclic compounds is carried out, which have herbicidal, cytotoxic, anticoagulant and antiaggregation properties and are of interest in terms of creating new pesticides for dicotyledonous and monocotyledonous plants, drugs that prevent blood clotting or inhibit the development of tumor cells.

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取代的二氯环丙烷和 1,3-二氧杂环烷的制备及其生物活性:综述
摘要-- 这项工作推广了基本平台化合物的制备方法,即带有各种取代基的半二氯环丙烷和 1,3-二氧杂环烷。这些化合物具有除草、细胞毒性、抗凝血和抗聚集等特性,对制造双子叶和单子叶植物的新农药、防止血液凝固或抑制肿瘤细胞发展的药物具有重要意义。
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