{"title":"Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata","authors":"Shi-Hui Qin, Zhi-Lan Li, Liu Yang, Jiang-Miao Hu","doi":"10.1007/s13659-024-00430-6","DOIUrl":null,"url":null,"abstract":"<div><p>Based on the research progress and traditional usage with whole herbal of the TCM \"Tianma\", chemical studies herein on the flower branch of <i>Gastrodia</i> <i>elata</i> were carried out in-depth and got 13 compounds including the gastrodinols (<b>1–4</b>), the flavonoid morins (<b>5–8, 11–12</b>), together with the specialist mulberrofurans (<b>9</b>, <b>13</b>) and gastrodiamide (<b>10</b>) for the first time from the species. The antibacterial and cholinesterase inhibitory activities were then evaluated and the results showed that compounds<b> 5</b>, <b>11</b>, <b>12</b>, <b>13</b> have good activity against anti-methicillin-resistant <i>Staphylococcus</i> <i>aureus</i>, and compounds <b>9</b>, <b>13</b> had good acetylcholinesterase inhibitory activity. All these results provide new chemical composition for better understanding the traditional application of \"Tianma\" and for exploring new pharmacological ingredients.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00430-6.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-024-00430-6","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
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Abstract
Based on the research progress and traditional usage with whole herbal of the TCM "Tianma", chemical studies herein on the flower branch of Gastrodiaelata were carried out in-depth and got 13 compounds including the gastrodinols (1–4), the flavonoid morins (5–8, 11–12), together with the specialist mulberrofurans (9, 13) and gastrodiamide (10) for the first time from the species. The antibacterial and cholinesterase inhibitory activities were then evaluated and the results showed that compounds 5, 11, 12, 13 have good activity against anti-methicillin-resistant Staphylococcusaureus, and compounds 9, 13 had good acetylcholinesterase inhibitory activity. All these results provide new chemical composition for better understanding the traditional application of "Tianma" and for exploring new pharmacological ingredients.
期刊介绍：
Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects:
Natural products: isolation and structure elucidation
Natural products: synthesis
Biological evaluation of biologically active natural products
Bioorganic and medicinal chemistry
Biosynthesis and microbiological transformation
Fermentation and plant tissue cultures
Bioprospecting of natural products from natural resources
All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.
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