Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-03-20 DOI:10.1007/s13659-024-00430-6

Shi-Hui Qin, Zhi-Lan Li, Liu Yang, Jiang-Miao Hu

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Abstract

Based on the research progress and traditional usage with whole herbal of the TCM "Tianma", chemical studies herein on the flower branch of Gastrodia elata were carried out in-depth and got 13 compounds including the gastrodinols (1–4), the flavonoid morins (5–8, 11–12), together with the specialist mulberrofurans (9, 13) and gastrodiamide (10) for the first time from the species. The antibacterial and cholinesterase inhibitory activities were then evaluated and the results showed that compounds 5, 11, 12, 13 have good activity against anti-methicillin-resistant Staphylococcus aureus, and compounds 9, 13 had good acetylcholinesterase inhibitory activity. All these results provide new chemical composition for better understanding the traditional application of "Tianma" and for exploring new pharmacological ingredients.

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从天麻花枝中提取的天麻素衍生物和炔化黄酮类化合物

根据天麻的研究进展和天麻全草的传统用法，本文对天麻花枝进行了深入的化学研究，首次从天麻中获得了13个化合物，包括天麻素（1-4）、黄酮类吗啉（5-8，11-12）以及专科木鳖子呋喃（9，13）和天麻二酰胺（10）。结果表明，化合物 5、11、12 和 13 对抗耐甲氧西林金黄色葡萄球菌具有良好的活性，化合物 9 和 13 具有良好的乙酰胆碱酯酶抑制活性。所有这些结果为更好地了解 "天麻 "的传统应用和探索新的药理成分提供了新的化学成分。图文摘要

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