Current alternative therapies for treating drug-resistant Neisseria gonorrhoeae causing ophthalmia neonatorum.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-01 Epub Date: 2024-03-21 DOI:10.2217/fmb-2023-0251
Praveen Belagal
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Abstract

Ophthalmia neonatorum is a microbial contraction, damaging eyesight, occurring largely among neonates. Infants are particularly vulnerable to bacterial infections acquired during birth from infected mothers, especially from Neisseria gonorrhoeae and Chlamydia trachomatis. Over the decades, N. gonorrhoeae is alarmingly developing a resistance to most antibiotics currently prescribed. To counter this challenge, it is imperative to find potent and cost-effective therapeutic agents for prophylaxis and treatment, to which the N. gonorrhoeae cannot easily develop resistance. This review showcases alternate therapies such as antimicrobial-fatty acids, -peptides, -nano-formulations etc., currently evident against N. gonorrhoeae-mediated ophthalmia neonatorum, which remains a major cause of ocular morbidity, blindness and even death among neonates in developing countries.

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目前治疗引起新生儿眼炎的耐药淋病奈瑟菌的替代疗法。
新生儿眼炎是一种损害视力的微生物感染,主要发生在新生儿中。婴儿在出生时特别容易受到受感染母亲的细菌感染,尤其是淋病奈瑟菌和沙眼衣原体。几十年来,淋病奈瑟菌对目前处方中的大多数抗生素产生了惊人的抗药性。为了应对这一挑战,当务之急是找到淋球菌不易产生耐药性的强效且具有成本效益的预防和治疗药物。淋病引发的新生儿眼炎仍是发展中国家新生儿眼部发病、失明甚至死亡的主要原因,本综述展示了目前针对淋病引发的新生儿眼炎的其他疗法,如抗菌脂肪酸、肽、纳米制剂等。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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