Association Between Hashimoto's Thyroiditis and Rheumatoid Arthritis: A Bidirectional Mendelian Randomization Study.

IF 1.1 4区 生物学 Q4 GENETICS & HEREDITY Genetic testing and molecular biomarkers Pub Date : 2024-05-01 Epub Date: 2024-03-20 DOI:10.1089/gtmb.2023.0594
Jialin Liang, Zhaopu Jing, Yuanqing Cai, Leifeng Lv, Guangyang Zhang, Kai Nan, Xiaoqian Dang
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Abstract

Background: We aim to investigate the possible causal association between Hashimoto's thyroiditis (HT) and rheumatoid arthritis (RA) using Mendelian randomization (MR) methods. Methods: A bidirectional MR analysis was conducted to evaluate the causal association between HT and RA. We obtained summary statistics data from two extensive genome-wide association studies (GWAS) comprising 15,654 cases of HT and 14,361 cases of RA. The primary effect estimate utilized in this study was the inverse-variance weighted (IVW) method. To ensure the reliability and stability of the results, we employed several additional methods for testing, including MR-Egger, weighted median, simple mode, weighted mode, and MR-PRESSO. Results: Our study revealed compelling evidence of bidirectional causality between HT and RA. When HT was considered as an exposure factor and RA was considered as an outcome factor, this study revealed a positive correlation between HT and RA (IVW: odds ratio [OR] = 2.4546, 95% confidence interval [CI], 1.1473-5.2512; p = 0.0207). Conversely, when we examined RA as the exposure factor and HT as the outcome factor, we still found a positive correlation between them (IVW: OR = 1.2113, 95% CI, 1.1248-1.3044; p = 3.9478 × 10-7). Conclusions: According to our research findings, there exists a bidirectional positive causal relationship between HT and RA among European populations. This implies that individuals with HT have an elevated risk of developing RA, and conversely, individuals with RA have an increased risk of developing HT.

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桥本氏甲状腺炎与类风湿关节炎之间的关系:双向孟德尔随机研究
背景:我们旨在利用孟德尔随机化(MR)方法研究桥本氏甲状腺炎(HT)与类风湿性关节炎(RA)之间可能存在的因果关系。研究方法为评估桥本氏甲状腺炎与类风湿关节炎之间的因果关系,我们进行了双向 MR 分析。我们从两项广泛的全基因组关联研究(GWAS)中获得了汇总统计数据,其中包括 15654 例 HT 和 14361 例 RA。本研究采用的主要效应估计方法是逆方差加权法(IVW)。为确保结果的可靠性和稳定性,我们还采用了其他几种方法进行测试,包括 MR-Egger、加权中位数、简单模式、加权模式和 MR-PRESSO。结果我们的研究揭示了 HT 与 RA 之间双向因果关系的有力证据。当 HT 被视为暴露因素,而 RA 被视为结果因素时,本研究显示 HT 与 RA 之间存在正相关性(IVW:几率比 [OR] = 2.4546,95% 置信区间 [CI],1.1473-5.2512;P = 0.0207)。相反,当我们将 RA 作为暴露因素,将 HT 作为结果因素时,我们仍然发现它们之间存在正相关性(IVW:OR = 1.2113,95% 置信区间 [CI],1.1248-1.3044;P = 3.9478 × 10-7)。结论根据我们的研究结果,在欧洲人群中,高血压与 RA 之间存在双向的正向因果关系。这意味着患有 HT 的人患 RA 的风险会升高,反之,患有 RA 的人患 HT 的风险也会升高。
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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
63
审稿时长
1 months
期刊介绍: Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results. Genetic Testing and Molecular Biomarkers coverage includes: -Diagnosis across the life span- Risk assessment- Carrier detection in individuals, couples, and populations- Novel methods and new instrumentation for genetic testing- Results of molecular, biochemical, and cytogenetic testing- Genetic counseling
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