The influence of polyimide MP-1™ wear particles on a rodent closed fracture healing model.

IF 3.1 4区 医学 Q2 BIOPHYSICS Journal of Applied Biomaterials & Functional Materials Pub Date : 2024-01-01 DOI:10.1177/22808000241240296
Rema A Oliver, Tian Wang, Chris Christou, Alisa Buchman, Simha Sibony, William R Walsh
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Abstract

Joint replacements provide pain free movement for the injured or our aging population. Current prothesis mainly consist of hard metal on metal, or ceramic femoral head on ultra-high-molecular weight polyethylene (UHMWPE). In this study, a rodent fracture model was used to test the influence of wear debris from a high-performance polymer (polyimide MP-1™). Saline, MP-1™ Low Dose in Saline (1%), or MP-1 High Dose (2%) in Saline was injected directly into a standard closed unilateral femoral fracture in 12-week old Sprague Dawley rats (n = 25) for 1, 3 and 6 weeks. Endpoints included radiography, micro-computed tomography, mechanical testing and paraffin histology. No adverse effects from the wear particles were observed from the current study based on radiology, mechanical or histological data. Although the particles were present, histological analysis revealed a progression in healing between the Polyimide treated groups and the non-treated saline control groups over the duration of 1, 3, and 6 weeks, with no inhibition from the particles. The MP-1™ wear debris generated are larger than 1 µm thus are not able to be engulfed by macrophages and cause osteolysis. This family of polymers (polyimides) may be an ideal material to consider for articulating joints and other implants in the human body.

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聚酰亚胺 MP-1™ 磨损颗粒对啮齿动物闭合性骨折愈合模型的影响。
关节置换为伤员或老龄人口提供无痛运动。目前的假体主要由硬金属与金属或陶瓷股骨头与超高分子量聚乙烯(UHMWPE)组成。本研究使用啮齿动物骨折模型来测试高性能聚合物(聚酰亚胺 MP-1™)磨损碎片的影响。将生理盐水、生理盐水中的 MP-1™ 低剂量(1%)或生理盐水中的 MP-1 高剂量(2%)直接注射到 12 周大的 Sprague Dawley 大鼠(n = 25)的标准闭合性单侧股骨骨折处,注射时间分别为 1、3 和 6 周。终点包括射线照相术、微型计算机断层扫描、机械测试和石蜡组织学。根据放射学、机械学或组织学数据,目前的研究没有观察到磨损颗粒的不良影响。虽然存在微粒,但组织学分析表明,在 1、3 和 6 周的时间内,聚酰亚胺处理组和未经处理的生理盐水对照组的愈合情况都有所改善,微粒对愈合没有抑制作用。产生的 MP-1™ 磨损碎片大于 1 微米,因此无法被巨噬细胞吞噬,也就不会导致骨溶解。这一系列聚合物(聚酰亚胺)可能是用于人体关节和其他植入物的理想材料。
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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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