Regulation of m6Am RNA modification and its implications in human diseases.

IF 5.3 2区 生物学 Q2 CELL BIOLOGY Journal of Molecular Cell Biology Pub Date : 2024-08-26 DOI:10.1093/jmcb/mjae012
Hao Jin, Zhouyuanjing Shi, Tianhua Zhou, Shanshan Xie
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Abstract

N 6,2'-O-dimethyladenosine (m6Am) is a prevalent modification frequently found at the 5' cap-adjacent adenosine of messenger RNAs (mRNAs) and small nuclear RNAs (snRNAs) and the internal adenosine of snRNAs. This dynamic and reversible modification is under the regulation of methyltransferases phosphorylated CTD interacting factor 1 and methyltransferase-like protein 4, along with the demethylase fat mass and obesity-associated protein. m6Am RNA modification plays a crucial role in the regulation of pre-mRNA splicing, mRNA stability, and translation, thereby influencing gene expression. In recent years, there has been growing interest in exploring the functions of m6Am and its relevance to human diseases. In this review, we provide a comprehensive overview of the current knowledge concerning m6Am, with a focus on m6Am-modifying enzymes, sequencing approaches for its detection, and its impacts on pre-mRNA splicing, mRNA stability, and translation regulation. Furthermore, we highlight the roles of m6Am in the context of obesity, viral infections, and cancers, unravelling its underlying regulatory mechanisms.

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m6Am RNA修饰的调控及其对人类疾病的影响。
N 6,2'-O-二甲基腺苷(m6Am)是一种常见的修饰,经常出现在 mRNA 和 snRNA 的 5'帽旁腺苷以及 snRNA 的内部腺苷上。m6Am RNA 修饰在调控前 mRNA 剪接、mRNA 稳定性和翻译,从而影响基因表达方面起着至关重要的作用。近年来,人们对探索 m6Am 的功能及其与人类疾病的相关性越来越感兴趣。在这篇综述中,我们全面概述了目前有关 m6Am 的知识,重点介绍了 m6Am 修饰酶、其检测测序方法及其对前 mRNA 剪接、mRNA 稳定性和翻译调控的影响。此外,我们还强调了 m6Am 在肥胖、病毒感染和癌症中的作用,并揭示了其潜在的调控机制。
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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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