A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation

IF 21.2 1区 医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2024-03-22 DOI:10.1038/s41593-024-01605-7
Ke Bo, Thomas E. Kraynak, Mijin Kwon, Michael Sun, Peter J. Gianaros, Tor D. Wager
{"title":"A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation","authors":"Ke Bo, Thomas E. Kraynak, Mijin Kwon, Michael Sun, Peter J. Gianaros, Tor D. Wager","doi":"10.1038/s41593-024-01605-7","DOIUrl":null,"url":null,"abstract":"Cognitive reappraisal is fundamental to cognitive therapies and everyday emotion regulation. Analyses using Bayes factors and an axiomatic systems identification approach identified four reappraisal-related components encompassing distributed neural activity patterns across two independent functional magnetic resonance imaging (fMRI) studies (n = 182 and n = 176): (1) an anterior prefrontal system selectively involved in cognitive reappraisal; (2) a fronto-parietal-insular system engaged by both reappraisal and emotion generation, demonstrating a general role in appraisal; (3) a largely subcortical system activated during negative emotion generation but unaffected by reappraisal, including amygdala, hypothalamus and periaqueductal gray; and (4) a posterior cortical system of negative emotion-related regions downregulated by reappraisal. These systems covaried with individual differences in reappraisal success and were differentially related to neurotransmitter binding maps, implicating cannabinoid and serotonin systems in reappraisal. These findings challenge ‘limbic’-centric models of reappraisal and provide new systems-level targets for assessing and enhancing emotion regulation. Two fMRI studies (n = 358) show that cognitive regulation of negative emotion alters cortical activity but not amygdala or other subcortical areas. Regulation-related activity overlaps with emotion generation systems but also involves distinct areas.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"27 5","pages":"975-987"},"PeriodicalIF":21.2000,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41593-024-01605-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Cognitive reappraisal is fundamental to cognitive therapies and everyday emotion regulation. Analyses using Bayes factors and an axiomatic systems identification approach identified four reappraisal-related components encompassing distributed neural activity patterns across two independent functional magnetic resonance imaging (fMRI) studies (n = 182 and n = 176): (1) an anterior prefrontal system selectively involved in cognitive reappraisal; (2) a fronto-parietal-insular system engaged by both reappraisal and emotion generation, demonstrating a general role in appraisal; (3) a largely subcortical system activated during negative emotion generation but unaffected by reappraisal, including amygdala, hypothalamus and periaqueductal gray; and (4) a posterior cortical system of negative emotion-related regions downregulated by reappraisal. These systems covaried with individual differences in reappraisal success and were differentially related to neurotransmitter binding maps, implicating cannabinoid and serotonin systems in reappraisal. These findings challenge ‘limbic’-centric models of reappraisal and provide new systems-level targets for assessing and enhancing emotion regulation. Two fMRI studies (n = 358) show that cognitive regulation of negative emotion alters cortical activity but not amygdala or other subcortical areas. Regulation-related activity overlaps with emotion generation systems but also involves distinct areas.

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
利用贝叶斯因子的系统识别方法解构情绪调节的大脑基础
认知再评价是认知疗法和日常情绪调节的基础。利用贝叶斯因子和公理系统识别方法进行的分析发现,在两项独立的功能磁共振成像(fMRI)研究(n = 182 和 n = 176)中,与再评价相关的四个组成部分包含分布式神经活动模式:(1) 选择性参与认知再评价的前额叶系统;(2) 同时参与再评价和情绪生成的额叶-顶叶-脑岛系统,显示其在评价中的一般作用;(3) 在负面情绪产生过程中被激活但不受再评价影响的皮层下系统,包括杏仁核、下丘脑和丘脑周围灰质;以及 (4) 受再评价影响而下调的负面情绪相关区域的皮层后部系统。这些系统与再评价成功与否的个体差异有关,并与神经递质结合图谱有不同关系,表明大麻素和血清素系统与再评价有关。这些发现对以 "边缘 "为中心的再评价模型提出了挑战,并为评估和加强情绪调节提供了新的系统级目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
期刊最新文献
A distinct hypothalamus–habenula circuit governs risk preference Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus NOMPC ion channel hinge forms a gating spring that initiates mechanosensation Context-dependent decision-making in the primate hippocampal–prefrontal circuit
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1