Hungatella hathewayi bacteremia due to acute appendicitis: A case report and a narrative review

IF 2.5 3区 生物学 Q3 MICROBIOLOGY Anaerobe Pub Date : 2024-03-21 DOI:10.1016/j.anaerobe.2024.102838
Elie Bou Sanayeh , Mark Tawfik , Marina Makram , Georges Khattar , Faris Qaqish , Sudeep Acharya , Janet Farag , Michel Chalhoub , Allison Glaser
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Abstract

Hungatella species, including Hungatella hathewayi and Hungatella effluvii, previously identified as part of the Clostridium genus, are anaerobic bacteria primarily residing in the gut microbiome, with infrequent implications in human infections. This article presents the case of an 87-year-old Asian male admitted for a hyperosmolar hyperglycemic state with septic shock secondary to Hungatella hathewayi bacteremia originating from acute appendicitis. Remarkably, the bacterium was detected in the blood 48 hours before the emergence of clinical and radiographic evidence of acute appendicitis. Additionally, we conducted a literature review to identify all documented human infections caused by Hungatella species. Timely microbial identification in such cases is essential for implementing targeted antibiotic therapy and optimizing clinical outcomes.

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由急性阑尾炎引起的 Hungatella hathewayi 菌血症:病例报告和综述。
Hungatella 物种,包括 Hungatella hathewayi 和 Hungatella effluvii,以前被确定为梭状芽孢杆菌属的一部分,是一种厌氧菌,主要栖息于肠道微生物群中,很少涉及人类感染。本文介绍的病例是一名 87 岁的亚洲男性,因急性阑尾炎引起的 Hungatella hathewayi 菌血症导致高渗性高血糖和脓毒性休克而入院。值得注意的是,在出现急性阑尾炎的临床和影像学证据前 48 小时,我们就在血液中检测到了该细菌。此外,我们还查阅了文献,以确定所有由 Hungatella 菌引起的人类感染记录。在此类病例中及时识别微生物对于实施有针对性的抗生素治疗和优化临床结果至关重要。
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来源期刊
Anaerobe
Anaerobe 生物-微生物学
CiteScore
5.20
自引率
8.70%
发文量
137
审稿时长
76 days
期刊介绍: Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.
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