Spatial omics techniques and data analysis for cancer immunotherapy applications

IF 7.1 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS Current opinion in biotechnology Pub Date : 2024-03-22 DOI:10.1016/j.copbio.2024.103111

Yue Zhang , Ren Yuan Lee , Chin Wee Tan , Xue Guo , Willa W-Y Yim , Jeffrey CT Lim , Felicia YT Wee , WU Yang , Malvika Kharbanda , Jia-Ying J Lee , Nye Thane Ngo , Wei Qiang Leow , Lit-Hsin Loo , Tony KH Lim , Radoslaw M Sobota , Mai Chan Lau , Melissa J Davis , Joe Yeong

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Abstract

In-depth profiling of cancer cells/tissues is expanding our understanding of the genomic, epigenomic, transcriptomic, and proteomic landscape of cancer. However, the complexity of the cancer microenvironment, particularly its immune regulation, has made it difficult to exploit the potential of cancer immunotherapy. High-throughput spatial omics technologies and analysis pipelines have emerged as powerful tools for tackling this challenge. As a result, a potential revolution in cancer diagnosis, prognosis, and treatment is on the horizon. In this review, we discuss the technological advances in spatial profiling of cancer around and beyond the central dogma to harness the full benefits of immunotherapy. We also discuss the promise and challenges of spatial data analysis and interpretation and provide an outlook for the future.

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应用于癌症免疫疗法的空间 omics 技术和数据分析。

对癌细胞/组织的深入分析正在扩大我们对癌症基因组、表观基因组、转录组和蛋白质组情况的了解。然而，癌症微环境的复杂性，尤其是其免疫调节，使得癌症免疫疗法的潜力难以发挥。高通量空间 omics 技术和分析管道已成为应对这一挑战的有力工具。因此，一场潜在的癌症诊断、预后和治疗革命即将到来。在这篇综述中，我们将围绕和超越利用免疫疗法全部益处的中心教条，讨论癌症空间剖析的技术进展。我们还讨论了空间数据分析和解读的前景与挑战，并对未来进行了展望。

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.