Glycative stress as a cause of macular degeneration

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2024-03-21 DOI:10.1016/j.preteyeres.2024.101260
Eloy Bejarano , Alicia Domenech-Bendaña , Norma Avila-Portillo , Sheldon Rowan , Sachini Edirisinghe , Allen Taylor
{"title":"Glycative stress as a cause of macular degeneration","authors":"Eloy Bejarano ,&nbsp;Alicia Domenech-Bendaña ,&nbsp;Norma Avila-Portillo ,&nbsp;Sheldon Rowan ,&nbsp;Sachini Edirisinghe ,&nbsp;Allen Taylor","doi":"10.1016/j.preteyeres.2024.101260","DOIUrl":null,"url":null,"abstract":"<div><p>People are living longer and rates of age-related diseases such as age-related macular degeneration (AMD) are accelerating, placing enormous burdens on patients and health care systems. The quality of carbohydrate foods consumed by an individual impacts health<em>.</em> The glycemic index (GI) is a kinetic measure of the rate at which glucose arrives in the blood stream after consuming various carbohydrates. Consuming diets that favor slowly digested carbohydrates releases sugar into the bloodstream gradually after consuming a meal (low glycemic index). This is associated with reduced risk for major age-related diseases including AMD, cardiovascular disease, and diabetes<em>.</em> In comparison, consuming the same amounts of different carbohydrates in higher GI diets, releases glucose into the blood rapidly, causing glycative stress as well as accumulation of advanced glycation end products (AGEs). Such AGEs are cytotoxic by virtue of their forming abnormal proteins and protein aggregates, as well as inhibiting proteolytic and other protective pathways that might otherwise selectively recognize and remove toxic species. Using <em>in vitro</em> and animal models of glycative stress, we observed that consuming higher GI diets perturbs metabolism and the microbiome, resulting in a shift to more lipid-rich metabolomic profiles. Interactions between aging, diet, eye phenotypes and physiology were observed. A large body of laboratory animal and human clinical epidemiologic data indicates that consuming lower GI diets, or lower glycemia diets, is protective against features of early AMD (AMDf) in mice and AMD prevalence or AMD progression in humans. Drugs may be optimized to diminish the ravages of higher glycemic diets. Human trials are indicated to determine if AMD progression can be retarded using lower GI diets. Here we summarized the current knowledge regarding the pathological role of glycative stress in retinal dysfunction and how dietary strategies might diminish retinal disease.</p></div>","PeriodicalId":21159,"journal":{"name":"Progress in Retinal and Eye Research","volume":null,"pages":null},"PeriodicalIF":18.6000,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Retinal and Eye Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1350946224000259","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

People are living longer and rates of age-related diseases such as age-related macular degeneration (AMD) are accelerating, placing enormous burdens on patients and health care systems. The quality of carbohydrate foods consumed by an individual impacts health. The glycemic index (GI) is a kinetic measure of the rate at which glucose arrives in the blood stream after consuming various carbohydrates. Consuming diets that favor slowly digested carbohydrates releases sugar into the bloodstream gradually after consuming a meal (low glycemic index). This is associated with reduced risk for major age-related diseases including AMD, cardiovascular disease, and diabetes. In comparison, consuming the same amounts of different carbohydrates in higher GI diets, releases glucose into the blood rapidly, causing glycative stress as well as accumulation of advanced glycation end products (AGEs). Such AGEs are cytotoxic by virtue of their forming abnormal proteins and protein aggregates, as well as inhibiting proteolytic and other protective pathways that might otherwise selectively recognize and remove toxic species. Using in vitro and animal models of glycative stress, we observed that consuming higher GI diets perturbs metabolism and the microbiome, resulting in a shift to more lipid-rich metabolomic profiles. Interactions between aging, diet, eye phenotypes and physiology were observed. A large body of laboratory animal and human clinical epidemiologic data indicates that consuming lower GI diets, or lower glycemia diets, is protective against features of early AMD (AMDf) in mice and AMD prevalence or AMD progression in humans. Drugs may be optimized to diminish the ravages of higher glycemic diets. Human trials are indicated to determine if AMD progression can be retarded using lower GI diets. Here we summarized the current knowledge regarding the pathological role of glycative stress in retinal dysfunction and how dietary strategies might diminish retinal disease.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
糖应激是黄斑变性的原因之一。
人们的寿命越来越长,与年龄相关的疾病(如老年黄斑变性)的发病率也在加速上升,这给患者和医疗系统带来了巨大的负担。个人摄入碳水化合物食物的质量会影响健康。血糖生成指数(GI)是衡量摄入各种碳水化合物后葡萄糖进入血流速度的动力学指标。偏向于缓慢消化碳水化合物的饮食会在进餐后逐渐将糖分释放到血液中(低血糖生成指数)。这与降低罹患老年痴呆症、心血管疾病和糖尿病等主要老年疾病的风险有关。相比之下,在高血糖生成指数饮食中摄入相同数量的不同碳水化合物,葡萄糖会迅速释放到血液中,造成糖应激以及高级糖化终产物(AGEs)的积累。 这些 AGEs 具有细胞毒性,因为它们会形成异常蛋白质和蛋白质聚集体,并抑制蛋白水解和其他保护途径,而这些途径可能会选择性地识别和清除有毒物质。利用糖应激的体外模型和动物模型,我们观察到摄入较高 GI 的饮食会扰乱新陈代谢和微生物组,导致代谢组谱向更富含脂质的方向转变。我们还观察到了衰老、饮食、眼睛表型和生理学之间的相互作用。大量实验室动物和人类临床流行病学数据表明,食用低 GI 或低血糖饮食对小鼠早期 AMD(AMDf)特征和人类 AMD 发病率或 AMD 进展具有保护作用。可以对药物进行优化,以减少高血糖饮食的摧残。目前正在进行人体试验,以确定使用低 GI 饮食能否延缓 AMD 的进展。在此,我们总结了有关糖应激在视网膜功能障碍中的病理作用以及饮食策略如何减轻视网膜疾病的现有知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
期刊最新文献
Dual inheritance patterns: a spectrum of non-syndromic inherited retinal disease phenotypes with varying molecular mechanisms. Eye on the horizon: The metabolic landscape of the RPE in aging and disease Standard automated perimetry for glaucoma and diseases of the retina and visual pathways: current and future perspectives. Pathobiology of the crystalline lens in Stickler syndrome AI in the clinical management of GA: A novel therapeutic universe requires novel tools
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1