Biosensor Chip for Point-of-Care Diagnostics: Carbon Nanotube Sensing Platform for Bacterial Detection and Identification

Abstract

Emerging technologies, such as carbon nanotubes (CNTs), show exciting benefits for next-generation electronic systems and have recently been incorporated within commercial fabrication facilities and foundries. Here we demonstrate a real-world application of carbon nanotube field-effect transistors (CNFETs) leveraging these foundry capabilities: performing disease diagnostics by detecting and identifying infectious pathogens in model biological samples. This Biosensor chip leverages the benefits of 200 mm wafer-scale and VLSI-compatible foundry fabrication of CNFETs, which can be seamlessly integrated with the mature sensing modality of antibody-based targeted antigen binding, to realize a robust and manufacturable biosensor technology. As a demonstration, we realize Biosensor chips that are capable of detecting and identifying three different infectious pathogens simultaneously through multiplexing across hundreds of functionalized CNFET-antibody biosensors within each chip.