Clinical perspective on topical vaccination strategies

IF 15.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Advanced drug delivery reviews Pub Date : 2024-03-24 DOI:10.1016/j.addr.2024.115292
Petya G. Popova , Sunny P. Chen , Suiyang Liao , Manish Sadarangani , Anna K. Blakney
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Abstract

Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventional intramuscular administration because of its potential to be needle-free and induce a superior immune response against pathogens. In this review, we describe recent progress in developing topical vaccines, highlight progress in the development of delivery technologies for topical vaccines, discuss potential factors that might impact the topical vaccine efficacy, and provide an overview of the current clinical landscape of topical vaccines.

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从临床角度看局部疫苗接种策略。
疫苗接种是现代医学中防治疾病(尤其是传染病)最成功的措施之一,每年挽救数百万人的生命。疫苗的设计和开发仍然至关重要,涉及许多方面,包括平台、抗原、佐剂和给药途径的选择。局部疫苗接种是指将疫苗接种到人体皮肤三层中的任何一层,近年来,局部疫苗接种作为一种替代传统肌肉注射的疫苗接种方法引起了人们的兴趣,因为它具有无针接种和诱导针对病原体的卓越免疫反应的潜力。在这篇综述中,我们介绍了开发局部疫苗的最新进展,重点介绍了局部疫苗递送技术的开发进展,讨论了可能影响局部疫苗疗效的潜在因素,并概述了局部疫苗目前的临床状况。
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来源期刊
CiteScore
28.10
自引率
5.00%
发文量
294
审稿时长
15.1 weeks
期刊介绍: The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
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